TML polynucleotides
    1.
    发明申请
    TML polynucleotides 审中-公开
    TML多核苷酸

    公开(公告)号:US20080194484A1

    公开(公告)日:2008-08-14

    申请号:US12009230

    申请日:2008-01-16

    CPC分类号: C07K14/575 A61K38/00

    摘要: The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies, host cells expressing the cDNA encoding the novel TML peptides and methods for increasing gastric motility and secretion of digestive proteins and hormones using the novel TML peptides.

    摘要翻译: 本发明涉及用于标记为TML肽的新型肽片段的多核苷酸,肽,变体及其用途。 肽片段的结合已显示在肾脏和小肠中。 本发明还包括激动剂,拮抗剂,变体,抗体,表达编码新型TML肽的cDNA的宿主细胞和使用新型TML肽增加消化蛋白和激素的胃动力和分泌的方法。

    TML peptides
    3.
    发明授权
    TML peptides 有权
    TML肽

    公开(公告)号:US06627729B1

    公开(公告)日:2003-09-30

    申请号:US09404417

    申请日:1999-09-23

    IPC分类号: C07K706

    CPC分类号: C07K14/575 A61K38/00

    摘要: The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies, host cells expressing the cDNA encoding the novel TML peptides and methods for increasing gastric motility and secretion of digestive proteins and hormones using the novel TML peptides.

    摘要翻译: 本发明涉及用于标记为TML肽的新型肽片段的多核苷酸,肽,变体及其用途。 肽片段的结合已经显示在肾脏和小肠中。 本发明还包括激动剂,拮抗剂,变体,抗体,表达编码新型TML肽的cDNA的宿主细胞和使用新型TML肽增加消化蛋白和激素的胃动力和分泌的方法。

    Methods of using motilin homologs
    7.
    发明授权
    Methods of using motilin homologs 有权
    使用胃动素同系物的方法

    公开(公告)号:US07977309B2

    公开(公告)日:2011-07-12

    申请号:US12075821

    申请日:2008-03-13

    IPC分类号: A61K38/10 C07K14/63

    CPC分类号: C07K14/575 A61K38/00

    摘要: The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.

    摘要翻译: 本发明涉及多核苷酸,多肽及其肽片段及其与胃动素同源性的新cDNA序列的用途。 新型多肽的mRNA的组织分布特异于胃,小肠和胰腺。 本发明还包括激动剂,拮抗剂,抗体,表达编码新型胃动素同系物的cDNA的宿主细胞和使用新分子增加胃动力的方法。

    Short gastrointestinal peptides
    9.
    发明授权
    Short gastrointestinal peptides 失效
    短消化道肽

    公开(公告)号:US06420521B1

    公开(公告)日:2002-07-16

    申请号:US09608810

    申请日:2000-06-30

    IPC分类号: G01N3353

    摘要: The present invention is directed to polynucleotides, polypeptides, peptides, variants and uses thereof for novel peptide fragments which have homology to motilin. Tissue distribution of the mRNA for the novel polypeptide fragment is specific to the stomach, small intestine and pancreas. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies and host cells expressing the cDNA encoding the novel Short Gastrointestinal Peptides (SGIP) peptide.

    摘要翻译: 本发明涉及与胃动素同源的新型肽片段的多核苷酸,多肽,肽,变体和用途。 新型多肽片段的mRNA的组织分布特异于胃,小肠和胰腺。 肽片段的结合已显示在肾脏和小肠中。 本发明还包括表达编码新型短胃肠肽(SGIP)肽的cDNA的激动剂,拮抗剂,变体,抗体和宿主细胞。