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公开(公告)号：US20100035807A1
公开(公告)日：2010-02-11
申请号：US12304818
申请日：2007-07-25
IPC分类号： A61K38/19 , A61K31/7088 , G01N33/53 , A61P35/00
CPC分类号： A61K31/7105 , A61K9/0019 , A61K48/00 , C12N9/0055 , C12N15/1136 , C12N15/1137 , C12N2310/14 , C12N2799/027 , C12Y110/02002
摘要： The present invention relates to a composition which is useful in the treatment of a tumor, a method for making such a composition, and a method for using such a composition. The invention relates also to a method for assaying for inhibitors of the activity of Core 1 protein and/or other proteins of the respiratory complex III of mitochondria.
摘要翻译： 本发明涉及一种可用于治疗肿瘤的组合物，该组合物的制备方法和使用该组合物的方法。 本发明还涉及用于测定线粒体呼吸复合物III的核心蛋白1和/或其它蛋白质的活性抑制剂的方法。
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公开(公告)号：US08329669B2
公开(公告)日：2012-12-11
申请号：US12304818
申请日：2007-07-25
CPC分类号： A61K31/7105 , A61K9/0019 , A61K48/00 , C12N9/0055 , C12N15/1136 , C12N15/1137 , C12N2310/14 , C12N2799/027 , C12Y110/02002
摘要： The present invention relates to a composition which is useful in the treatment of a tumor, a method for making such a composition, and a method for using such a composition. The invention relates also to a method for assaying for inhibitors of the activity of Core 1 protein and/or other proteins of the respiratory complex III of mitochondria.
摘要翻译： 本发明涉及一种可用于治疗肿瘤的组合物，该组合物的制备方法和使用该组合物的方法。 本发明还涉及用于测定线粒体呼吸复合物III的核心蛋白1和/或其它蛋白质的活性抑制剂的方法。
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公开(公告)号：US09133489B2
公开(公告)日：2015-09-15
申请号：US13496173
申请日：2010-09-13
申请人： Craig A. Behnke , David Molina , Soyan Lieberman , Jamie Bacher , Shuiqin Wu
发明人： Craig A. Behnke , David Molina , Soyan Lieberman , Jamie Bacher , Shuiqin Wu
CPC分类号： C12P7/6409 , C12N9/93 , C12N15/8247 , C12P7/6463 , C12P19/32 , C12Y604/01002
摘要： Provided herein are novel ACCases and nucleotides encoding the same, that when introduced into a cell or organism results in an increase and/or accumulation of fatty acids, glycerol lipids, and/or oils in the cell or organism, and/or a change in the types of fatty acids, glycerol lipids, and/or oils that are normally present in the cell or organism. Also provided herein are organisms transformed with the novel ACCases.
摘要翻译： 本文提供了新的ACCase和编码它的核苷酸，当引入细胞或生物体导致细胞或生物体中脂肪酸，甘油脂质和/或油的增加和/或积累，和/或 通常存在于细胞或生物体中的脂肪酸，甘油脂质和/或油的类型。 本文还提供了用新型ACCases转化的生物体。
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4.发明申请DGAT GENES AND METHODS OF USE FOR TRIGLYCERIDE PRODUCTION IN RECOMBINANT MICROORGANISMS 有权重组微生物中DGAT基因的制备及其生产方法公开(公告)号：US20140106417A1
公开(公告)日：2014-04-17
申请号：US13652934
申请日：2012-10-16
CPC分类号： C12N9/1029 , C12P7/64 , C12P7/6436 , Y02P20/52
摘要： The present invention provides novel diacylglycerol acyltransferase (DGAT) genes, including novel genes encoding localization peptides. The present invention also provides recombinant cells, such as algae, transformed with DGAT genes and methods of using such recombinant cells to produce triglyceride.
摘要翻译： 本发明提供新的二酰基甘油酰基转移酶（DGAT）基因，包括编码定位肽的新基因。 本发明还提供用DGAT基因转化的重组细胞，例如藻类，以及使用这些重组细胞产生甘油三酯的方法。
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公开(公告)号：US20120231546A1
公开(公告)日：2012-09-13
申请号：US13496173
申请日：2010-09-13
申请人： Craig A. Behnke , David Molina , Soyan Lieberman , Jamie Bacher , Shuiqin Wu
发明人： Craig A. Behnke , David Molina , Soyan Lieberman , Jamie Bacher , Shuiqin Wu
CPC分类号： C12P7/6409 , C12N9/93 , C12N15/8247 , C12P7/6463 , C12P19/32 , C12Y604/01002
摘要： Provided herein are novel ACCases and nucleotides encoding the same, that when introduced into a cell or organism results in an increase and/or accumulation of fatty acids, glycerol lipids, and/or oils in the cell or organism, and/or a change in the types of fatty acids, glycerol lipids, and/or oils that are normally present in the cell or organism. Also provided herein are organisms transformed with the novel ACCases.
摘要翻译： 本文提供了新的ACCase和编码它的核苷酸，当引入细胞或生物体导致细胞或生物体中脂肪酸，甘油脂质和/或油的增加和/或积累，和/或 通常存在于细胞或生物体中的脂肪酸，甘油脂质和/或油的类型。 本文还提供了用新型ACCases转化的生物体。
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6.发明授权DGAT genes and methods of use for triglyceride production in recombinant microorganisms 有权DGAT基因和重组微生物中甘油三酯生产的使用方法公开(公告)号：US09328336B2
公开(公告)日：2016-05-03
申请号：US13652934
申请日：2012-10-16
CPC分类号： C12N9/1029 , C12P7/64 , C12P7/6436 , Y02P20/52
摘要： The present invention provides diacylglycerol acyltransferase (DGAT) genes, including genes encoding localization peptides. The present invention also provides recombinant cells, such as algae, transformed with DGAT genes and methods of using such recombinant cells to produce triglyceride.
摘要翻译： 本发明提供了二酰基甘油酰基转移酶（DGAT）基因，包括编码定位肽的基因。 本发明还提供用DGAT基因转化的重组细胞，例如藻类，以及使用这些重组细胞产生甘油三酯的方法。
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