摘要:
The present invention is directed to small interfering RNA molecules targeted against a gene of interest in respiratory epithelial cells, and methods of using these RNA molecules.
摘要:
The present invention employs an iterative application of BLAST and Hidden Markov Model (HMM) based searches which identified 34 β-defensin genes in the human genome and 48 in the mouse genome. The present invention relates to novel antimicrobial peptides and derivatives thereof as well as the β-defensin genes encoding the peptides. The invention further relates to methods of use of the peptides including a method of inhibiting microbial growth by administering an effective amount of the peptide alone or in combination with other antimicrobial agents or antibiotics.
摘要:
The present invention concerns compositions and methods related to the use of peptides and polypeptides corresponding to all or part of the SPLUNC1 and LPLUNC1 proteins. Particular aspects of the invnetion include the use of SPLUNC1 and LPLUNC1 peptides and polypeptides as antimicrobials, anti-inflammatory, and immune modulatory agents.
摘要:
Disclosed are methods for inhibiting TNFα expression, IL-1β expression, iNOS expression, and NF-κB activity and methods for treating autoimmune disease, cancer, or atherosclerosis with a compound of the following formula:
摘要:
Automated malware signature generation is disclosed. Automated malware signature generation includes monitoring incoming unknown files for the presence of malware and analyzing the incoming unknown files based on both a plurality of classifiers of file behavior and a plurality of classifiers of file content. An incoming file is classified as having a particular malware classification based on the analyzing of incoming unknown files and a malware signature is generated for the incoming unknown file based on the particular malware classification. Access is provided to the malware signature.
摘要:
Automated malware signature generation is disclosed. Automated malware signature generation includes monitoring incoming unknown files for the presence of malware and analyzing the incoming unknown files based on both a plurality of classifiers of file behavior and a plurality of classifiers of file content. An incoming file is classified as having a particular malware classification based on the analyzing of incoming unknown files and a malware signature is generated for the incoming unknown file based on the particular malware classification. Access is provided to the malware signature.
摘要:
Compound of Formula A and pharmaceutically acceptable salts thereof and crystalline Forms I and II of Compound of Formula A! Also, methods for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods for their uses.
摘要:
Pyrimidine compounds of the following formula: wherein R1, R2, R3, R4, R5, X, Q1, Q2, and Q3 are defined herein. Also disclosed is a method of treating cancer with one of these compounds.