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1.发明授权Multispecific antibodies comprising full length antibodies and single chain fab fragments 有权包含全长抗体和单链Fab片段的多特异性抗体公开(公告)号：US09382323B2
公开(公告)日：2016-07-05
申请号：US12750748
申请日：2010-03-31
申请人： Ulrich Brinkmann , Peter Bruenker , Rebecca Croasdale , Christian Klein , Erhard Kopetzki , Ekkehard Moessner , Joerg Thomas Regula , Juergen Michael Schanzer , Jan Olaf Stracke , Pablo Umana
发明人： Ulrich Brinkmann , Peter Bruenker , Rebecca Croasdale , Christian Klein , Erhard Kopetzki , Ekkehard Moessner , Joerg Thomas Regula , Juergen Michael Schanzer , Jan Olaf Stracke , Pablo Umana
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/00 , C07K16/468 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2319/00
摘要： The present invention relates to multispecific, especially bispecific antibodies comprising full length antibodies and single chain Fab fragments, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及包含全长抗体和单链Fab片段的多特异性，特别是双特异性抗体，其制备方法，含有该抗体的药物组合物及其用途。
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公开(公告)号：US10106600B2
公开(公告)日：2018-10-23
申请号：US13070582
申请日：2011-03-24
申请人： Ulrich Brinkmann , Rebecca Croasdale , Harald Duerr , Christian Klein , Erhard Kopetzki , Wilma Lau , Joerg Thomas Regula , Juergen Michael Schanzer , Pablo Umana , Katharina Wartha
发明人： Ulrich Brinkmann , Rebecca Croasdale , Harald Duerr , Christian Klein , Erhard Kopetzki , Wilma Lau , Joerg Thomas Regula , Juergen Michael Schanzer , Pablo Umana , Katharina Wartha
摘要： The present invention relates to bispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US20100256340A1
公开(公告)日：2010-10-07
申请号：US12752216
申请日：2010-04-01
申请人： Ulrich Brinkmann , Rebecca Croasdale , Eike Hoffmann , Christian Klein , Ekkehard Moessner , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
发明人： Ulrich Brinkmann , Rebecca Croasdale , Eike Hoffmann , Christian Klein , Ekkehard Moessner , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
CPC分类号： C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及三价，双特异性抗体，其制备方法，含有抗体的药物组合物及其用途。
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公开(公告)号：US09890204B2
公开(公告)日：2018-02-13
申请号：US13568224
申请日：2012-08-07
申请人： Ulrich Brinkmann , Rebecca Croasdale , Eike Hoffmann , Christian Klein , Ekkehard Moessner , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
发明人： Ulrich Brinkmann , Rebecca Croasdale , Eike Hoffmann , Christian Klein , Ekkehard Moessner , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
CPC分类号： C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
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公开(公告)号：US20130022601A1
公开(公告)日：2013-01-24
申请号：US13568224
申请日：2012-08-07
申请人： Ulrich Brinkmann , Rebecca Croasdale , Eike Hoffmann , Christian Klein , Ekkehard Moessner , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
发明人： Ulrich Brinkmann , Rebecca Croasdale , Eike Hoffmann , Christian Klein , Ekkehard Moessner , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
IPC分类号： C07K16/46 , A61P35/00 , C12N15/62 , A61K39/395
CPC分类号： C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及三价，双特异性抗体，其制备方法，含有抗体的药物组合物及其用途。
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公开(公告)号：US20100256339A1
公开(公告)日：2010-10-07
申请号：US12752196
申请日：2010-04-01
申请人： Birgit Bossenmaier , Ulrich Brinkmann , Wilma Dormeyer , Eike Hoffmann , Christian Klein , Gerhard Niederfellner , Juergen Michael Schanzer , Jan Olaf Stracke , Claudio Sustmann , Pablo Umana
发明人： Birgit Bossenmaier , Ulrich Brinkmann , Wilma Dormeyer , Eike Hoffmann , Christian Klein , Gerhard Niederfellner , Juergen Michael Schanzer , Jan Olaf Stracke , Claudio Sustmann , Pablo Umana
CPC分类号： C07K16/468 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2319/00
摘要： The present invention relates to bispecific antibodies against human ErbB-3 and against human c-Met, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人ErbB-3和针对人c-Met的双特异性抗体，其制备方法，含有该抗体的药物组合物及其用途。
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公开(公告)号：US20120149879A1
公开(公告)日：2012-06-14
申请号：US13330724
申请日：2011-12-20
申请人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Christian Gerdes , Eike Hoffmann , Christian Klein , Klaus-Peter Kuenkele , Wolfgang Schaefer , Jan Olaf Stracke , Pablo Umana
发明人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Christian Gerdes , Eike Hoffmann , Christian Klein , Klaus-Peter Kuenkele , Wolfgang Schaefer , Jan Olaf Stracke , Pablo Umana
IPC分类号： C07K16/46
CPC分类号： C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to bispecific antibodies against EGFR and against IGF-1R, methods for their production, pharmaceutical compositions containing said antibodies, and methods of treatment using the antibodies.
摘要翻译： 本发明涉及针对EGFR和针对IGF-1R的双特异性抗体，其制备方法，含有所述抗体的药物组合物和使用该抗体的治疗方法。
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公开(公告)号：US20100081796A1
公开(公告)日：2010-04-01
申请号：US12565786
申请日：2009-09-24
申请人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Christian Gerdes , Eike Hoffmann , Christian Klein , Klaus-Peter Kuenkele , Wolfgang Schaefer , Jan Olaf Stracke , Pablo Umana
发明人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Christian Gerdes , Eike Hoffmann , Christian Klein , Klaus-Peter Kuenkele , Wolfgang Schaefer , Jan Olaf Stracke , Pablo Umana
IPC分类号： C07K16/18
CPC分类号： C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to bispecific antibodies against EGFR and against IGF-1R, methods for their production, pharmaceutical compositions containing said antibodies, and methods of treatment using the antibodies.
摘要翻译： 本发明涉及针对EGFR和针对IGF-1R的双特异性抗体，其制备方法，含有所述抗体的药物组合物和使用该抗体的治疗方法。
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公开(公告)号：US20100254988A1
公开(公告)日：2010-10-07
申请号：US12753141
申请日：2010-04-02
申请人： Birgit Bossenmaier , Ulrich Brinkmann , Christian Klein , Gerhard Niederfellner , Wolfgang Schaefer , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
发明人： Birgit Bossenmaier , Ulrich Brinkmann , Christian Klein , Gerhard Niederfellner , Wolfgang Schaefer , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04 , A61P35/00
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00
摘要： The present invention relates to bispecific antibodies against human ErbB-2 and against human c-Met, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人ErbB-2和针对人c-Met的双特异性抗体，其制备方法，含有抗体的药物组合物及其用途。
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公开(公告)号：US20120244112A1
公开(公告)日：2012-09-27
申请号：US13367843
申请日：2012-02-07
申请人： Oliver Ast , Peter Bruenker , Anne Freimoser-Grundschober , Sylvia Herter , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
发明人： Oliver Ast , Peter Bruenker , Anne Freimoser-Grundschober , Sylvia Herter , Thomas U. Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Valeria G. Nicolini , Pablo Umana
CPC分类号： C07K16/40 , A61K38/2013 , A61K47/6813 , A61K47/6849 , A61K47/6871 , A61K47/6891 , A61K2039/505 , C07K14/55 , C07K16/30 , C07K2319/00
摘要： The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
摘要翻译： 本发明一般涉及对IL-2受体的α亚基表现出降低的亲和力的突变白细胞介素-2多肽，用作免疫治疗剂。 此外，本发明涉及包含所述突变型IL-2多肽，编码突变型IL-2多肽或免疫缀合物的多核苷酸分子以及包含该多核苷酸分子的载体和宿主细胞的免疫缀合物。 本发明还涉及用于产生突变型IL-2多肽或免疫缀合物的方法，包含其的药物组合物及其用途。
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