公开(公告)号：US20080102490A1

公开(公告)日：2008-05-01

申请号：US11925097

申请日：2007-10-26

申请人： Paul Sheppard ,  Scott Presnell ,  Brian Fox ,  Teresa Gillbert ,  Betty Haldeman ,  Francis Grant

发明人： Paul Sheppard ,  Scott Presnell ,  Brian Fox ,  Teresa Gillbert ,  Betty Haldeman ,  Francis Grant

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N5/00 ,  C12N5/02 ,  C12N5/04 ,  C12P21/04

CPC分类号： C07K14/47 ,  C07K14/52 ,  C07K2319/00

摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.

摘要翻译： 本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。 本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。

公开(公告)号：US20050106682A1

公开(公告)日：2005-05-19

申请号：US10927815

申请日：2004-08-27

申请人： Paul Sheppard ,  Scott Presnell ,  Brian Fox ,  Teresa Gilbert ,  Betty Haldeman ,  Francis Grant

发明人： Paul Sheppard ,  Scott Presnell ,  Brian Fox ,  Teresa Gilbert ,  Betty Haldeman ,  Francis Grant

IPC分类号： G01N33/53 ,  C07H21/02 ,  C07H21/04 ,  C07K14/47 ,  C07K14/52 ,  C07K14/555 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/99 ,  C12N15/09 ,  C12N15/19 ,  C12N15/21 ,  C12N15/74 ,  C12P21/02 ,  C12P21/04 ,  C12P21/06 ,  C12Q1/68 ,  G01N33/566

CPC分类号： C07K14/47 ,  C07K14/52 ,  C07K2319/00

摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.

公开(公告)号：US20050014228A1

公开(公告)日：2005-01-20

申请号：US10928539

申请日：2004-08-27

申请人： Paul Sheppard ,  Scott Presnell ,  Brian Fox ,  Teresa Gilbert ,  Betty Haldeman ,  Francis Grant

发明人： Paul Sheppard ,  Scott Presnell ,  Brian Fox ,  Teresa Gilbert ,  Betty Haldeman ,  Francis Grant

IPC分类号： G01N33/53 ,  C07H21/02 ,  C07H21/04 ,  C07K14/47 ,  C07K14/52 ,  C07K14/555 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/99 ,  C12N15/09 ,  C12N15/19 ,  C12N15/21 ,  C12N15/74 ,  C12P21/02 ,  C12P21/04 ,  C12P21/06 ,  C12Q1/68 ,  G01N33/566

CPC分类号： C07K14/47 ,  C07K14/52 ,  C07K2319/00

摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.

摘要翻译： 本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。 本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。

公开(公告)号：US20070042468A1

公开(公告)日：2007-02-22

申请号：US11548023

申请日：2006-10-10

申请人： Paul Sheppard ,  Scott Presnell ,  Brian Fox ,  Teresa Gilbert ,  Betty Haldeman ,  Francis Grant

发明人： Paul Sheppard ,  Scott Presnell ,  Brian Fox ,  Teresa Gilbert ,  Betty Haldeman ,  Francis Grant

IPC分类号： C12P21/02 ,  C07H21/04 ,  C07K14/52 ,  C12N1/21 ,  C12N5/04 ,  C12N5/06

CPC分类号： C07K14/47 ,  C07K14/52 ,  C07K2319/00

摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.

公开(公告)号：US20070048841A1

公开(公告)日：2007-03-01

申请号：US11548056

申请日：2006-10-10

申请人： Paul Sheppard ,  Scott Presnell ,  Brian Fox ,  Teresa Gilbert ,  Betty Haldeman ,  Francis Grant

发明人： Paul Sheppard ,  Scott Presnell ,  Brian Fox ,  Teresa Gilbert ,  Betty Haldeman ,  Francis Grant

IPC分类号： C12P21/04 ,  C07H21/04 ,  C12N5/06 ,  C07K14/56

CPC分类号： C07K14/47 ,  C07K14/52 ,  C07K2319/00

摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.

公开(公告)号：US20070049736A1

公开(公告)日：2007-03-01

申请号：US11548138

申请日：2006-10-10

申请人： Paul Sheppard ,  Scott Presnell ,  Brian Fox ,  Teresa Gilbert ,  Betty Haldeman ,  Francis Grant

发明人： Paul Sheppard ,  Scott Presnell ,  Brian Fox ,  Teresa Gilbert ,  Betty Haldeman ,  Francis Grant

IPC分类号： C07K16/24

CPC分类号： C07K14/47 ,  C07K14/52 ,  C07K2319/00

摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.

公开(公告)号：US20070043209A1

公开(公告)日：2007-02-22

申请号：US11548108

申请日：2006-10-10

申请人： Paul Sheppard ,  Scott Presnell ,  Brian Fox ,  Teresa Gilbert ,  Betty Haldeman ,  Francis Grant

发明人： Paul Sheppard ,  Scott Presnell ,  Brian Fox ,  Teresa Gilbert ,  Betty Haldeman ,  Francis Grant

IPC分类号： C07K16/24

CPC分类号： C07K14/47 ,  C07K14/52 ,  C07K2319/00

摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.

摘要翻译： 本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。 本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。

公开(公告)号：US20050106680A1

公开(公告)日：2005-05-19

申请号：US10927891

申请日：2004-08-27

申请人： Paul Sheppard ,  Scott Presnell ,  Brian Fox ,  Teresa Gilbert ,  Betty Haldeman ,  Francis Grant

发明人： Paul Sheppard ,  Scott Presnell ,  Brian Fox ,  Teresa Gilbert ,  Betty Haldeman ,  Francis Grant

IPC分类号： G01N33/53 ,  C07H21/02 ,  C07H21/04 ,  C07K14/47 ,  C07K14/52 ,  C07K14/555 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/99 ,  C12N15/09 ,  C12N15/19 ,  C12N15/21 ,  C12N15/74 ,  C12P21/02 ,  C12P21/04 ,  C12P21/06 ,  C12Q1/68 ,  G01N33/566

CPC分类号： C07K14/47 ,  C07K14/52 ,  C07K2319/00

摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.

公开(公告)号：US20070066811A1

公开(公告)日：2007-03-22

申请号：US11559108

申请日：2006-11-13

申请人： Betty Haldeman ,  Edward Thayer ,  Paul Sheppard

发明人： Betty Haldeman ,  Edward Thayer ,  Paul Sheppard

IPC分类号： C07K16/24

CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K2319/00

摘要： Novel zacrp3x2 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. Also disclosed are antibodies to the zacrp3x2 protein or fragments thereof.

摘要翻译： 公开了新的zacrp3x2多肽，编码多肽的多核苷酸，以及相关的组合物和方法。 还公开了针对zacrp3x2蛋白或其片段的抗体。

公开(公告)号：US20050214791A1

公开(公告)日：2005-09-29

申请号：US10970713

申请日：2004-10-20

申请人： Paul Sheppard ,  Scott Presnell

发明人： Paul Sheppard ,  Scott Presnell

IPC分类号： C07K14/47 ,  C07K14/52 ,  C12N1/21 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/04 ,  C12N15/09

CPC分类号： C07K14/52 ,  C07K14/47 ,  C07K2319/00

摘要： The present invention provides to polynucleotides and secreted proteins encoded by the polynucleotides. The proteins include a variety of fusion proteins, including fusions comprising a signal peptide selected from the group consisting of signal peptides shown in SEQ ID NO:M, wherein M is an even integer from 2 to 328, operably linked to a second polypeptide. The invention further provides therapeutic and diagnostic methods utilizing the polynucleotides, polypeptides, and antagonists of the polypeptides.

摘要翻译： 本发明提供了由多核苷酸编码的多核苷酸和分泌的蛋白质。 蛋白质包括多种融合蛋白，包括融合物，其包含选自SEQ ID NO：M所示的信号肽的信号肽，其中M为2至328的偶数整数，可操作地连接到第二多肽。 本发明还提供了利用多肽的多核苷酸，多肽和拮抗剂的治疗和诊断方法。