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公开(公告)号：US07943613B2
公开(公告)日：2011-05-17
申请号：US12097564
申请日：2006-12-21
申请人： Per Sauerberg , Pavel Pihera , Zdenek Polivka , Miroslav Havranek , Ingrid Pettersson , John Patrick Mogensen
发明人： Per Sauerberg , Pavel Pihera , Zdenek Polivka , Miroslav Havranek , Ingrid Pettersson , John Patrick Mogensen
IPC分类号： C07D295/155 , A61K31/5375
CPC分类号： A61K31/5377 , A61K31/192 , A61K31/195 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/415 , A61K31/4402 , A61K31/445 , A61K31/495 , A61K31/5375 , C07C59/70 , C07C217/48 , C07C323/16 , C07C323/32 , C07C2601/02 , C07D211/46 , C07D213/30 , C07D213/36 , C07D231/12 , C07D265/30 , C07D295/096 , C07D295/112 , C07D307/79 , C07D307/81 , C07D333/16 , C07D333/20 , C07D333/54
摘要： Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds are activators of PPARδ and should be useful for treating conditions mediated by the same.
摘要翻译： 通式（I）的新型化合物，这些化合物作为药物组合物的用途，包含该化合物的药物组合物和使用这些化合物和组合物的治疗方法。 本发明化合物是PPARδ的活化剂，可用于治疗由其介导的病症。
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公开(公告)号：US08362016B2
公开(公告)日：2013-01-29
申请号：US13079460
申请日：2011-04-04
申请人： Per Sauerberg , Pavel Pihera , Zdenek Polivka , Miroslav Havranek , Ingrid Pettersson , John Patrick Mogensen
发明人： Per Sauerberg , Pavel Pihera , Zdenek Polivka , Miroslav Havranek , Ingrid Pettersson , John Patrick Mogensen
IPC分类号： A61K31/5375 , C07D295/155
CPC分类号： A61K31/5377 , A61K31/192 , A61K31/195 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/415 , A61K31/4402 , A61K31/445 , A61K31/495 , A61K31/5375 , C07C59/70 , C07C217/48 , C07C323/16 , C07C323/32 , C07C2601/02 , C07D211/46 , C07D213/30 , C07D213/36 , C07D231/12 , C07D265/30 , C07D295/096 , C07D295/112 , C07D307/79 , C07D307/81 , C07D333/16 , C07D333/20 , C07D333/54
摘要： Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds are activators of PPARδ and should be useful for treating conditions mediated by the same.
摘要翻译： 通式（I）的新型化合物，这些化合物作为药物组合物的用途，包含该化合物的药物组合物和使用这些化合物和组合物的治疗方法。 本发明化合物是PPARδ的活化剂，应用于治疗由其介导的病症。
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公开(公告)号：US20110245244A1
公开(公告)日：2011-10-06
申请号：US13079460
申请日：2011-04-04
申请人： Per Sauerberg , Pavel Pihera , Zdenek Polivka , Miroslav Havranek , Ingrid Pettersson , John Patrick Mogensen
发明人： Per Sauerberg , Pavel Pihera , Zdenek Polivka , Miroslav Havranek , Ingrid Pettersson , John Patrick Mogensen
IPC分类号： A61K31/5377 , C07D413/12 , C07D333/60 , A61K31/381 , C07D265/30 , A61K31/5375 , C07D211/62 , A61K31/445 , C07C59/68 , A61K31/192 , C07D213/55 , A61K31/4402 , C07D231/12 , A61K31/415 , C07D241/04 , A61K31/495 , C07D207/04 , A61K31/40 , C07D405/10 , A61K31/4025 , A61P3/10
CPC分类号： A61K31/5377 , A61K31/192 , A61K31/195 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/415 , A61K31/4402 , A61K31/445 , A61K31/495 , A61K31/5375 , C07C59/70 , C07C217/48 , C07C323/16 , C07C323/32 , C07C2601/02 , C07D211/46 , C07D213/30 , C07D213/36 , C07D231/12 , C07D265/30 , C07D295/096 , C07D295/112 , C07D307/79 , C07D307/81 , C07D333/16 , C07D333/20 , C07D333/54
摘要： Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds are activators of PPARδ and should be useful for treating conditions mediated by the same.
摘要翻译： 通式（I）的新型化合物，这些化合物作为药物组合物的用途，包含该化合物的药物组合物和使用这些化合物和组合物的治疗方法。 本发明化合物是PPARδ的活化剂，应用于治疗由其介导的病症。
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公开(公告)号：US20090093484A1
公开(公告)日：2009-04-09
申请号：US12097564
申请日：2006-12-21
申请人： Per Sauerberg , Pavel Pihera , Zdenek Polivka , Miroslav Havranek , Ingrid Pettersson , John Patrick Mogensen
发明人： Per Sauerberg , Pavel Pihera , Zdenek Polivka , Miroslav Havranek , Ingrid Pettersson , John Patrick Mogensen
IPC分类号： A61K31/192 , C07C321/26 , C07D295/182 , C07D213/55 , C07C59/58 , A61P3/10 , C07D231/12 , A61K31/5375 , A61K31/44 , A61K31/415
CPC分类号： A61K31/5377 , A61K31/192 , A61K31/195 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/415 , A61K31/4402 , A61K31/445 , A61K31/495 , A61K31/5375 , C07C59/70 , C07C217/48 , C07C323/16 , C07C323/32 , C07C2601/02 , C07D211/46 , C07D213/30 , C07D213/36 , C07D231/12 , C07D265/30 , C07D295/096 , C07D295/112 , C07D307/79 , C07D307/81 , C07D333/16 , C07D333/20 , C07D333/54
摘要： Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds are activators of PPARδ and should be useful for treating conditions mediated by the same.
摘要翻译： 通式（I）的新型化合物，这些化合物作为药物组合物的用途，包含该化合物的药物组合物和使用这些化合物和组合物的治疗方法。 本发明化合物是PPARδ的活化剂，应用于治疗由其介导的病症。
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5.发明授权Peroxisome proliferator activated receptor-active arylene acetic acid derivatives 有权过氧化物酶体增殖物激活受体活性亚芳基乙酸衍生物公开(公告)号：US07129268B2
公开(公告)日：2006-10-31
申请号：US10693161
申请日：2003-10-24
申请人： Lone Jeppesen , John Patrick Mogensen , Ingrid Pettersson , Per Sauerberg , Pavel Pihera , Miroslav Havranek
发明人： Lone Jeppesen , John Patrick Mogensen , Ingrid Pettersson , Per Sauerberg , Pavel Pihera , Miroslav Havranek
IPC分类号： A61K31/19 , C07C59/48 , C07C69/76 , C07D333/56 , C07D307/38
CPC分类号： C07C323/20 , C07C59/68 , C07C69/712
摘要： Novel compounds of the general formula (I), wherein Ar, R1, R2, X1, X2, Y1, Y, and Z are as defined in the specification, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPARδ subtype.
摘要翻译： 新的通式（I）化合物，其中Ar，R 1，R 2，X 1，X 2， Y 1和Y 1如说明书中所定义，这些化合物作为药物组合物的用途，包含该化合物的药物组合物和使用这些化合物和组合物的治疗方法。 本发明化合物可用于治疗和/或预防由过氧化物酶体增殖物激活受体（PPAR）介导的病症，特别是PPARδ亚型。
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公开(公告)号：US07091245B2
公开(公告)日：2006-08-15
申请号：US10654699
申请日：2003-09-04
IPC分类号： A61K31/19 , C07C315/00
CPC分类号： C07C235/42 , C07C217/76 , C07C317/22 , C07C323/19 , C07C323/20 , C07C323/29 , C07C323/60 , C07C323/65 , C07D213/32
摘要： Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPARδ suptype.
摘要翻译： 通式（I）的新型化合物，这些化合物作为药物组合物的用途，包含该化合物的药物组合物和使用这些化合物和组合物的治疗方法。 本发明化合物可用于治疗和/或预防由过氧化物酶体增殖物激活受体（PPAR）介导的病症，特别是PPARdelta suptype。
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7.发明授权Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives 失效过氧化物酶体增殖物激活受体（PPAR）活性乙烯基羧酸衍生物公开(公告)号：US06869967B2
公开(公告)日：2005-03-22
申请号：US10201456
申请日：2002-07-18
IPC分类号： C07C69/734 , C07D277/24 , A61K31/341 , A61K31/381 , A61K31/426 , C07D307/40
CPC分类号： C07C69/734
摘要： Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPARδ suptype.
摘要翻译： 通式（I）的新型化合物，这些化合物作为药物组合物的用途，包含该化合物的药物组合物和使用这些化合物和组合物的治疗方法。 本发明化合物可用于治疗和/或预防由过氧化物酶体增殖物激活受体（PPAR）介导的病症，特别是PPARdelta suptype。
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8.发明授权Combination therapy using a dual PPAR-α/PPAR-γ activator and a GLP-1 derivative for the treatment of metabolic syndrome and related diseases and disorders 失效使用双重PPAR-α/ PPAR-γ激活剂和GLP-1衍生物治疗代谢综合征和相关疾病和病症的联合疗法公开(公告)号：US07202213B2
公开(公告)日：2007-04-10
申请号：US10442284
申请日：2003-05-20
IPC分类号： A61K38/00
CPC分类号： C07C69/734 , C07C59/68
摘要： The present invention relates to a pharmaceutical composition comprising a dual Peroxisome Proliferator-Activated Receptor-alpha/Peroxisome Proliferator-Activated Receptor-gama activator (PPAR-α/PPAR-γ) and a Glucagon Like Peptide-1 (GLP-1) derivative for treating, preventing and reducing the risk of developing Type 2 diabetes, insulin resistance, dyslipidemia, obesity, hypertension and other related diseases and disorders.
摘要翻译： 本发明涉及一种药物组合物，其包含双过氧化物酶体增殖物激活受体-α/过氧化物酶体增殖物激活受体激动剂（PPAR-α/ PPAR-γ）和胰高血糖素样肽-1（GLP-1）衍生物 治疗，预防和降低发生2型糖尿病，胰岛素抵抗，血脂异常，肥胖，高血压和其他相关疾病和病症的风险。
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公开(公告)号：US06555577B1
公开(公告)日：2003-04-29
申请号：US09770896
申请日：2001-01-26
IPC分类号： A61K31216
CPC分类号： C07D213/30 , A61K31/34 , A61K31/357 , A61K31/435 , A61K45/06 , C07C59/68 , C07C59/72 , C07C59/90 , C07C69/65 , C07C69/734 , C07C2603/18 , C07C2603/26 , C07D215/14 , C07D307/42 , C07D307/79 , C07D307/80 , C07D317/54 , A61K2300/00
摘要： The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).
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公开(公告)号：US07067530B2
公开(公告)日：2006-06-27
申请号：US10217595
申请日：2002-07-29
IPC分类号： C07D215/14 , A61K31/47
CPC分类号： C07D215/14 , C07C229/36 , C07C2603/18
摘要： Novel compounds of general formula (I), the use of these compounds as medicaments, pharmaceuticaly compositions comprising the compounds and methods of treatment employing these compounds and compostiones. The present compounds may be useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR). The compounds exert their effects by modulating the PPARγ response in a partial agonist manner.
摘要翻译： 通式（I）的新型化合物，这些化合物作为药物的用途，包含该化合物的药物组合物和使用这些化合物和组合物的治疗方法。 本发明化合物可用于治疗和/或预防由核受体介导的病症，特别是过氧化物酶体增殖物激活受体（PPAR）。 化合物通过以部分激动剂方式调节PPARγ反应而发挥其作用。
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