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1.发明申请SUBSTITUTED INDOLIN-2-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS 失效取代的吲哚啉-2-酮衍生物及其作为P38激活的激酶激酶抑制剂公开(公告)号：US20110046097A1
公开(公告)日：2011-02-24
申请号：US12989696
申请日：2009-04-16
IPC分类号： A61K31/423 , C07D413/04 , C07D491/107 , C07D491/20 , C07D471/04 , C07D413/14 , A61K31/437 , A61K31/5377 , A61K31/416 , A61K31/573 , A61K31/4985 , A61P35/00 , A61P29/00 , A61P9/10 , A61P9/00 , A61P11/00 , A61P1/00 , A61P19/10 , A61P25/28 , A61P17/06 , A61P19/02
CPC分类号： C07D413/04 , C07D491/107 , C07D491/20
摘要： The present disclosure is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), processes for preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译： 本公开涉及具有通式（I）的p38丝裂原活化蛋白激酶的新抑制剂，其制备方法，其药物组合物及其使用方法。
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2.发明授权Substituted indolin-2-one derivatives and their use as P38 mitogen-activated kinase inhibitors 失效取代的二氢吲哚-2-酮衍生物及其作为P38丝裂原活化激酶抑制剂的用途公开(公告)号：US08450341B2
公开(公告)日：2013-05-28
申请号：US12989696
申请日：2009-04-16
IPC分类号： A01N43/42 , A01N43/82 , A01N43/38 , A61K31/44 , A61K31/41 , A61K31/40 , A61K31/405 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02 , C07D271/06 , C07D271/12 , C07D413/00 , C07D498/00 , C07D261/20 , C07D249/00 , C07D487/02 , C07D495/02 , C07D497/02 , C07D405/00 , C07D409/00 , C07D411/00 , C07D209/36
CPC分类号： C07D413/04 , C07D491/107 , C07D491/20
摘要： The present disclosure is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), processes for preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译： 本公开涉及具有通式（I）的p38丝裂原活化蛋白激酶的新抑制剂，其制备方法，其药物组合物及其使用方法。
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![3-([1,2,4]triazolo[4,3-a]pyridin-7-yl)benzamide derivatives](/abs-image/US/2012/09/04/US08258122B2/abs.jpg.150x150.jpg)
3.发明授权公开(公告)号：US08258122B2
公开(公告)日：2012-09-04
申请号：US12529490
申请日：2008-02-29
IPC分类号： A61K31/56 , A61K31/437 , A61K31/5377 , A61K31/506 , C07D471/04 , C07D413/14 , C07D401/14 , A61P37/02 , A61P19/02 , A61P25/00 , A61P9/00 , A61P1/00
CPC分类号： C07D471/04
摘要： New inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) are disclosed herein, as well as processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy.
摘要翻译： 本文公开了具有通式（I）的p38丝裂原活化蛋白激酶的新抑制剂，以及其制备方法，包含它们的药物组合物及其在治疗中的用途。
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![3-([1,2,4]TRIAZOLO [4,3-A]PYRIDIN-7-YL)BENZAMIDE DERIVATIVES](/abs-image/US/2010/05/13/US20100120731A1/abs.jpg.150x150.jpg)
4.发明申请3-([1,2,4]TRIAZOLO [4,3-A]PYRIDIN-7-YL)BENZAMIDE DERIVATIVES 有权3 - （[1,2,4]三唑并[4,3-A]吡啶-7-YL）苯甲酰胺衍生物公开(公告)号：US20100120731A1
公开(公告)日：2010-05-13
申请号：US12529490
申请日：2008-02-29
IPC分类号： A61K31/56 , C07D471/04 , A61K31/437 , C07D413/14 , A61K31/5377 , C07D401/14 , A61K31/506 , A61P37/02 , A61P19/02 , A61P25/00 , A61P9/00 , A61P11/00 , A61P1/00 , A61P29/00 , A61P19/10 , A61P25/28 , A61P17/06 , A61P9/10 , A61P35/00
CPC分类号： C07D471/04
摘要： New inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) are disclosed herein, as well as processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy.
摘要翻译： 本文公开了具有通式（I）的p38丝裂原活化蛋白激酶的新抑制剂，以及其制备方法，包含它们的药物组合物及其在治疗中的用途。
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5.发明申请PYRIDIN-2(1H)-ONE DERIVATIVES USEFUL AS MEDICAMENTS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS, TRANSPLANT REJECTION, IMMUNE-MEDIATED AND INFLAMMATORY DISEASES 审中-公开吡哩啶-2（1H） - 酮衍生物有助于治疗失语性疾病的药物，移植物免疫，免疫介导和炎症疾病公开(公告)号：US20140170110A1
公开(公告)日：2014-06-19
申请号：US14119920
申请日：2012-05-21
IPC分类号： C07D473/28 , A61K45/06 , A61K31/444 , A61K31/5377 , A61K31/522 , C07D471/04
CPC分类号： C07D473/28 , A61K31/444 , A61K31/522 , A61K31/5377 , A61K45/06 , C07D471/02 , C07D471/04 , C07D473/00
摘要： Compounds having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
摘要翻译： 公开了具有式（I）化学结构的化合物; 以及其制备方法，包含它们的药物组合物及其在治疗中作为Janus Kinases（JAK）抑制剂的用途。
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公开(公告)号：US20130089512A1
公开(公告)日：2013-04-11
申请号：US13704302
申请日：2011-06-14
IPC分类号： C07D519/00 , A61K31/5377 , A61K38/21 , A61K31/59 , A61K31/785 , A61K31/277 , A61K38/13 , A61K31/439 , A61K31/137 , A61K31/58 , A61K31/4704 , A61K31/522 , A61K39/395
CPC分类号： C07D519/00 , A61K31/137 , A61K31/277 , A61K31/439 , A61K31/4704 , A61K31/522 , A61K31/5377 , A61K31/58 , A61K31/59 , A61K31/785 , A61K38/13 , A61K38/215 , A61K39/3955 , C07D487/04
摘要： New heteroaryl imidazolone derivatives having the chemical structure of formula (I) are disclosed, as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
摘要翻译： 公开了具有式（I）化学结构的新的杂芳基咪唑啉酮衍生物及其制备方法，包含它们的药物组合物及其作为Janus Kinases（JAK）抑制剂的治疗中的用途。
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公开(公告)号：US07855202B2
公开(公告)日：2010-12-21
申请号：US12089050
申请日：2006-10-05
申请人： Bernat Vidal Juan , Silvia Fonquerna Pou , Paul Robert Eastwood , Jose Aiguade Bosch , Aranzazu Cardus Figueras , Ines Carranco Moruno , Jacob Gonzalez Rodriguez , Sergio Paredes Aparicio
发明人： Bernat Vidal Juan , Silvia Fonquerna Pou , Paul Robert Eastwood , Jose Aiguade Bosch , Aranzazu Cardus Figueras , Ines Carranco Moruno , Jacob Gonzalez Rodriguez , Sergio Paredes Aparicio
IPC分类号： A61K31/437 , A61K31/506 , A61K31/496 , A61P11/00 , A61P1/00 , A61P9/00 , A61P25/00 , A61P37/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The present disclosure relates to imidazopyridine derivatives of formula (I): The present disclosure also relates to a method for treating a subject afflicted with a pathological condition or disease susceptible to amelioration by antagonism of the A2B adenosine receptor.
摘要翻译： 本公开涉及式（I）的咪唑并吡啶衍生物：本公开还涉及用于治疗受到A2B腺苷受体拮抗作用而易于改善的病理状况或疾病的受试者的治疗方法。
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![Substituted spiro[cycloalkyl-1,3′-indo]-2′(1′H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors](/abs-image/US/2014/07/08/US08772288B2/abs.jpg.150x150.jpg)
8.发明授权Substituted spiro[cycloalkyl-1,3′-indo]-2′(1′H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors 失效取代的螺[环烷基-1,3'-吲哚] -2'（1'H） - 酮衍生物及其作为P38丝裂原活化激酶抑制剂的用途公开(公告)号：US08772288B2
公开(公告)日：2014-07-08
申请号：US12936784
申请日：2009-04-03
IPC分类号： A61K31/403 , A61K31/4178 , A61K31/4196 , A61K31/4245 , A61K31/438 , A61K31/519 , A61K31/5377 , A61K31/4439 , A61K31/437 , A61P29/00 , A61P1/00 , A61P9/00 , A61P17/06 , C07D403/10 , C07D209/96 , C07D413/10 , C07D413/14 , C07D471/10 , C07D487/04 , C07D491/20 , C07D491/107 , C07D495/10 , C07D487/10
CPC分类号： C07D209/34 , C07D209/96
摘要： The present disclosure is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), processes for preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译： 本公开涉及具有通式（I）的p38丝裂原活化蛋白激酶的新抑制剂，其制备方法，其药物组合物及其使用方法。
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公开(公告)号：US20080275038A1
公开(公告)日：2008-11-06
申请号：US12089050
申请日：2006-10-05
申请人： Bernat Vidal Juan , Silvia Fonquerna Pou , Paul Robert Eastwood , Jose Aiguade Bosch , Aranzazu Cardus Figueras , Ines Carranco Moruno , Jacob Gonzalez Rodriguez , Sergio Paredes Aparicio
发明人： Bernat Vidal Juan , Silvia Fonquerna Pou , Paul Robert Eastwood , Jose Aiguade Bosch , Aranzazu Cardus Figueras , Ines Carranco Moruno , Jacob Gonzalez Rodriguez , Sergio Paredes Aparicio
IPC分类号： A61K31/437 , A61P11/00 , A61P1/00 , A61P9/00 , A61P25/00 , A61P37/00 , C07D471/04 , A61K31/506 , A61K31/5377 , A61K31/496 , A61K31/497
CPC分类号： C07D471/04
摘要： The present disclosure relates to imidazopyridine derivatives of formula (I): The present disclosure also relates to a method for treating a subject afflicted with a pathological condition or disease susceptible to amelioration by antagonism of the A2B adenosine receptor.
摘要翻译： 本公开内容涉及式（I）的咪唑并吡啶衍生物：本公开还涉及用于治疗受到Aβ拮抗作用而易于改善的病理状况或疾病的受试者的治疗方法 。
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![SUBSTITUTED SPIRO[CYCLOALKYL-1,3'-INDOL]-2'(1'H)-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS](/abs-image/US/2011/03/03/US20110053936A1/abs.jpg.150x150.jpg)
10.发明申请SUBSTITUTED SPIRO[CYCLOALKYL-1,3'-INDOL]-2'(1'H)-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS 失效取代的SPIRO [CYCLOALKYL-1,3'-INDOL] -2'（1'H） - 酮衍生物及其作为P38 MITOGEN-ACTIVATED KINASE INHIBITORS的用途公开(公告)号：US20110053936A1
公开(公告)日：2011-03-03
申请号：US12936784
申请日：2009-04-03
IPC分类号： A61K31/5377 , C07D491/107 , A61K31/4178 , C07D413/10 , A61K31/4245 , C07D413/14 , C07D471/10 , A61K31/438 , C07D403/10 , A61K31/4196 , C07D491/20 , C07D487/04 , A61K31/519 , C07D495/10 , C07D209/96 , A61K31/403 , A61P29/00 , A61P1/00 , A61P9/10 , A61P17/06
CPC分类号： C07D209/34 , C07D209/96
摘要： The present disclosure is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), processes for preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译： 本公开涉及具有通式（I）的p38丝裂原活化蛋白激酶的新抑制剂，其制备方法，其药物组合物及其使用方法。
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