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公开(公告)号：US5891917A
公开(公告)日：1999-04-06
申请号：US957260
申请日：1997-10-24
申请人： Peng Cho Tang , Li Sun , Asaad S. Nematalla , Gerald McMahon
发明人： Peng Cho Tang , Li Sun , Asaad S. Nematalla , Gerald McMahon
IPC分类号： C07C311/27 , C07C317/46 , C07D213/71 , C07D333/34 , C07C255/08 , A61K31/18 , C07C255/32
CPC分类号： C07D333/34 , C07C311/27 , C07C317/46 , C07D213/71
摘要： The present invention relates to molecules capable of modulating tyrosine signal transduction to prevent and treat cell proliferative disorders or cell differentiation disorders associated with particular tyrosine kinases by inhibiting one or more abnormal tyrosine kinase activities.
摘要翻译： 本发明涉及能够调节酪氨酸信号转导以通过抑制一种或多种异常酪氨酸激酶活性来预防和治疗与特定酪氨酸激酶相关的细胞增殖性疾病或细胞分化障碍的分子。
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公开(公告)号：US06225346B1
公开(公告)日：2001-05-01
申请号：US09372395
申请日：1999-08-10
申请人： Peng Cho Tang , Li Sun , Asaad S. Nematalla , Gerald McMahon
发明人： Peng Cho Tang , Li Sun , Asaad S. Nematalla , Gerald McMahon
IPC分类号： A61K31275
CPC分类号： C07C311/13 , C07C317/46 , C07D333/34
摘要： The present invention relates to molecules capable of modulating tyrosine signal transduction to prevent and treat cell proliferative disorders or cell differentiation disorders associated with particular tyrosine kinases by inhibiting one or more abnormal tyrosine kinase activities.
摘要翻译： 本发明涉及能够调节酪氨酸信号转导以通过抑制一种或多种异常酪氨酸激酶活性来预防和治疗与特定酪氨酸激酶相关的细胞增殖性疾病或细胞分化障碍的分子。
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公开(公告)号：US5935993A
公开(公告)日：1999-08-10
申请号：US957420
申请日：1997-10-24
申请人： Peng Cho Tang , Li Sun , Asaad S. Nematalla , Gerald McMahon
发明人： Peng Cho Tang , Li Sun , Asaad S. Nematalla , Gerald McMahon
IPC分类号： C07C311/27 , C07C317/46 , C07D213/71 , C07D333/34 , A61K31/38 , C07D307/64
CPC分类号： C07D333/34 , C07C311/27 , C07C317/46 , C07D213/71
摘要： The present invention relates to molecules capable of modulating tyrosine signal transduction to prevent and treat cell proliferative disorders or cell differentiation disorders associated with particular tyrosine kinases by inhibiting one or more abnormal tyrosine kinase activities.
摘要翻译： 本发明涉及能够调节酪氨酸信号转导以通过抑制一种或多种异常酪氨酸激酶活性来预防和治疗与特定酪氨酸激酶相关的细胞增殖性疾病或细胞分化障碍的分子。
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公开(公告)号：US5710173A
公开(公告)日：1998-01-20
申请号：US487089
申请日：1995-06-07
IPC分类号： C07D333/32 , C07D333/34 , C07D333/38 , C07D333/44 , C07D409/12 , A61K31/38 , A61K31/44 , C07D333/42
CPC分类号： C07D409/12 , C07D333/32 , C07D333/34 , C07D333/38 , C07D333/44
摘要： The present invention relates to molecules capable of modulating tyrosine signal transduction to prevent and treat cell proliferative disorders or cell differentiation disorders associated with particular tyrosine kinases by inhibiting one or more abnormal tyrosine kinase activities.
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公开(公告)号：US5886195A
公开(公告)日：1999-03-23
申请号：US971274
申请日：1997-11-17
IPC分类号： C07D333/32 , C07D333/34 , C07D333/38 , C07D333/44 , C07D409/12 , C07D333/12
CPC分类号： C07D409/12 , C07D333/32 , C07D333/34 , C07D333/38 , C07D333/44
摘要： The present invention relates to molecules capable of modulating tyrosine signal transduction to prevent and treat cell proliferative disorders or cell differentiation disorders associated with particular tyrosine kinases by inhibiting one or more abnormal tyrosine kinase activities.
摘要翻译： 本发明涉及能够调节酪氨酸信号转导以通过抑制一种或多种异常酪氨酸激酶活性来预防和治疗与特定酪氨酸激酶相关的细胞增殖性疾病或细胞分化障碍的分子。
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公开(公告)号：US07053114B2
公开(公告)日：2006-05-30
申请号：US10816957
申请日：2004-04-05
申请人： Connie Li Sun , Chung Chen Wei , Peng Cho Tang , Marcel Koenig , Yong Zhou , Tomas Vojkovsky , Asaad S. Nematalla
发明人： Connie Li Sun , Chung Chen Wei , Peng Cho Tang , Marcel Koenig , Yong Zhou , Tomas Vojkovsky , Asaad S. Nematalla
IPC分类号： A61K31/403 , C07D233/02 , A61P35/00
CPC分类号： C07D403/06 , C07D403/14 , C07F9/5728 , C07F9/65583 , C07H15/26
摘要： The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
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7.发明授权公开(公告)号：US06797725B2
公开(公告)日：2004-09-28
申请号：US10118321
申请日：2002-04-09
申请人： Connie Li Sun , Chung Chen Wei , Peng Cho Tang , Marcel Koenig , Yong Zhou , Tomas Vojkovsky , Asaad S. Nematalla
发明人： Connie Li Sun , Chung Chen Wei , Peng Cho Tang , Marcel Koenig , Yong Zhou , Tomas Vojkovsky , Asaad S. Nematalla
IPC分类号： A61K31403
CPC分类号： C07D403/06 , C07D403/14 , C07F9/5728 , C07F9/65583 , C07H15/26
摘要： The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
摘要翻译： 本发明涉及吡咯取代的2-二氢吲哚酮化合物及其药学上可接受的盐，其调节蛋白激酶的活性，因此预期可用于预防和治疗与蛋白激酶相关的细胞病症例如癌症。
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公开(公告)号：US07572924B2
公开(公告)日：2009-08-11
申请号：US11517529
申请日：2006-09-06
申请人： Peng Cho Tang , Todd Anthony Miller , Xiaoyuan Li , Connie Li Sun , Chung Chen Wei , Shahrzad Shirazian , Congxin Liang , Tomas Vojkovsky , Asaad S. Nematalla , Michael Hawley
发明人： Peng Cho Tang , Todd Anthony Miller , Xiaoyuan Li , Connie Li Sun , Chung Chen Wei , Shahrzad Shirazian , Congxin Liang , Tomas Vojkovsky , Asaad S. Nematalla , Michael Hawley
IPC分类号： A61K31/404 , C07D403/06
CPC分类号： C07D233/56 , C07D207/33 , C07D209/44 , C07D231/12 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14
摘要： The present invention relates to pyrrole substituted-2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
摘要翻译： 本发明涉及吡咯取代-2-二氢吲哚酮化合物及其药学上可接受的盐，其调节蛋白激酶的活性，因此预期可用于预防和治疗与蛋白激酶相关的细胞病症例如癌症。
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公开(公告)号：US07125905B2
公开(公告)日：2006-10-24
申请号：US11028477
申请日：2005-01-04
申请人： Peng Cho Tang , Todd A. Miller , Xiaoyuan Li , Li Sun , Chung Chen Wei , Shahrzad Shirazian , Congxin Liang , Tomas Vojkovsky , Asaad S. Nematalla , Michael Hawley
发明人： Peng Cho Tang , Todd A. Miller , Xiaoyuan Li , Li Sun , Chung Chen Wei , Shahrzad Shirazian , Congxin Liang , Tomas Vojkovsky , Asaad S. Nematalla , Michael Hawley
IPC分类号： A61K31/404 , C07D403/06
CPC分类号： C07D233/56 , C07D207/33 , C07D209/44 , C07D231/12 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14
摘要： The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
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公开(公告)号：US06573293B2
公开(公告)日：2003-06-03
申请号：US09783264
申请日：2001-02-15
申请人： Peng Cho Tang , Todd A. Miller , Xiaoyuan Li , Li Sun , Chung Chen Wei , Shahrzad Shirazian , Congxin Liang , Tomas Vojkovsky , Asaad S. Nematalla , Michael Hawley
发明人： Peng Cho Tang , Todd A. Miller , Xiaoyuan Li , Li Sun , Chung Chen Wei , Shahrzad Shirazian , Congxin Liang , Tomas Vojkovsky , Asaad S. Nematalla , Michael Hawley
IPC分类号： A61K31404
CPC分类号： C07D233/56 , C07D207/33 , C07D209/44 , C07D231/12 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14
摘要： The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
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