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公开(公告)号：US07615554B2
公开(公告)日：2009-11-10
申请号：US11340430
申请日：2006-01-25
申请人： Robert Selliah , Longwu Qi , Paul B. Robbins , Sudhir R. Sahasrabudhe , Brent R. Stockwell , Raj Gopal Venkat
发明人： Robert Selliah , Longwu Qi , Paul B. Robbins , Sudhir R. Sahasrabudhe , Brent R. Stockwell , Raj Gopal Venkat
IPC分类号： A61K31/497 , A01N43/62 , C07D243/08 , C07D239/72
CPC分类号： A61K31/495 , C07D239/90 , C07D405/12 , C07D409/12 , G01N33/5011 , G01N33/6872
摘要： The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives.
摘要翻译： 本发明涉及筛选结合配偶体，特别是结合配偶体对于erastin的生物学活性（例如VDAC如VDAC3）的生物学活性的方法。 本发明还提供了有效杀死癌细胞与erastin及相关化合物或衍生物的试剂和方法。
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公开(公告)号：US20090170834A1
公开(公告)日：2009-07-02
申请号：US12086909
申请日：2006-12-22
申请人： Raj Gopal Venkat , Longwu Qi , Michael Pierce , Paul B. Robbins , Sudhir R. Sahasrabudhe , Robert Selliah
发明人： Raj Gopal Venkat , Longwu Qi , Michael Pierce , Paul B. Robbins , Sudhir R. Sahasrabudhe , Robert Selliah
IPC分类号： A61K31/5513 , A61K31/497 , C07D471/00
CPC分类号： C07D487/04 , C07D495/04
摘要： Compounds represented by Structural Formula (I): are useful, for example, in the effective killing or reduction in rate of proliferation of cancer cells, such as in patients suffering from cancer. In addition to the compounds themselves, the invention provides pharmaceutical compositions of the compounds and method of treatment using the compounds.
摘要翻译： 由结构式（I）表示的化合物：例如可有效地杀死或降低癌细胞增殖的速率，例如癌症患者。 除了化合物本身，本发明提供了化合物的药物组合物和使用该化合物的治疗方法。
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公开(公告)号：US20110092489A1
公开(公告)日：2011-04-21
申请号：US12086900
申请日：2006-12-22
申请人： Longwu QI , Raj Gopal Venkat , Michael Pierce , Paul B. Robbins , Sudhir R. Sahasrabudhe , Robert Selliah
发明人： Longwu QI , Raj Gopal Venkat , Michael Pierce , Paul B. Robbins , Sudhir R. Sahasrabudhe , Robert Selliah
IPC分类号： A61K31/551 , C07D239/72 , C07D243/08 , A61K31/497 , C12N5/071 , A61P35/00
CPC分类号： C07D239/91
摘要： Compounds represented by Structural Formula (I): are useful, for example, in the effective killing or reducing the rate of proliferation of cancer cells, such as in patients suffering from cancer. In addition to the compounds themselves, the invention provides pharmaceutical compositions of the compounds and method of treatment using the compounds.
摘要翻译： 由结构式（I）表示的化合物可用于例如有效杀死或降低癌细胞增殖的速率，例如患有癌症的患者。 除了化合物本身，本发明提供了化合物的药物组合物和使用该化合物的治疗方法。
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公开(公告)号：US20090214465A1
公开(公告)日：2009-08-27
申请号：US11883092
申请日：2006-01-25
申请人： Robert R. Becklin , Cindy Lou Chepanoske , John M. Peltier , Longwu Qi , Paul B. Robbins , Sudhir R. Sahasrabudhe , Robert Selliah , Keith Simmon , Brent R. Stockwell , Raj Gopal Venkat , Moritz von Rechenberg , Eugene Y. Zhen
发明人： Robert R. Becklin , Cindy Lou Chepanoske , John M. Peltier , Longwu Qi , Paul B. Robbins , Sudhir R. Sahasrabudhe , Robert Selliah , Keith Simmon , Brent R. Stockwell , Raj Gopal Venkat , Moritz von Rechenberg , Eugene Y. Zhen
IPC分类号： A61K38/20 , A61K31/496 , A61K38/21 , A61K39/395 , C12N5/00 , C07D239/72 , C12Q1/68 , C12Q1/02 , G01N33/53 , A61K38/16 , A61K31/7052 , C07D243/08 , C07D403/02 , A61K31/551 , A61K31/55 , A61P35/00
CPC分类号： A61K31/495 , C07D239/90 , C07D405/12 , C07D409/12 , G01N33/5011 , G01N33/6872
摘要： The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives.
摘要翻译： 本发明涉及筛选结合配偶体，特别是结合配偶体对于erastin的生物学活性（例如VDAC如VDAC3）的生物学活性的方法。 本发明还提供了有效杀死癌细胞与erastin及相关化合物或衍生物的试剂和方法。
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公开(公告)号：US08575143B2
公开(公告)日：2013-11-05
申请号：US12086900
申请日：2006-12-22
申请人： Longwu Qi , Raj Gopal Venkat , Michael Pierce , Paul B. Robbins , Sudhir R. Sahasrabudhe , Robert Selliah
发明人： Longwu Qi , Raj Gopal Venkat , Michael Pierce , Paul B. Robbins , Sudhir R. Sahasrabudhe , Robert Selliah
IPC分类号： A01N55/02 , C07D239/70 , C07D223/00
CPC分类号： C07D239/91
摘要： Compounds represented by Structural Formula (I): are useful, for example, in the effective killing or reducing the rate of proliferation of cancer cells, such as in patients suffering from cancer. In addition to the compounds themselves, the invention provides pharmaceutical compositions of the compounds and method of treatment using the compounds.
摘要翻译： 由结构式（I）表示的化合物可用于例如有效杀死或降低癌细胞增殖的速率，例如患有癌症的患者。 除了化合物本身，本发明提供了化合物的药物组合物和使用该化合物的治疗方法。
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公开(公告)号：US08518959B2
公开(公告)日：2013-08-27
申请号：US11883092
申请日：2006-01-25
申请人： Robert R. Becklin , Cindy Lou Chepanoske , John M. Peltier , Longwu Qi , Paul B. Robbins , Sudhir R. Sahasrabudhe , Robert Selliah , Keith Simmon , Brent R. Stockwell , Raj Gopal Venkat , Moritz von Rechenberg , Eugene Y. Zhen
发明人： Robert R. Becklin , Cindy Lou Chepanoske , John M. Peltier , Longwu Qi , Paul B. Robbins , Sudhir R. Sahasrabudhe , Robert Selliah , Keith Simmon , Brent R. Stockwell , Raj Gopal Venkat , Moritz von Rechenberg , Eugene Y. Zhen
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： A61K31/495 , C07D239/90 , C07D405/12 , C07D409/12 , G01N33/5011 , G01N33/6872
摘要： The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related compounds or derivatives.
摘要翻译： 本发明涉及筛选结合配偶体，特别是结合配偶体对于erastin的生物学活性（例如VDAC如VDAC3）的生物学活性的方法。 本发明还提供了有效杀死癌细胞与erastin及相关化合物或衍生物的试剂和方法。
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公开(公告)号：US20110123486A1
公开(公告)日：2011-05-26
申请号：US12665676
申请日：2008-06-25
IPC分类号： A61K38/20 , A61K31/517 , A61K31/551 , A61K31/519 , C12N5/09 , A61K33/36 , A61K33/24 , A61K39/395 , A61K38/21 , A61K31/675 , A61K31/7068 , A61P35/00
CPC分类号： A61K31/517 , A61K31/454 , A61K31/495 , A61K31/551 , A61K31/704 , A61K38/05 , A61K45/06 , C07D239/90
摘要： Erastin analogs are useful in treating various cancers, particularly multiple myeloma. Erastin analogs are also useful in treating cancers that are resistant to other anticancer agents.
摘要翻译： 擦除蛋白类似物可用于治疗各种癌症，特别是多发性骨髓瘤。 埃拉斯汀类似物也可用于治疗对其它抗癌剂具有抗性的癌症。
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公开(公告)号：US5919631A
公开(公告)日：1999-07-06
申请号：US682245
申请日：1996-07-17
CPC分类号： G01N33/6896
摘要： A method of determining the degree of aggregation of the .beta.A4 peptide is disclosed. The method comprises reacting the protein with a suitable binding agent which is capable of binding the .beta.A4 peptide only in its non-aggregated state to form an amount of protein bound binding reagent. The amount of protein bound binding agent is then measured.
摘要翻译： 公开了确定β4A肽聚集度的方法。 该方法包括使蛋白质与合适的结合剂反应，该结合剂能够仅在其非聚集状态下结合βA4肽以形成一定量的蛋白结合结合试剂。 然后测量蛋白结合结合剂的量。
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9.发明申请公开(公告)号：US20090136561A1
公开(公告)日：2009-05-28
申请号：US12288458
申请日：2008-10-20
申请人： Moritz von Rechenberg , John M. Peltier , Sudhir R. Sahasrabudhe , Srdjan Askovic , Robert Selliah , Thomas Zarembinski
发明人： Moritz von Rechenberg , John M. Peltier , Sudhir R. Sahasrabudhe , Srdjan Askovic , Robert Selliah , Thomas Zarembinski
IPC分类号： A61L27/54 , A61K31/352 , A61K31/47 , A61K31/4409 , C12N5/00 , A61P21/00 , C12Q1/02 , C07D215/12 , C07D311/02 , C07D213/56
CPC分类号： A61K31/00 , A61K31/352 , A61K31/433 , A61K31/4409
摘要： The present invention provides compositions and methods for modulating smooth muscle cells. The present invention also provides methods of identifying small molecule candidate therapeutic agents for modulating smooth muscle.
摘要翻译： 本发明提供调节平滑肌细胞的组合物和方法。 本发明还提供鉴定用于调节平滑肌的小分子候选治疗剂的方法。
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