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10 条记录 (耗时 0.042 秒)

    N,N-dimethyldiatrizoic acid and its conjugates as hepatobiliary agents for x-ray CT imaging
    8.
    发明授权
    N,N-dimethyldiatrizoic acid and its conjugates as hepatobiliary agents for x-ray CT imaging 失效
    N，N-二甲基二异辛酸及其共轭物作为X线CT成像的肝胆药

    公开(公告)号：US06264916B1

    公开(公告)日：2001-07-24

    申请号：US09484840

    申请日：2000-01-18

    申请人： Rama S. Ranganathan ,  Thangavel Arunachalam ,  Michael F. Tweedle

    发明人： Rama S. Ranganathan ,  Thangavel Arunachalam ,  Michael F. Tweedle

    IPC分类号： A61K4904

    CPC分类号： A61K49/0447 ,  A61K49/0438

    摘要： Compounds having formulae I, II or/III, or pharmaceutically acceptable salts thereof, R1, R2, R3, R4, R5, R6, R7 and R8 are the same or different and are hydrogen, alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, haloalkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or carboxamido alkyl with the proviso that in formula I R2 and R3 cannot be methyl; and m, n and p are the same or different and are 0-24 with the proviso that m+n≦24, are useful as contrast agents in x-ray imaging compositions and methods.

    摘要翻译： 具有式I，II或/ III的化合物或其药学上可接受的盐，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8相同或不同，为氢，烷基，取代或未取代的环烷基，取代或未取代的 芳烷基，取代或未取代的芳基，卤代烷基，羟基烷基，烷氧基烷基，羧基烷基或甲酰氨基烷基，条件是式I中R 2和R 3不能为甲基; andm，n和p相同或不同，并且0-24，条件是m + n <= 24，可用作x射线成像组合物和方法中的造影剂。

    N,N-dimethyldiatrizoic acid and its conjugates as hepatobiliary agents for X-ray CT imaging
    10.
    发明授权
    N,N-dimethyldiatrizoic acid and its conjugates as hepatobiliary agents for X-ray CT imaging 有权
    N，N-二甲基二异辛酸及其共轭物作为X线CT成像的肝胆药

    公开(公告)号：US6051210A

    公开(公告)日：2000-04-18

    申请号：US273522

    申请日：1999-03-22

    申请人： Rama S. Ranganathan ,  Thangavel Arunachalam ,  Michael F. Tweedle

    发明人： Rama S. Ranganathan ,  Thangavel Arunachalam ,  Michael F. Tweedle

    IPC分类号： A61K49/04 ,  A61B8/13

    CPC分类号： A61K49/0447 ,  A61K49/0438

    摘要： Compounds having formulae I, II or III, or pharmaceutically acceptable salts thereof, ##STR1## wherein ##STR2## R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are the same or different and are hydrogen, alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, haloalkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or carboxamido alkyl with the proviso that in formula I R.sub.2 and R.sub.3 cannot be methyl; andm, n and p are the same or different and are 0-24 with the proviso that m+n.ltoreq.24, are useful as contrast agents in x-ray imaging compositions and methods.

    摘要翻译： 具有式I，II或III的化合物或其药学上可接受的盐，其中R1，R2，R3，R4，R5，R6，R7和R8相同或不同，为氢，烷基，取代或未取代的环烷基，取代或未取代的 芳烷基，取代或未取代的芳基，卤代烷基，羟基烷基，烷氧基烷基，羧基烷基或甲酰氨基烷基，条件是式I中R 2和R 3不能为甲基; 并且m，n和p相同或不同，并且0-24，条件是m + n = 24，可用作x射线成像组合物和方法中的造影剂。