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    Indolylpiperidine derivatives as antihistaminic and antiallergic agents
    10.
    发明授权
    Indolylpiperidine derivatives as antihistaminic and antiallergic agents 失效
    吲哚基哌啶衍生物作为抗组胺和抗过敏剂

    公开(公告)号：US07189741B2

    公开(公告)日：2007-03-13

    申请号：US10415693

    申请日：2001-10-26

    申请人： Silvia Fonquerna Pou ,  Lluis Pages Santacana ,  Carles Puig Duran ,  Lidia Soca Pueyo

    发明人： Silvia Fonquerna Pou ,  Lluis Pages Santacana ,  Carles Puig Duran ,  Lidia Soca Pueyo

    IPC分类号： A61K31/445 ,  C07D401/14

    CPC分类号： C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

    摘要： The invention relates to indolyl piperidinyl derivatives of formula (I) wherein: A1 represents an alkylene, alkyleneoxy, alkylenethio, alkanoylene or hydroxyalkylene group; A2 represents an alkylene, alkyleneoxy, alkylenethio, alkanoylene or an alkyleneoxyalkylene group; W1 represents a phenylene, furanylene or pyridinylene group which is unsubstituted or substituted by one or more halogen atoms, alkoxy groups and/or alkyl groups; W2 represents a 3–10 membered monocyclic or bicyclic group containing from 1 to 3 heteroatoms said group being unsubstituted or substituted by one or more halogen atoms, alkyl groups, alkoxy groups and/or oxo groups; R1 represents a hydrogen or halogen atom or an alkyl, alkoxy or methylamino group; and R2 represents a carboxyl group; and pharmaceutically acceptable salts thereof; to processes for their preparation; to pharmaceutical compositions containing them; and to their medical use as antihistaminic and antiallergic agents.

    摘要翻译： 本发明涉及式（I）的吲哚基哌啶基衍生物，其中：A 1表示亚烷基，亚烷基氧基，亚烷基硫代，亚烷基或羟基亚烷基; 代表亚烷基，亚烷基氧基，亚烷硫基，亚烷基亚烷基或亚烷基氧亚烷基; W 1表示未被取代或被一个或多个卤素原子，烷氧基和/或烷基取代的亚苯基，呋喃基或亚吡啶基; W 2表示含有1至3个杂原子的3-10元单环或双环，所述基团未被取代或被一个或多个卤素原子，烷基，烷氧基和/或氧代基取代; R 1表示氢或卤素原子或烷基，烷氧基或甲基氨基; R 2表示羧基; 及其药学上可接受的盐; 进行准备; 含有它们的药物组合物; 以及作为抗组胺药和抗过敏剂的医疗用途。