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    BIOCOMPATIBLE FIBRINOGEN MATRIX ON A SOLID SUPPORT
    1.
    发明申请
    BIOCOMPATIBLE FIBRINOGEN MATRIX ON A SOLID SUPPORT 审中-公开
    生物化学纤维素基质固体支持

    公开(公告)号：US20100015203A1

    公开(公告)日：2010-01-21

    申请号：US12528799

    申请日：2008-02-26

    申请人： Pentti Tengvall ,  Ella Cathrine Vikinge

    发明人： Pentti Tengvall ,  Ella Cathrine Vikinge

    IPC分类号： A61F2/00 ,  A61K31/66 ,  A61K31/675

    CPC分类号： A61L31/16 ,  A61L17/145 ,  A61L31/046 ,  A61L31/10 ,  A61L2300/00

    摘要： The present invention provides a non-clottable matrix on a solid support comprising immobilized and crosslinked fibrinogen. The matrix may further comprise, in and/or on the matrix, one or several biologically active compound(s) and/or pharmacological substance(s). The matrix may be composed of one or several fibrinogen layer(s). The solid support according to the present invention may be selected from the group consisting of orthopaedic devices, implants, stitches, stents, pins, screws, plates, and sutures.

    摘要翻译： 本发明在固体支持物上提供了一种非螯合性基质，其包含固定和交联的纤维蛋白原。 基质还可以在基质中和/或基质上包含一种或几种生物活性化合物和/或药物物质。 基质可以由一种或多种纤维蛋白原层组成。 根据本发明的固体支持物可以选自矫形装置，植入物，针迹，支架，针，螺钉，板和缝线。

    Coated suture thread and production thereof
    2.
    发明申请
    Coated suture thread and production thereof 审中-公开
    涂层缝合线及其生产

    公开(公告)号：US20090177228A1

    公开(公告)日：2009-07-09

    申请号：US11921025

    申请日：2006-02-21

    申请人： Per Vilhelm Aspenberg ,  Pentti Tengvall ,  Björn Pasternak

    发明人： Per Vilhelm Aspenberg ,  Pentti Tengvall ,  Björn Pasternak

    IPC分类号： A61B17/04 ,  B05D3/00

    CPC分类号： A61B17/06166 ,  A61B2017/00893 ,  A61L17/145

    摘要： Disclosed is a coated suture thread comprising a matrix formed by an immobilized and crosslinked plurality of fibrinogen layers into and/or onto which one or several pharmacological substances that inhibit tissue break-down, such as MMP inhibitors and/or corticosteroids and/or COX inhibitors, are attached and/or associated. Further, a method of producing such a coated suture thread as well as the use thereof for suturing damaged tissue, such as damaged tendon, ligament, intestine and/or skin, are described.

    摘要翻译： 公开了一种涂覆缝合线，其包括由固定和交联的多个纤维蛋白原层形成的基质，其形成和/或其上抑制组织分解的一种或多种药理学物质，例如MMP抑制剂和/或皮质类固醇和/或COX抑制剂 ，附加和/或关联。 此外，描述了制造这种涂覆缝合线的方法及其用于缝合损伤的组织，例如损伤的腱，韧带，肠和/或皮肤的用途。

    Bisphosphonate coated implant device and method therefor
    3.
    发明申请
    Bisphosphonate coated implant device and method therefor 有权
    双膦酸酯涂层植入装置及其方法

    公开(公告)号：US20060003917A1

    公开(公告)日：2006-01-05

    申请号：US10534666

    申请日：2004-07-01

    申请人： Per Aspenberg ,  Pentti Tengvall

    发明人： Per Aspenberg ,  Pentti Tengvall

    IPC分类号： A61K38/02

    CPC分类号： A61L27/32 ,  A61L27/34 ,  A61L31/086 ,  A61L31/10 ,  C08L89/00

    摘要： The method of the present invention is for coating an implant device. The implant device is coated with a protein film, such as fibrinogen. A first bisphosphonate substance, such as pamidronate, is immobilized to the protein film. A second bisphosphonate substance, such ibandronate, is adsorbed to the first bisphosphonate wherein the first bisphosphonate is different from the second bisphosphonate.

    摘要翻译： 本发明的方法是用于涂覆植入装置。 植入装置涂覆有蛋白质膜，例如纤维蛋白原。 首先将二膦酸盐物质如帕米膦酸盐固定在蛋白质膜上。 第二二膦酸盐物质，例如伊班膦酸盐被吸附到第一二膦酸盐，其中第一二膦酸盐不同于第二二膦酸盐。

    Determination of polymerization/coagulation in a fluid
    5.
    发明授权
    Determination of polymerization/coagulation in a fluid 有权
    流体中聚合/凝结的测定

    公开(公告)号：US06379976B1

    公开(公告)日：2002-04-30

    申请号：US09622063

    申请日：2000-11-14

    申请人： Pentti Tengvall ,  Ingemar Lundstrom

    发明人： Pentti Tengvall ,  Ingemar Lundstrom

    IPC分类号： G01N3353

    CPC分类号： G01N33/4905 ,  G01N33/04 ,  G01N33/44 ,  Y10S436/805

    摘要： An analytical method of qualitative and optionally quantitative determination of the occurrence of polymerization/coagulation in a fluid containing polymerizable/coagulable components is described. The method comprises the steps of directing incident beams of electromagnetic radiation through a transparent support on which a film of electrically conducting material is placed, to the back of the film, at angles equal to or greater than the critical angle for total reflection, and measuring changes in the reflected beams due to changes in the surface plasmon resonance angle. Repeated measurements are correlated to the occurrence and magnitude of changes with qualitative and optionally quantitative occurrence of polymerization/coagulation in the fluid. The analytical method is not volume dependent since only one (small) surface of the measuring instrument needs to be in contact with the fluid. Further, the method can also be applied to poorly transparent fluids such as blood.

    摘要翻译： 描述了在含可聚合/可凝固组分的流体中定性和任选地定量测定聚合/凝结的发生的分析方法。 该方法包括以下步骤：以等于或大于全反射的临界角的角度将入射的电磁辐射束通过其上放置有导电材料的膜的透明支撑件引导到膜的背面，并且测量 由于表面等离子体共振角的变化，反射光束的变化。 重复的测量与变化的发生和大小相关，定性和任选地定量地发生流体中的聚合/凝结。 分析方法不是体积依赖的，因为只有一个（小）表面的测量仪器需要与流体接触。 此外，该方法还可以应用于不透明的液体如血液。