摘要:
Disclosed are non-peptide compounds having activity as selective antagonists of bradykinin (BK) B2 receptor. The compounds are chemically characterized by the presence of an amino acid alpha substituted with a cyclic group and by a tetraalkylammonium group. Also disclosed are pharmaceutical compositions containing the compound, and methods of using the compounds to treat patients having conditions, disorders or diseases involving activation of bradykinin B2 receptor.
摘要:
Non-peptide compounds of formula (I) having activity as specific antagonists of bradykinin (BK) B2 receptor. The compounds are chemically characterized by the presence of an alpha, alpha-disubstituted amino acid at least one amino group, free or salified, or the corresponding ammonium quaternary salt. These BK receptor antagonists are a novel class of medicaments which can be used in all the disorders in which said receptors are involved
摘要:
The present invention describes compounds with formula (I) having linear structure basic properties useful as NK-2 antagonists; pharmaceutical compositions containing said compounds are also described and processes for their preparation.
摘要:
An operating table for ophthalmic surgery consisting of a base, held at an adequate height from the floor by supporting members, and on which a stretcher is placed which is movable in the longitudinal sense and adjustable in height, one end of which is connected to an adjustable assembly comprising a first device for positioning the patient's head, with the body being on said stretcher, in the position most convenient for carrying out the surgical operation and a second device supporting a mask element provided with an opening in which the eye to be operated on is adapted and on the edge of which the orbital edge of said eye is sealed. A transparent rigid airtight cover is provided which may be adapted on said base plane in such a way as to create an airtight environment apt to be appropriately depressurized through conventional vacuum means, said airtight environment completely surrounding the body of the patient with the exception of the eye to be operated on, which through said opening in said mask element appears exposed to the pressure of the outside ambient.
摘要:
A turbine blade, preferably used in the low pressure stages of a steam turbine, is formed from a basic titanium alloy. Near the blade tip, it has a region, including the blade leading edge with a surface of a material which is more resistant to erosion than the basic titanium alloy.This turbine blade should be simple to manufacture and should have a long life even under difficult operating conditions.This is achieved in that the region including the blade leading edge has a protective layer formed by surface treatment of the basic titanium alloy by means of a high-power energy source, such as, in particular, a laser.
摘要:
An intraocular lens comprising a lens body provided with a supporting haptic part formed by at least two filiform elements fixed to the lens and appropriately oriented, each of said filiform elements presenting a length suitable to be laid in a surgically made, non-perforating incision located on the outer surface of the sclera wall of the eye so as to provide a firm anchorage which eliminates any tendency of the lens body to be displaced from the correct position in exact correspondence with the pupil of the eye.