公开(公告)号：US20080053434A1

公开(公告)日：2008-03-06

申请号：US11663210

申请日：2005-09-20

申请人： Paul Wightman ,  Andrew Atkinson ,  Ben Wightman ,  Jane Shepherd

发明人： Paul Wightman ,  Andrew Atkinson ,  Ben Wightman ,  Jane Shepherd

IPC分类号： A61B1/32 ,  A61C17/10

CPC分类号： A61B5/097 ,  A61M16/0488 ,  A61M16/0493 ,  A61M16/0666 ,  A61M16/085 ,  A61M2025/022 ,  A61M2230/432

摘要： A mouth prop for insertion in use between the opposed tooth or gum regions of the patient's mandible or maxilla to space the patient's incisors thereapart, the mouth prop having a grippable portion which a clinician can use for assisting in the location and removal of the mouth prop and can be supplied with elements for delivering and/or sampling gases to or in the mouth and/or nasal region of a patient.

摘要翻译： 用于在患者的下颌骨或上颌骨的相对的牙齿或牙龈区域之间插入使用的口腔支架，以将病人的门齿放置在那里，口支架具有可抓握部分，临床医生可以使用该夹持部分来辅助口腔支架的位置和移除 并且可以提供用于将气体输送和/或取样到患者的口部和/或鼻部区域中或之中的元件。

公开(公告)号：USD531314S1

公开(公告)日：2006-10-31

申请号：US29228336

申请日：2005-04-22

申请人： Andrew Atkinson ,  Benjamin Wightman ,  Paul Wightman ,  Jane Shepherd

设计人： Andrew Atkinson ,  Benjamin Wightman ,  Paul Wightman ,  Jane Shepherd

公开(公告)号：US07516568B2

公开(公告)日：2009-04-14

申请号：US11890917

申请日：2007-08-07

申请人： Paul Wightman

发明人： Paul Wightman

IPC分类号： G09D3/00

CPC分类号： B42D5/04 ,  G09D3/00

摘要： A calendar is formed of a plurality of substrates. A first substrate carries indicia thereon which identifies selected time periods, such as days or months of the year. A second substrate is positioned adjacent to the first substrate. The second substrate defines a plurality of cavities dimensioned to individually retain a respective information carrying article, such as a web. Each of the cavities is corresponding supplied with a respective information carrying article. Each indicia on the first substrate is positionally associated with a respective cavity in the second substrate. A third substrate, positioned adjacent to the second substrate, is positioned to retain the information carrying articles releasably within the second substrate. The third substrate provides a rupturable cover over each of the cavities of the second substrate whereby upon the application of a sufficient lateral force on the information carrying article within a selected cavity, the article passes through the cover to a location wherein the article may be retrieved by the user. The lateral force may be applied by the user's finger or alternatively a tool or other object adapted for the application of such force.

摘要翻译： 日历由多个基板形成。 第一底物在其上携带标识其上的标记，其选择时间段，例如一年中的几天或几个月。 第二衬底被定位成与第一衬底相邻。 第二基板限定多个空腔，其尺寸被设计成单独地保持相应的信息传送物品，例如卷筒纸。 每个空腔对应地提供有相应的信息携带物品。 第一基板上的每个标记位置地与第二基板中的相应空腔相关联。 定位成邻近第二基底定位的第三基底被定位成将信息携带物品可释放地保持在第二基底内。 第三基板在第二基板的每个空腔上提供可破裂的盖，由此当在所选择的空腔内对信息携带物品施加足够的横向力时，物品通过盖到达可以取回物品的位置 由用户 侧向力可以由使用者的手指或替代地适用于施加这种力的工具或其他物体施加。

公开(公告)号：US20060189644A1

公开(公告)日：2006-08-24

申请号：US10595066

申请日：2004-08-12

申请人： Paul Wightman

发明人： Paul Wightman

IPC分类号： A61K31/4745 ,  C07D471/02

CPC分类号： C07D471/04 ,  C07D471/14

摘要： Lipid-modified immune response modifier compounds, pharmaceutical compositions containing the compounds and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

摘要翻译： 公开了脂质修饰的免疫应答调节剂化合物，含有这些化合物的药物组合物和这些化合物作为免疫调节剂的用途，用于在动物中诱导或抑制细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：US07937860B2

公开(公告)日：2011-05-10

申请号：US12386237

申请日：2009-04-14

申请人： Paul Wightman

发明人： Paul Wightman

IPC分类号： G09D3/00

CPC分类号： B42D5/04 ,  G09D3/00 ,  Y10T29/49826

摘要： A dispensing device, such as a calendar is formed of a plurality of substrates. A first substrate carries indicia thereon which identifies selected time periods, such as days or months of the year. A second substrate is positioned adjacent to the first substrate. The second substrate defines a plurality of cavities dimensioned to individually retain a respective information carrying article, such as a web. Each of the cavities is corresponding supplied with a respective information carrying article. Each indicia on the first substrate is positionally associated with a respective cavity in the second substrate. A third substrate, positioned adjacent to the second substrate, is positioned to retain the information carrying articles releasably within the second substrate. The third substrate provides a rupturable cover over each of the cavities of the second substrate whereby upon the application of a sufficient lateral force on the information carrying article within a selected cavity, the article passes through the cover to a location wherein the article may be retrieved by the user. The lateral force may be applied by the user's finger or alternatively a tool or other object adapted for the application of such force.

摘要翻译： 诸如日历的分配装置由多个基板形成。 第一底物在其上携带标识其上的标记，其选择时间段，例如一年中的几天或几个月。 第二衬底被定位成与第一衬底相邻。 第二基板限定多个空腔，其尺寸被设计成单独地保持相应的信息传送物品，例如卷筒纸。 每个空腔对应地提供有相应的信息携带物品。 第一基板上的每个标记位置地与第二基板中的相应空腔相关联。 定位成邻近第二基底定位的第三基底被定位成将信息携带物品可释放地保持在第二基底内。 第三基板在第二基板的每个空腔上提供可破裂的盖，由此当在所选择的空腔内对信息携带物品施加足够的横向力时，物品通过盖到达可以取回物品的位置 由用户 侧向力可以由使用者的手指或替代地适用于施加这种力的工具或其他物体施加。

公开(公告)号：US20080028645A1

公开(公告)日：2008-02-07

申请号：US11890917

申请日：2007-08-07

申请人： Paul Wightman

发明人： Paul Wightman

IPC分类号： G09D3/00

CPC分类号： B42D5/04 ,  G09D3/00

摘要： A calendar is formed of a plurality of substrates. A first substrate carries indicia thereon which identifies selected time periods, such as days or months of the year. A second substrate is positioned adjacent to the first substrate. The second substrate defines a plurality of cavities dimensioned to individually retain a respective information carrying article, such as a web. Each of the cavities is corresponding supplied with a respective information carrying article. Each indicia on the first substrate is positionally associated with a respective cavity in the second substrate. A third substrate, positioned adjacent to the second substrate, is positioned to retain the information carrying articles releasably within the second substrate. The third substrate provides a rupturable cover over each of the cavities of the second substrate whereby upon the application of a sufficient lateral force on the information carrying article within a selected cavity, the article passes through the cover to a location wherein the article may be retrieved by the user. The lateral force may be applied by the user's finger or alternatively a tool or other object adapted for the application of such force.

摘要翻译： 日历由多个基板形成。 第一底物在其上携带标识其上的标记，其选择时间段，例如一年中的几天或几个月。 第二衬底被定位成与第一衬底相邻。 第二基板限定多个空腔，其尺寸被设计成单独地保持相应的信息传送物品，例如卷筒纸。 每个空腔对应地提供有相应的信息携带物品。 第一基板上的每个标记位置地与第二基板中的相应空腔相关联。 定位成邻近第二基底定位的第三基底被定位成将信息携带物品可释放地保持在第二基底内。 第三基板在第二基板的每个空腔上提供可破裂的盖，由此当在所选择的空腔内对信息携带物品施加足够的横向力时，物品通过盖到达可以取回物品的位置 由用户 侧向力可以由使用者的手指或替代地适用于施加这种力的工具或其他物体施加。

公开(公告)号：US20100018089A1

公开(公告)日：2010-01-28

申请号：US12386237

申请日：2009-04-14

申请人： Paul Wightman

发明人： Paul Wightman

IPC分类号： G09D3/00 ,  B23P11/00

CPC分类号： B42D5/04 ,  G09D3/00 ,  Y10T29/49826

摘要： A dispensing device, such as a calendar is formed of a plurality of substrates. A first substrate carries indicia thereon which identifies selected time periods, such as days or months of the year. A second substrate is positioned adjacent to the first substrate. The second substrate defines a plurality of cavities dimensioned to individually retain a respective information carrying article, such as a web. Each of the cavities is corresponding supplied with a respective information carrying article. Each indicia on the first substrate is positionally associated with a respective cavity in the second substrate. A third substrate, positioned adjacent to the second substrate, is positioned to retain the information carrying articles releasably within the second substrate. The third substrate provides a rupturable cover over each of the cavities of the second substrate whereby upon the application of a sufficient lateral force on the information carrying article within a selected cavity, the article passes through the cover to a location wherein the article may be retrieved by the user. The lateral force may be applied by the user's finger or alternatively a tool or other object adapted for the application of such force.

摘要翻译： 诸如日历的分配装置由多个基板形成。 第一底物在其上携带标识其上的标记，其选择时间段，例如一年中的几天或几个月。 第二衬底被定位成与第一衬底相邻。 第二基板限定多个空腔，其尺寸被设计成单独地保持相应的信息传送物品，例如卷筒纸。 每个空腔对应地提供有相应的信息携带物品。 第一基板上的每个标记位置地与第二基板中的相应空腔相关联。 定位成邻近第二基底定位的第三基底被定位成将信息携带物品可释放地保持在第二基底内。 第三基板在第二基板的每个空腔上提供可破裂的盖，由此当在所选择的空腔内对信息携带物品施加足够的横向力时，物品通过盖到达可以取回物品的位置 由用户 侧向力可以由使用者的手指或替代地适用于施加这种力的工具或其他物体施加。

公开(公告)号：US20060155214A1

公开(公告)日：2006-07-13

申请号：US10525757

申请日：2003-08-28

申请人： Paul Wightman

发明人： Paul Wightman

IPC分类号： A61B5/00 ,  B65D81/00

CPC分类号： A61F5/455

摘要： A urine collection device for attachment to a pump and for a user in a supine, or reclined position, includes: an open-mouthed container having a rim around the mouth for being urged in use to seat generally around the periphery of the urine discharge region to receive urine discharged from the urethra, the container being adapted to fit between the legs of a user in a supine or reclined position, the container having at its lower part a reservoir basin in which fluid may collect in use when the container is applied to a user in a supine or reclined position, and an outlet in the lower part of the reservoir basin through which urine may be drawn from the container.

摘要翻译： 一种尿液收集装置，用于附接到泵和用于仰卧或倾斜位置的使用者，包括：开口容器，其具有围绕所述口的边缘，用于被推动用于大致围绕所述排尿区域的周围 为了接收从尿道排出的尿液，该容器适于以仰卧位或仰卧位置装配在使用者的腿部之间，该容器在其下部具有储存器池，当将容器应用于容器时，流体可在其中收集使用 卧位或仰卧位的使用者，以及储存池底部的出口，尿液可从容器中抽出。

公开(公告)号：US20060142202A1

公开(公告)日：2006-06-29

申请号：US11360071

申请日：2006-02-23

申请人： Sefik Alkan ,  William Kieper ,  John Vasilakos ,  Jason Bonk ,  George Griesgraber ,  Kenneth Lipson ,  Jie Liu ,  James Mendoza ,  Doris Stoermer ,  Paul Wightman ,  Naiyong Jing ,  William Schultz

发明人： Sefik Alkan ,  William Kieper ,  John Vasilakos ,  Jason Bonk ,  George Griesgraber ,  Kenneth Lipson ,  Jie Liu ,  James Mendoza ,  Doris Stoermer ,  Paul Wightman ,  Naiyong Jing ,  William Schultz

IPC分类号： A61K38/09 ,  A61K31/4745

CPC分类号： A61K31/4745 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851

摘要： The present invention provides immunomodulatory compositions include an immune response modifier moiety coupled to a targeting moiety. In another aspect, the invention provides methods of providing targeted delivery of an IRM, generating a localized immune response, and treating a condition in a subject. Generally, the methods include administering to the subject an immunomodulatory composition that includes an immune response modifier moiety coupled to a targeting moiety that recognizes a delivery target.

摘要翻译： 本发明提供免疫调节组合物包括与靶向部分偶联的免疫应答调节剂部分。 在另一方面，本发明提供了提供IRM的靶向递送，产生局部免疫应答和治疗受试者的病症的方法。 通常，所述方法包括向受试者施用免疫调节组合物，其包含与识别递送目标的靶向部分偶联的免疫应答调节剂部分。

公开(公告)号：US20100314486A1

公开(公告)日：2010-12-16

申请号：US12814663

申请日：2010-06-14

申请人： Paul Wightman

发明人： Paul Wightman

IPC分类号： B65H49/26 ,  B65H16/06

CPC分类号： B65H35/002 ,  B65H35/0073 ,  B65H75/185

摘要： A dispenser for dispensing sheet material from a roll. The roll has a location arrangement for releasably mounting the roll between a spigot and an oppositely facing support element for rotation about a longitudinal axis of the dispenser. The arrangement includes: a core around which the sheet material is wrapped, one end of the core being mounted or mountable relative to the support element, the other end having a wall region defining a generally hollow cylindrical portion projecting from the wrapped material, a generally axial slot being provided in the wall region extending to the free edge thereof; and a fixing provided on the cylindrical portion. The fixing has a bearing surface for rotatably engaging the spigot for rotational movement about the longitudinal axis, and a radial path to the bearing surface, the path being radially aligned with the slot in the core, whereby the end of the core may be laterally engaged with the spigot support element.

摘要翻译： 一种用于从卷筒中分配片材的分配器。 卷具有用于将卷筒可释放地安装在插口和相对面对的支撑元件之间的位置布置，用于围绕分配器的纵向轴线旋转。 所述布置包括：芯片，围绕所述芯材料被包裹，所述芯的一端相对于所述支撑元件安装或安装，所述另一端具有限定从所述包裹材料突出的大致中空的圆柱形部分的壁区域， 轴向槽设置在延伸到其自由边缘的壁区域中; 以及设置在圆筒部上的固定件。 固定件具有用于可旋转地接合插口以用于围绕纵向轴线旋转运动的轴承表面，以及到轴承表面的径向路径，该路径与芯体中的槽径向对准，由此芯部的端部可以横向接合 与插口支撑元件。