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公开(公告)号：US6127151A
公开(公告)日：2000-10-03
申请号：US470590
申请日：1995-06-07
申请人： Pavel Novotny, deceased , by Jaroslava Novotny, administrator , Juan Antonio Montaraz Crespo , Juraj Ivanyi
发明人： Pavel Novotny, deceased , by Jaroslava Novotny, administrator , Juan Antonio Montaraz Crespo , Juraj Ivanyi
IPC分类号： A61K39/095 , A61K31/00 , A61K39/00 , A61K39/02 , A61K39/085 , A61K39/09 , A61K39/10 , A61P31/00 , A61P31/04 , C07K1/00 , C07K1/18 , C07K1/22 , C07K14/235 , C12N9/88 , C12P21/00 , C12P21/04 , C12N13/00
CPC分类号： C07K14/235 , C12N9/88 , A61K39/00 , Y10S530/806 , Y10S530/825
摘要： A method of deriving an antigen from Bordetella pertussis, wherein the antigen is characterized by the following features: a relative molecular weight of about 67,000 to 73,000 as determined by 12%(w/w) polyacrylamide gel electrophoresis and a proline:glutamic acid ratio of about 1:1 as determined by amino acid analysis. The method comprises: (a) culturing Bordetella pertussiscells; (b) treating the culture of (a) to obtain an outer membrane fraction; and (c) isolating the antigen from the outer membrane fraction of (b).
摘要翻译： 从百日咳博德特氏菌衍生抗原的方法，其中所述抗原的特征在于以下特征：通过12％（w / w）聚丙烯酰胺凝胶电泳测定的约67,000至73,000的相对分子量和脯氨酸：谷氨酸比例 约1：1，通过氨基酸分析测定。 该方法包括：（a）培养百日咳杆菌细胞; （b）处理（a）的培养物以获得外膜部分; 和（c）从（b）的外膜部分分离抗原。
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公开(公告)号：US6048700A
公开(公告)日：2000-04-11
申请号：US478046
申请日：1995-06-07
IPC分类号： A61K39/095 , A61K31/00 , A61K39/00 , A61K39/02 , A61K39/085 , A61K39/09 , A61K39/10 , A61P31/00 , A61P31/04 , C07K1/00 , C07K1/18 , C07K1/22 , C07K14/235 , C12N9/88 , C12P21/00 , C12P21/04 , G01N33/53 , G01N33/531 , C01K1/00
CPC分类号： C07K14/235 , C12N9/88 , A61K39/00 , Y10S530/806 , Y10S530/825
摘要： The invention provides a vaccine containing a proteinaceous material derived from the outer membrane of Bordetella pertussis, wherein the proteinaceous material is characterized by a relative molecular weight of about 67,000 to 73,000, preferably 69,000, as determined by 12% (w/w) polyacrylamide gel electrophoresis and a proline:glutamic acid ratio of about 1:1 as determined by amino acid analysis, in a pharmaceutically acceptable carrier or adjuvant. The invention also provides a method of inducing an immune response in an individual involving administering the vaccine of the invention to an individual.
摘要翻译： 本发明提供一种含有衍生自百日咳博德特氏菌外膜的蛋白质物质的疫苗，其中蛋白质物质的特征在于通过12％（w / w）聚丙烯酰胺凝胶测定的相对分子量为约67,000至73,000，优选为69,000 电泳，脯氨酸：通过氨基酸分析确定的约1：1的谷氨酸比例，在药学上可接受的载体或佐剂中。 本发明还提供了在个体中诱导免疫应答的方法，其涉及向个体施用本发明的疫苗。
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公开(公告)号：US06210685B1
公开(公告)日：2001-04-03
申请号：US09334690
申请日：1999-06-17
IPC分类号： A61K3910
CPC分类号： C07K14/235 , A61K39/00 , C12N9/88 , Y10S530/806 , Y10S530/825
摘要： The present invention provides novel antigenic preparations comprising proteinaceous material associated with adenylate cyclase activity in cultures of B. pertussis, the said preparations being useful as components of acellular whooping cough vaccines. The invention further provides methods for the isolation of such antigenic preparations.
摘要翻译： 本发明提供了包含与百日咳杆菌培养物中的腺苷酸环化酶活性相关的蛋白质物质的新型抗原制剂，所述制剂可用作无细胞百日咳疫苗的组分。 本发明还提供了分离这些抗原制剂的方法。
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