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    Biofunctional, antimicrobial coatings for medical devices
    2.
    发明授权
    Biofunctional, antimicrobial coatings for medical devices 失效
    用于医疗器械的生物功能性抗菌涂层

    公开(公告)号：US07608581B2

    公开(公告)日：2009-10-27

    申请号：US11638973

    申请日：2006-12-14

    申请人： Paul Hamilton ,  Daniel Kenan ,  Mark Grinstaff

    发明人： Paul Hamilton ,  Daniel Kenan ,  Mark Grinstaff

    IPC分类号： C07K14/00

    CPC分类号： A61L27/227 ,  A61K38/00 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/404 ,  A61L2300/606 ,  C07K7/08 ,  C07K14/001 ,  C08L89/00

    摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is an interfacial biomaterial or biofunctional coating composition comprising at least one binding domain that has bind specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for an antimicrobial composition. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating.

    摘要翻译： 本发明提供用于医疗装置的改进涂层的组合物和方法。 本发明提供了一种界面生物材料或生物功能性涂料组合物，其包含至少一个对医疗器械的表面材料具有结合特异性的结合结构域和至少一个对抗微生物组合物具有结合特异性的结合结构域。 用于涂覆医疗装置的表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的表面与生物功能性涂层接触。

    Biofunctional, antimicrobial coatings for medical devices
    3.
    发明申请
    Biofunctional, antimicrobial coatings for medical devices 失效
    用于医疗器械的生物功能性抗菌涂层

    公开(公告)号：US20070104758A1

    公开(公告)日：2007-05-10

    申请号：US11638973

    申请日：2006-12-14

    申请人： Paul Hamilton ,  Daniel Kenan ,  Mark Grinstaff

    发明人： Paul Hamilton ,  Daniel Kenan ,  Mark Grinstaff

    IPC分类号： A61F2/02

    CPC分类号： A61L27/227 ,  A61K38/00 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/404 ,  A61L2300/606 ,  C07K7/08 ,  C07K14/001 ,  C08L89/00

    摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is an interfacial biomaterial or biofunctional coating composition comprising at least one binding domain that has bind specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for an antimicrobial composition. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating.

    摘要翻译： 本发明提供用于医疗装置的改进涂层的组合物和方法。 本发明提供了一种界面生物材料或生物功能性涂料组合物，其包含至少一个对医疗器械的表面材料具有结合特异性的结合结构域和至少一个对抗微生物组合物具有结合特异性的结合结构域。 用于涂覆医疗装置的表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的表面与生物功能性涂层接触。

    Compositions and methods for promoting attachment of cells of endothelial cell lineage to medical devices
    4.
    发明申请
    Compositions and methods for promoting attachment of cells of endothelial cell lineage to medical devices 失效
    促进内皮细胞谱系细胞附着于医疗器械的组合物和方法

    公开(公告)号：US20070166350A1

    公开(公告)日：2007-07-19

    申请号：US11649935

    申请日：2007-01-05

    申请人： Paul Hamilton ,  Daniel Kenan ,  Amy Solan

    发明人： Paul Hamilton ,  Daniel Kenan ,  Amy Solan

    IPC分类号： A61F2/02 ,  C07K14/705 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61L27/34 ,  A61L31/10 ,  C07K7/06 ,  C07K7/08 ,  C07K2319/00

    摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a metallic surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a metallic surface of a medical device, and for manufacturing of a medical device, comprise contacting the metallic surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.

    摘要翻译： 本发明提供用于医疗装置的改进涂层的组合物和方法。 本发明提供一种生物功能性涂料组合物，其包含至少一个对医疗器械的金属表面材料具有结合特异性的结合结构域和至少一个对内皮细胞谱系细胞具有结合特异性的结合结构域。 用于涂覆医疗装置的金属表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的金属表面与生物功能性涂层接触，并且还可以包括使涂覆的表面与 内皮细胞谱系的细胞将内皮细胞谱系的细胞结合到包被的表面。

    Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices
    5.
    发明申请
    Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices 失效
    促进内皮细胞谱系细胞附着于医疗器械的方法和组合物

    公开(公告)号：US20070160644A1

    公开(公告)日：2007-07-12

    申请号：US11649950

    申请日：2007-01-05

    申请人： Daniel Kenan ,  Paul Hamilton

    发明人： Daniel Kenan ,  Paul Hamilton

    IPC分类号： A61F2/02 ,  C07K14/705 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61L27/34 ,  A61L31/10 ,  C07K7/06 ,  C07K7/08

    摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.

    摘要翻译： 本发明提供用于医疗装置的改进涂层的组合物和方法。 本发明提供一种生物功能性涂料组合物，其包含至少一个对医疗装置的表面材料具有结合特异性的结合结构域和至少一个对内皮细胞谱系细胞具有结合特异性的结合结构域。 用于涂覆医疗装置的表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的表面与生物功能性涂层材料接触，并且还可以包括使涂覆的表面与 内皮细胞谱系将内皮细胞谱系的细胞与涂层表面结合。

    Paired basis swap risk and credit mitigation system and collateral minimization system
    6.
    发明授权
    Paired basis swap risk and credit mitigation system and collateral minimization system 有权

    公开(公告)号：US08429058B2

    公开(公告)日：2013-04-23

    申请号：US12559083

    申请日：2009-09-14

    申请人： J. Scott Perry ,  Wallace C. Turbeville ,  Paul Hamilton

    发明人： J. Scott Perry ,  Wallace C. Turbeville ,  Paul Hamilton

    IPC分类号： G06Q40/00

    CPC分类号： G06Q40/06 ,  G06Q20/102 ,  G06Q40/02 ,  G06Q40/04

    摘要： A paired basis swap risk and credit mitigation system and collateral minimization system. In swaps used to hedge forward contracts a system authority interposes itself and forms paired basis swaps with each of the paired swap participants and itself together with a Swaption to allow it to maintain a level book in the event of a default by any counterparty. In the event of a default the system authority has the ability to either terminate a swap and pay the non-defaulting counterparty an agreed upon termination payment, terminate the non-defaulting counterparty's swap and exercise the swaption to substitute a correlated swap with appropriate correlated termination payment; or substitute a new counterparty with an identical swap as the paired swap participant. Paired basis swap control through delivery can be enabled to continue the risk and credit mitigation benefits of the system.

    PAIRED BASIS SWAP RISK AND CREDIT MITIGATION SYSTEM AND COLLATERAL MINIMIZATION SYSTEM
    8.
    发明申请
    PAIRED BASIS SWAP RISK AND CREDIT MITIGATION SYSTEM AND COLLATERAL MINIMIZATION SYSTEM 有权
    配对基础交换风险和信用减缓系统和收敛最小化系统

    公开(公告)号：US20090327160A1

    公开(公告)日：2009-12-31

    申请号：US12559083

    申请日：2009-09-14

    申请人： J. Scott Perry ,  Wallace C. Turbeville ,  Paul Hamilton

    发明人： J. Scott Perry ,  Wallace C. Turbeville ,  Paul Hamilton

    IPC分类号： G06Q40/00

    CPC分类号： G06Q40/06 ,  G06Q20/102 ,  G06Q40/02 ,  G06Q40/04

    摘要： A paired basis swap risk and credit mitigation system and collateral minimization system. In swaps used to hedge forward contracts a system authority interposes itself and forms paired basis swaps with each of the paired swap participants and itself together with a Swaption to allow it to maintain a level book in the event of a default by any counterparty. In the event of a default the system authority has the ability to either terminate a swap and pay the non-defaulting counterparty an agreed upon termination payment, terminate the non-defaulting counterparty's swap and exercise the swaption to substitute a correlated swap with appropriate correlated termination payment; or substitute a new counterparty with an identical swap as the paired swap participant. Paired basis swap control through delivery can be enabled to continue the risk and credit mitigation benefits of the system.

    摘要翻译： 配对的基础互换风险和信贷减免系统和抵押最小化系统。 在用于对冲远期合约的互换中，系统管理机构将其自身置换并与每个配对掉期参与者及其自身一起进行配对的基本互换以及交换，以允许其在任何交易对手违约的情况下维护一个级别的账簿。 在违约的情况下，系统管理机构有能力终止互换并向未违约交易对手方支付约定的终止支付，终止非违约交易对手的掉期，并行使交换以适当的相关终止替代相关掉期 付款; 或用与配对互换参与者相同的交换替代新交易对手。 可以通过交付配对的基础互换控制来继续系统的风险和信贷减免优势。

    Paired basis swap risk and credit mitigation system and collateral minimization system
    9.
    发明授权
    Paired basis swap risk and credit mitigation system and collateral minimization system 有权
    配对基础互换风险和信用减免系统和抵押最小化系统

    公开(公告)号：US07590588B2

    公开(公告)日：2009-09-15

    申请号：US10764126

    申请日：2004-01-23

    申请人： J. Scott Perry ,  Wallace C. Turbeville ,  Paul Hamilton

    发明人： J. Scott Perry ,  Wallace C. Turbeville ,  Paul Hamilton

    IPC分类号： G06Q40/00

    CPC分类号： G06Q40/06 ,  G06Q20/102 ,  G06Q40/02 ,  G06Q40/04

    摘要： A paired basis swap risk and credit mitigation system and collateral minimization system. In swaps used to hedge forward contracts a system authority interposes itself and forms paired basis swaps with each of the paired swap participants and itself together with a Swaption to allow it to maintain a level book in the event of a default by any counterparty. In the event of a default the system authority has the ability to either terminate a swap and pay the non-defaulting counterparty an agreed upon termination payment, terminate the non-defaulting counterparty's swap and exercise the swaption to substitute a correlated swap with appropriate correlated termination payment; or substitute a new counterparty with an identical swap as the paired swap participant. Paired basis swap control through delivery can be enabled to continue the risk and credit mitigation benefits of the system.

    摘要翻译： 配对的基础互换风险和信贷减免系统和抵押最小化系统。 在用于对冲远期合约的互换中，系统管理机构将其自身置换并与每个配对掉期参与者及其自身一起进行配对的基本互换以及交换，以允许其在任何交易对手违约的情况下维护一个级别的账簿。 在违约的情况下，系统管理机构有能力终止互换并向未违约交易对手方支付约定的终止支付，终止非违约交易对手的掉期，并行使交换以适当的相关终止替代相关掉期 付款; 或用与配对互换参与者相同的交换替代新交易对手。 可以通过交付配对的基础互换控制来继续系统的风险和信贷减免优势。