公开(公告)号：US20060088659A1

公开(公告)日：2006-04-27

申请号：US11036935

申请日：2005-01-18

申请人： Peter Bonitatebus ,  Havva Acar

发明人： Peter Bonitatebus ,  Havva Acar

IPC分类号： B05D7/00

CPC分类号： B82Y30/00 ,  B82Y25/00 ,  C01G49/0072 ,  C01G49/02 ,  C01G49/06 ,  C01G49/08 ,  C01G51/00 ,  C01P2002/32 ,  C01P2002/72 ,  C01P2004/04 ,  C01P2004/52 ,  C01P2004/64 ,  C09C1/22 ,  C09C1/24 ,  C09C3/08 ,  H01F1/0054 ,  H01F1/0063 ,  H01F1/37

摘要： A method of forming a plurality of monodisperse nanoparticles. Each of the nanoparticles comprises a nanocrystalline inorganic core and at least one outer coating comprising an ionizable stabilizing material that substantially covers the core. The method comprises the steps of: combining a nonpolar aprotic organic solvent, an oxidant, and a first surfactant; providing at least one organometallic compound to the combined nonpolar aprotic organic solvent, oxidant, and first surfactant; and heating the combined nonpolar aprotic organic solvent, oxidant, first surfactant, and the at least one organometallic compound under an inert gas atmosphere to a first temperature in a range from about 30° C. to about 400° C. for a first time interval, thereby reacting the at least one organometallic compound and the oxidant in the presence of the first surfactant and the nonpolar aprotic organic solvent to form a plurality of nanoparticles, each of the plurality of nanoparticles comprising a nanocrystalline inorganic core and at least one outer coating comprising the first surfactant. The at least one organometallic compound comprises a metal and at least one ligand.

摘要翻译： 一种形成多个单分散纳米粒子的方法。 每个纳米颗粒包含纳米晶体无机核和至少一个包含基本覆盖芯的可离子化稳定材料的外涂层。 该方法包括以下步骤：将非极性非质子有机溶剂，氧化剂和第一表面活性剂组合; 向组合的非极性非质子有机溶剂，氧化剂和第一表面活性剂提供至少一种有机金属化合物; 以及在惰性气体气氛下将组合的非极性非质子有机溶剂，氧化剂，第一表面活性剂和至少一种有机金属化合物加热至约30℃至约400℃的第一温度，持续第一时间间隔 从而在第一表面活性剂和非极性非质子有机溶剂的存在下使至少一种有机金属化合物和氧化剂反应以形成多种纳米颗粒，所述多种纳米颗粒中的每一种包含纳米晶体无机核和至少一种外涂层，其包含 第一种表面活性剂。 所述至少一种有机金属化合物包含金属和至少一种配体。

公开(公告)号：US20060018835A1

公开(公告)日：2006-01-26

申请号：US10818235

申请日：2004-04-02

申请人： Patrick Lucien Malenfant ,  Havva Acar ,  Peter Bonitatebus ,  William Dixon ,  Amit Kulkarni

发明人： Patrick Lucien Malenfant ,  Havva Acar ,  Peter Bonitatebus ,  William Dixon ,  Amit Kulkarni

IPC分类号： A61K49/18 ,  A61K9/16 ,  A61K9/50

CPC分类号： A61K49/1848 ,  A61K49/186 ,  B82Y5/00

摘要： An aspect of the invention includes a nanoparticle including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating includes of at least coating structure I, II, or III wherein the nanoparticle is substantially non-agglomerated and has diameter in a range from about 1 nm to about 100 nm. An aspect of the invention also encompasses a method of making a substantially non-agglomerated nanoparticle having a diameter in a range from about 1 nm to about 100 nm including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating comprises coating structure I, II, or III. An aspect of the invention also encompasses various methods of using the substantially non-agglomerated nanoparticle having a diameter in a range from about 1 nm to about 100 nm including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating comprises coating structure I, II, or III.

摘要翻译： 本发明的一个方面包括纳米颗粒，其包括具有表面的基本上单分散的无机核，涂层基本覆盖基本上单分散的无机核的表面，其中该涂层至少包括涂层结构I，II或III，其中纳米颗粒是 基本上非聚集并且具有在约1nm至约100nm范围内的直径。 本发明的一个方面还包括制备直径在约1nm至约100nm范围内的基本上非团聚的纳米颗粒的方法，包括基本上单分散的无机芯，其表面和涂层基本上覆盖基本上 单分散无机芯，其中涂层包括涂层结构I，II或III。 本发明的一个方面还包括使用直径在约1nm至约100nm范围内的基本上未附聚的纳米颗粒的各种方法，包括基本上单分散的无机芯，其表面和基本覆盖基本上表面的涂层 单分散无机芯，其中涂层包括涂层结构I，II或III。

公开(公告)号：US20050260137A1

公开(公告)日：2005-11-24

申请号：US10889618

申请日：2004-07-12

申请人： Havva Acar ,  Faisal Syud ,  Rachel Garaas ,  Peter Bonitatebus ,  Amit Kulkarni

发明人： Havva Acar ,  Faisal Syud ,  Rachel Garaas ,  Peter Bonitatebus ,  Amit Kulkarni

IPC分类号： A61K49/00 ,  A61K49/18

CPC分类号： B82Y5/00 ,  A61K49/1839 ,  A61K49/186

摘要： A contrast agent for magnetic resonance imaging having a plurality of nanoparticles. Each of the nanoparticles has: a signal generating core having a diameter of up to 10 nm; at least one organic layer of at least one of a polymer, a monomer, and a surfactant; and a water soluble outer shell of at least one of a polymer, a monomer, and a ligand. The organic layer is adsorbed upon and substantially surrounds and stabilizes the signal generating core. The water soluble outer shell solubilizes and provides biocompatibility for each of the nanoparticles. The contrast agents provide enhanced relaxivity, high signal-to-noise ratios, and targeting abilities. In addition, the contrast agents possess resistance to agglomeration, controlled particle size, blood clearance rate, and biodistribution. Methods of making such contrast agents and nanoparticles are also disclosed.

摘要翻译： 一种用于具有多个纳米颗粒的磁共振成像的造影剂。 每个纳米颗粒具有：具有高达10nm的直径的信号产生芯; 聚合物，单体和表面活性剂中的至少一种的至少一种有机层; 以及聚合物，单体和配体中的至少一种的水溶性外壳。 有机层被吸附在基本上并且基本上包围和稳定信号产生芯。 水溶性外壳增溶并提供每种纳米颗粒的生物相容性。 造影剂提供增强的松弛度，高信噪比和靶向能力。 此外，造影剂具有抗凝集，受控粒度，血清清除率和生物分布。 还公开了制备这种造影剂和纳米颗粒的方法。

公开(公告)号：US20060105052A1

公开(公告)日：2006-05-18

申请号：US10989632

申请日：2004-11-15

申请人： Havva Acar ,  Andrew Torres

发明人： Havva Acar ,  Andrew Torres

IPC分类号： A61K48/00 ,  C12N15/87 ,  A61K9/50

CPC分类号： A61K9/5115 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/1848 ,  A61K49/1851 ,  B82Y5/00

摘要： A cationic nanoparticle having an inorganic core and at least one outer cationic coating is described. The at least one outer cationic coating substantially covers the inorganic core and has at least one organo-silane. The organo-silane includes: —Si(R1)3 wherein R1independently at each occurrence is an alkoxy group, a hydroxyl group, a halide, an alkyl group, or hydrogen, and wherein at least one R1 of the three R1s is not an alkyl group. A nanocomplex having a cationic nanoparticle and at least one oligonucleotide attached to the cationic nanoparticle is also described. Methods of making cationic nanoparticles and nanocomplexes are also described. Also described are methods of delivering an oligonucleotide into a cell in-vitro, to a subject in-vivo, and monitoring the delivery of an oligonucleotide.

摘要翻译： 描述了具有无机核和至少一个外部阳离子涂层的阳离子纳米颗粒。 所述至少一种外部阳离子涂层基本上覆盖所述无机芯并且具有至少一种有机硅烷。 有机硅烷包括：<？in-line-formula description =“In-line Formulas”end =“lead”→Si（R 1）3 < 在线公式描述=“在线公式”end =“tail”？>其中R 1在每次出现时独立地是烷氧基，羟基，卤素，烷基 或氢，并且其中三个R 1的至少一个R 1不是烷基。 还描述了具有阳离子纳米颗粒和连接至阳离子纳米颗粒的至少一个寡核苷酸的纳米复合物。 还描述了制备阳离子纳米颗粒和纳米复合物的方法。 还描述了在体内将寡核苷酸递送到细胞体内的方法，并监测寡核苷酸的递送。

公开(公告)号：US07071282B2

公开(公告)日：2006-07-04

申请号：US10454006

申请日：2003-06-03

申请人： Havva Acar ,  Daniel Joseph Brunelle

发明人： Havva Acar ,  Daniel Joseph Brunelle

IPC分类号： C08G73/10 ,  C08G69/28 ,  C08L77/00

CPC分类号： C08G73/1085 ,  C08G73/1053 ,  C08G73/18

摘要： Disclosed herein are polyetherimide compositions comprising structural units of the formula: derived from at least one benzimidazole diamine, wherein R1 and R2 are independently selected from hydrogen and C1–C6 alkyl groups; “A” comprises structural units of the formulae: or mixtures of the foregoing structural units; wherein “D” is a divalent aromatic group, R3 and R10–R12 are independently selected from hydrogen, halogen, and C1–C6 alkyl groups; “q” is an integer having a value of 1 up to the number of positions available on the aromatic ring for substitution; and “W” is a linking group; and “B” comprises substituted and unsubstituted arylene groups having from about 6 to about 25 carbon atoms. Methods for producing the polyetherimide compositions are also disclosed herein.

摘要翻译： 本文公开了包含下式结构单元的聚醚酰亚胺组合物：衍生自至少一种苯并咪唑二胺，其中R 1和R 2独立地选自氢和C 1 -C 6烷基， C 1 -C 6烷基; “A”包括下列结构单元：或前述结构单元的混合物; 其中“D”是二价芳族基团，R 3和R 10 -R 12独立地选自氢，卤素和C 1-4烷基， C 1 -C 6烷基; C 1 -C 6烷基; “q”是具有值为1的整数，直到芳环上取代的可用位置数; 和“W”是连接基团; “B”包括具有约6至约25个碳原子的取代和未取代的亚芳基。 本文还公开了制备聚醚酰亚胺组合物的方法。

公开(公告)号：US20070043203A1

公开(公告)日：2007-02-22

申请号：US11210164

申请日：2005-08-22

申请人： Qing Ye ,  David Hall ,  William Richards ,  Daniel Brunelle ,  Havva Acar

发明人： Qing Ye ,  David Hall ,  William Richards ,  Daniel Brunelle ,  Havva Acar

IPC分类号： C08G69/08

CPC分类号： C08G73/1046 ,  C08G73/124

摘要： Copolyetherimides compositions having high glass transition temperatures and outstanding ductility are presented. The copolyetherimides having Mw of at least 40,000 comprising isomeric bis(phthalimide) structural units within a relatively narrow range of isomer proportions exhibited Tgs of at least 240° C. and outstanding Notched Izod values. The copolyetherimides comprise oxydianiline residues and structural units of the formulas (I) and (II) (III). The copolyetherimides are characterized by a mole percentage of structural units derived from 4,4′-biphenol in a range from about 55% to about 85% of all bisphenol-derived structural units present in the copolyetherimide composition; a mole percentage of structural units derived from bisphenol A in a range from about 45% to about 15% of all bisphenol-derived structural units present in the copolyetherimide composition; and a total mole percentage of structural units derived from bisphenol A or 4,4′-biphenol of at least 95% of all bisphenol-derived structural units present in the copolyetherimide composition.

摘要翻译： 提出了具有高玻璃化转变温度和优异延展性的共聚酰亚胺组合物。 具有至少40,000的含有异构双（邻苯二甲酰亚胺）结构单元的异构体双组分（邻苯二甲酰亚胺）结构单元的共聚醚酰亚胺具有至少240℃的Tg和优异的缺口伊佐德值。 共聚醚酰亚胺包括氧化二苯胺残基和式（I）和（II）（III）的结构单元。 共聚醚酰亚胺的特征在于衍生自4,4'-联苯酚的结构单元的百分比在共聚醚酰亚胺组合物中存在的所有双酚衍生的结构单元的约55％至约85％的范围内; 来自双酚A的结构单元的摩尔百分比在存在于共聚醚酰亚胺组合物中的所有双酚衍生的结构单元的约45％至约15％的范围内; 并且衍生自双酚A或4,4'-联苯酚的结构单元的总摩尔百分比为存在于共聚醚酰亚胺组合物中的所有双酚衍生的结构单元的至少95％。

公开(公告)号：US20060173158A1

公开(公告)日：2006-08-03

申请号：US11363681

申请日：2006-02-28

申请人： Daniel Brunelle ,  Havva Acar ,  Farid Khouri ,  Thomas Guggenheim ,  David Woodruff ,  Norman Johnson

发明人： Daniel Brunelle ,  Havva Acar ,  Farid Khouri ,  Thomas Guggenheim ,  David Woodruff ,  Norman Johnson

IPC分类号： C08G8/02 ,  C08G75/00 ,  C07D401/00

CPC分类号： C08G73/12 ,  C08G73/121 ,  C08G73/124

摘要： Polyether polymers, such as polyetherimides, are prepared by the reaction of a dihydroxy-substituted aromatic hydrocarbon alkali metal salt, such as bisphenol A disodium salt, with a bis(N-(chlorophthalimido))aromatic compound, such as 1,3- and/or 1,4-bis(N-(4-chlorophthalimido))benzene, in a solvent such as o-dichlorobenzene and in the presence of a phase transfer catalyst such as a hexaalkylguanidinium chloride. Several embodiments may be employed to improve the method. They comprise employing substantially dry reagents, employing a high solids level in solvent, beginning with an excess of bis(N-(chlorophthalimido))-aromatic compound and incrementally adding alkali metal salt, employing alkali metal salt of small particle size, and using reagents of high purity.

摘要翻译： 聚醚聚合物如聚醚酰亚胺通过二羟基取代的芳族烃碱金属盐如双酚A二钠盐与双（N-（氯代邻苯二甲酰亚胺基））芳族化合物如1,3-和 /或1,4-双（N-（4-氯邻苯二甲酰亚氨基））苯，在溶剂如邻二氯苯中，并在相转移催化剂如六烷基氯化the存在下进行。 可以采用几个实施例来改进该方法。 它们包括使用基本上干的试剂，在溶剂中使用高固体含量，从过量的双（N-（氯代邻苯二甲酰亚胺基）） - 芳族化合物开始，并逐渐加入碱金属盐，使用小粒径的碱金属盐，并使用试剂 的高纯度。