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1.发明申请公开(公告)号：US20130060011A1
公开(公告)日：2013-03-07
申请号：US13591010
申请日：2012-08-21
CPC分类号： C07K16/468 , C07K2317/55 , C07K2317/66
摘要： The present invention relates to bispecific antibodies comprising at least two fab fragments, wherein the first Fab fragment comprises at least one antigen binding site specific for a first antigen; and the second Fab fragment comprises at least one antigen binding site specific for a second antigen, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and wherein the bispecific antibody is devoid of a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及包含至少两个fab片段的双特异性抗体，其中第一Fab片段包含至少一个对第一抗原特异的抗原结合位点; 并且所述第二Fab片段包含至少一个针对第二抗原特异性的抗原结合位点，其中所述第二Fab重链和轻链的可变区或恒定区被交换; 并且其中所述双特异性抗体缺乏Fc结构域; 其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20130058937A1
公开(公告)日：2013-03-07
申请号：US13591028
申请日：2012-08-21
申请人： Johannes Auer , Peter Bruenker , Tanja Fauti , Christiane Jaeger , Christian Klein , Wolfgang Schaefer , Claudio Sustmann , Pablo Umana
发明人： Johannes Auer , Peter Bruenker , Tanja Fauti , Christiane Jaeger , Christian Klein , Wolfgang Schaefer , Claudio Sustmann , Pablo Umana
IPC分类号： A61K39/395 , C12N15/63 , C12N5/10 , A61P35/00 , C12N1/21 , C12P21/02 , C07K16/46 , C12N15/13 , C12N1/19
CPC分类号： C07K16/2809 , C07K16/3053 , C07K16/468 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/92 , C07K2319/00
摘要： The present invention generally relates to novel bispecific antigen binding molecules. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
摘要翻译： 本发明一般涉及新的双特异性抗原结合分子。 此外，本发明涉及编码这种双特异性抗原结合分子的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。 本发明还涉及用于产生本发明的双特异性抗原结合分子的方法以及在治疗疾病中使用这些双特异性抗原结合分子的方法。
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3.发明申请BISPECIFIC ANTIBODIES SPECIFIC FOR T-CELL ACTIVATING ANTIGENS AND A TUMOR ANTIGEN AND METHODS OF USE 审中-公开T细胞活化抗原和肿瘤抗原的特异性抗体及其使用方法公开(公告)号：US20150274845A1
公开(公告)日：2015-10-01
申请号：US14269950
申请日：2014-05-05
申请人： Peter Bruenker , Tanja Fauti , Christiane Jaeger , Christian Klein , Pablo Umana
发明人： Peter Bruenker , Tanja Fauti , Christiane Jaeger , Christian Klein , Pablo Umana
CPC分类号： C07K16/468 , C07K16/2809 , C07K16/30 , C07K16/3053 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/66
摘要： The present invention relates to bispecific antibodies that specifically bind a T-cell activating antigen and a Tumor Antigen (TA), comprising a first Fab fragment and a second Fab fragment, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and wherein the bispecific antibody does not comprise a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及特异性结合T细胞活化抗原和肿瘤抗原（TA）的双特异性抗体，其包含第一Fab片段和第二Fab片段，其中第二Fab重链的可变区或恒定区和 轻链交换; 并且其中所述双特异性抗体不包含Fc结构域; 其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20130078249A1
公开(公告)日：2013-03-28
申请号：US13590886
申请日：2012-08-21
申请人： Oliver Ast , Peter Bruenker , Tanja Fauti , Anne Freimoser-Grundschober , Christiane Jaeger , Christian Klein , Ekkehard Moessner , Pablo Umana
发明人： Oliver Ast , Peter Bruenker , Tanja Fauti , Anne Freimoser-Grundschober , Christiane Jaeger , Christian Klein , Ekkehard Moessner , Pablo Umana
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , C07K16/2809 , C07K16/2863 , C07K16/3007 , C07K16/3053 , C07K16/40 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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5.发明申请公开(公告)号：US20130058936A1
公开(公告)日：2013-03-07
申请号：US13591024
申请日：2012-08-21
申请人： Peter Bruenker , Tanja Fauti , Christiane Jaeger , Christian Klein , Pablo Umana
发明人： Peter Bruenker , Tanja Fauti , Christiane Jaeger , Christian Klein , Pablo Umana
CPC分类号： C07K16/468 , C07K16/2809 , C07K16/30 , C07K16/3053 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/66
摘要： The present invention relates to bispecific antibodies that specifically bind a T-cell activating antigen and a Tumor Antigen (TA), comprising a first Fab fragment and a second Fab fragment, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and wherein the bispecific antibody does not comprise a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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6.发明授权Multispecific antibodies comprising full length antibodies and single chain fab fragments 有权包含全长抗体和单链Fab片段的多特异性抗体公开(公告)号：US09382323B2
公开(公告)日：2016-07-05
申请号：US12750748
申请日：2010-03-31
申请人： Ulrich Brinkmann , Peter Bruenker , Rebecca Croasdale , Christian Klein , Erhard Kopetzki , Ekkehard Moessner , Joerg Thomas Regula , Juergen Michael Schanzer , Jan Olaf Stracke , Pablo Umana
发明人： Ulrich Brinkmann , Peter Bruenker , Rebecca Croasdale , Christian Klein , Erhard Kopetzki , Ekkehard Moessner , Joerg Thomas Regula , Juergen Michael Schanzer , Jan Olaf Stracke , Pablo Umana
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/00 , C07K16/468 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2319/00
摘要： The present invention relates to multispecific, especially bispecific antibodies comprising full length antibodies and single chain Fab fragments, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及包含全长抗体和单链Fab片段的多特异性，特别是双特异性抗体，其制备方法，含有该抗体的药物组合物及其用途。
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公开(公告)号：US20120244112A1
公开(公告)日：2012-09-27
申请号：US13367843
申请日：2012-02-07
申请人： Oliver Ast , Peter Bruenker , Anne Freimoser-Grundschober , Sylvia Herter , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
发明人： Oliver Ast , Peter Bruenker , Anne Freimoser-Grundschober , Sylvia Herter , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
CPC分类号： C07K16/40 , A61K38/2013 , A61K47/6813 , A61K47/6849 , A61K47/6871 , A61K47/6891 , A61K2039/505 , C07K14/55 , C07K16/30 , C07K2319/00
摘要： The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
摘要翻译： 本发明一般涉及对IL-2受体的α亚基表现出降低的亲和力的突变白细胞介素-2多肽，用作免疫治疗剂。 此外，本发明涉及包含所述突变型IL-2多肽，编码突变型IL-2多肽或免疫缀合物的多核苷酸分子以及包含该多核苷酸分子的载体和宿主细胞的免疫缀合物。 本发明还涉及用于产生突变型IL-2多肽或免疫缀合物的方法，包含其的药物组合物及其用途。
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公开(公告)号：US09447159B2
公开(公告)日：2016-09-20
申请号：US13457039
申请日：2012-04-26
申请人： Oliver Ast , Peter Bruenker , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Pablo Umana
发明人： Oliver Ast , Peter Bruenker , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Pablo Umana
IPC分类号： C07K16/46 , C07K14/54 , C07K14/55 , A61K47/48 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/40 , A61K39/44 , C12N15/13 , C12N15/63 , C12N5/10 , C12P21/00
CPC分类号： C07K16/40 , A61K38/2013 , A61K39/395 , A61K47/6813 , A61K47/6843 , A61K47/6849 , A61K47/6851 , A61K47/6853 , A61K2039/505 , C07K14/52 , C07K14/5434 , C07K14/55 , C07K16/18 , C07K16/283 , C07K16/2866 , C07K16/30 , C07K16/3007 , C07K16/46 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/55 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/92 , C07K2319/00 , C07K2319/30 , C07K2319/33 , C07K2319/74
摘要： The present invention generally relates to antigen-specific immunoconjugates for selectively delivering effector moieties that influence cellular activity. More specifically, the invention provides novel immunoconjugates comprising a first antigen binding moiety, an Fc domain and a single effector moiety. In addition, the present invention relates to polynucleotides encoding such immunoconjugates, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the immunoconjugates of the invention, and to methods of using these immunoconjugates in the treatment of disease.
摘要翻译： 本发明一般涉及用于选择性递送影响细胞活性的效应部分的抗原特异性免疫偶联物。 更具体地，本发明提供了包含第一抗原结合部分，Fc结构域和单个效应子部分的新型免疫偶联物。 此外，本发明涉及编码这种免疫缀合物的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。 本发明还涉及本发明的免疫缀合物的制备方法，以及使用这些免疫缀合物治疗疾病的方法。
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公开(公告)号：US09266938B2
公开(公告)日：2016-02-23
申请号：US13367843
申请日：2012-02-07
申请人： Oliver Ast , Peter Bruenker , Anne Freimoser-Grundschober , Sylvia Herter , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valerla G. Nicolini , Pablo Umana
发明人： Oliver Ast , Peter Bruenker , Anne Freimoser-Grundschober , Sylvia Herter , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valerla G. Nicolini , Pablo Umana
CPC分类号： C07K16/40 , A61K38/2013 , A61K47/6813 , A61K47/6849 , A61K47/6871 , A61K47/6891 , A61K2039/505 , C07K14/55 , C07K16/30 , C07K2319/00
摘要： The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
摘要翻译： 本发明一般涉及对IL-2受体的α亚基表现出降低的亲和力的突变白细胞介素-2多肽，用作免疫治疗剂。 此外，本发明涉及包含所述突变型IL-2多肽，编码突变型IL-2多肽或免疫缀合物的多核苷酸分子以及包含该多核苷酸分子的载体和宿主细胞的免疫缀合物。 本发明还涉及用于产生突变型IL-2多肽或免疫缀合物的方法，包含其的药物组合物及其用途。
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公开(公告)号：US20120276125A1
公开(公告)日：2012-11-01
申请号：US13457039
申请日：2012-04-26
申请人： Oliver Ast , Peter Bruenker , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Pablo Umana
发明人： Oliver Ast , Peter Bruenker , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Pablo Umana
IPC分类号： C07K16/46 , C12N15/13 , A61P37/04 , C12N5/10 , C12P21/00 , A61K39/44 , C07K14/55 , C12N15/63
CPC分类号： C07K16/40 , A61K38/2013 , A61K39/395 , A61K47/6813 , A61K47/6843 , A61K47/6849 , A61K47/6851 , A61K47/6853 , A61K2039/505 , C07K14/52 , C07K14/5434 , C07K14/55 , C07K16/18 , C07K16/283 , C07K16/2866 , C07K16/30 , C07K16/3007 , C07K16/46 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/55 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/92 , C07K2319/00 , C07K2319/30 , C07K2319/33 , C07K2319/74
摘要： The present invention generally relates to antigen-specific immunoconjugates for selectively delivering effector moieties that influence cellular activity. More specifically, the invention provides novel immunoconjugates comprising a first antigen binding moiety, an Fc domain and a single effector moiety. In addition, the present invention relates to polynucleotides encoding such immunoconjugates, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the immunoconjugates of the invention, and to methods of using these immunoconjugates in the treatment of disease.
摘要翻译： 本发明一般涉及用于选择性递送影响细胞活性的效应部分的抗原特异性免疫偶联物。 更具体地，本发明提供了包含第一抗原结合部分，Fc结构域和单个效应子部分的新型免疫偶联物。 此外，本发明涉及编码这种免疫缀合物的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。 本发明还涉及本发明的免疫缀合物的制备方法，以及使用这些免疫缀合物治疗疾病的方法。
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