公开(公告)号：US4115555A

公开(公告)日：1978-09-19

申请号：US812886

申请日：1977-07-05

申请人： Peter C. Wade ,  Berthold Richard Vogt

发明人： Peter C. Wade ,  Berthold Richard Vogt

IPC分类号： C07D221/14 ,  C07H19/048 ,  A61K31/70

CPC分类号： C07D221/14 ,  C07H19/048

摘要： Compounds of the following formula ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, and trifluoromethyl, and R is selected from a triacetyl substituted pentose, pentose, a tetraacetyl substituted hexose, hexose, a hydroxy substituted cycloalkyl of 5 to 7 carbons, ##STR2## wherein n is 1 or 2 ad R.sup.3 is hydrogen, an alkali metal or alkaline earth metal ion; are disclosed. These compounds possess useful anti-inflammatory activity.

摘要翻译： 下式的化合物其中R 1和R 2独立地选自氢，卤素，低级烷基，低级烷氧基，低级烷硫基，硝基，氰基和三氟甲基，R选自三乙酰基取代的戊糖，戊糖，四乙酰 取代的己糖，己糖，5至7个碳的羟基取代的环烷基，其中n为1或2，R 3为氢，碱金属或碱土金属离子; 被披露。 这些化合物具有有用的抗炎活性。

公开(公告)号：US4070465A

公开(公告)日：1978-01-24

申请号：US699723

申请日：1976-06-24

申请人： Peter C. Wade ,  Berthold Richard Vogt

发明人： Peter C. Wade ,  Berthold Richard Vogt

IPC分类号： C07D221/14 ,  A61K31/495 ,  C07D401/06

CPC分类号： C07D221/14

摘要： Compounds of the following formula and their acid addition salts ##STR1## Z is ##STR2## A is straight or branched chain alkylene of 2 to 6 carbons; B is straight chain alkylene of 2 to 4 carbons; X is straight or branched chain alkyl of 1 to 8 carbons, phenyl, benzyl, phenethyl, substituted phenyl, substituted benzyl, or substituted phenethyl, R.sub.1 and R.sub.2 are located at the 7 or 8 and 5 or 6 position respectively and are independently selected from the group consisting of hydrogen, straight or branched chain alkyl of 1 to 4 carbons, straight or branched chain alkoxy of 1 to 4 carbons, Cl, Br, F, amino, nitro, CF.sub.3, and cyano; are disclosed. These compounds possess antiprotozoal activity.

摘要翻译： 下式的化合物及其酸加成盐：A是2至6个碳的直链或支链亚烷基; B是2至4个碳的直链亚烷基; X是1至8个碳的直链或支链烷基，苯基，苄基，苯乙基，取代的苯基，取代的苄基或取代的苯乙基，R1和R2分别位于7或8和5或6位，并且独立地选自 由氢，1至4个碳的直链或支链烷基，1至4个碳的直链或支链烷氧基，Cl，Br，F，氨基，硝基，CF 3和氰基组成的组; 被披露。 这些化合物具有抗原虫活性。

公开(公告)号：US4051246A

公开(公告)日：1977-09-27

申请号：US727836

申请日：1976-09-29

申请人： Peter C. Wade ,  Berthold Richard Vogt

发明人： Peter C. Wade ,  Berthold Richard Vogt

IPC分类号： A61K31/47 ,  A61K31/473 ,  A61P29/00 ,  C07D221/14 ,  C07H19/048 ,  C07D405/04

CPC分类号： C07D221/14 ,  C07H19/048

摘要： Compounds of the following formula ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, and trifluoromethyl, and R is selected from a triacetyl substituted pentose, pentose, a tetraacetyl substituted hexose, hexose, a hydroxy substituted cycloalkyl of 5 to 7 carbons, ##STR2## wherein n is 1 or 2 and R.sup.3 is hydrogen, an alkali metal or alkaline earth metal ion; are disclosed. These compounds possess useful anti-inflammatory activity.

公开(公告)号：US3959286A

公开(公告)日：1976-05-25

申请号：US538977

申请日：1975-01-06

申请人： Peter C. Wade ,  Berthold Richard Vogt

发明人： Peter C. Wade ,  Berthold Richard Vogt

IPC分类号： C07D221/14 ,  C07D401/06

CPC分类号： C07D221/14 ,  C07D401/06

摘要： Compounds of the following formula and their acid addition salts ##SPC1##Wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; R.sup.3 is phenyl or substituted phenyl; and R is lower alkyl or cycloalkyl of 3 to 7 carbons are disclosed. These compounds exhibit antidepressant activity. In addition these compounds are useful as antiinflammatory agents.

摘要翻译： 下式的化合物及其酸加成盐，其中R1和R2独立地选自氢，卤素，低级烷基，低级烷氧基，低级烷硫基，硝基，氰基，氨基和三氟甲基; A是1至8个碳的直链或支链亚烷基; R3是苯基或取代的苯基; 并且R是3至7个碳的低级烷基或环烷基。 这些化合物显示抗抑郁活性。 此外，这些化合物可用作抗炎剂。

公开(公告)号：US4077958A

公开(公告)日：1978-03-07

申请号：US718225

申请日：1976-08-27

申请人： Peter C. Wade ,  Berthold Richard Vogt

发明人： Peter C. Wade ,  Berthold Richard Vogt

IPC分类号： A61K31/4427 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/451 ,  A61K31/495 ,  A61P25/24 ,  A61P25/26 ,  C07D211/12 ,  C07D221/14 ,  C07D401/06 ,  C07D401/14

CPC分类号： C07D221/14

摘要： Compounds of the following formula ##STR1## wherein R.sup.1 and R.sup.2 are selected from hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, trifluoromethyl, nitro, amino and cyano; Z is selected from ##STR2## R.sup.3 is selected from phenyl, phenyl-lower alkyl, substituted phenyl, and substituted phenyl-lower alkyl; R.sup.4 is selected from R.sup.3 and a 6-membered unsaturated substituted or unsubstituted heterocyclic ring selected from pyridine, diazine and triazine; and A is a straight or branched chain alkylene of 2 to 8 carbons are disclosed. These compounds exhibit antidepressant activity.

摘要翻译： 下式的化合物其中R 1和R 2选自氢，低级烷基，低级烷氧基，低级烷硫基，卤素，三氟甲基，硝基，氨基和氰基; Z选自 R3选自苯基，苯基 - 低级烷基，取代的苯基和取代的苯基 - 低级烷基; R4选自R3和选自吡啶，二嗪和三嗪的6元不饱和取代或未取代的杂环; 并且A是2至8个碳的直链或支链亚烷基。 这些化合物显示抗抑郁活性。

公开(公告)号：US4007191A

公开(公告)日：1977-02-08

申请号：US621939

申请日：1975-10-14

申请人： Peter C. Wade ,  Berthold Richard Vogt

发明人： Peter C. Wade ,  Berthold Richard Vogt

IPC分类号： A61K31/4427 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/451 ,  A61K31/495 ,  A61P25/24 ,  A61P25/26 ,  C07D211/12 ,  C07D221/14 ,  C07D401/06

CPC分类号： C07D221/14

摘要： Compounds of the following formula ##STR1## wherein R.sup.1 and R.sup.2 are selected from hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, trifluoromethyl, nitro, amino and cyano; Z is selected from ##STR2## R.sup.3 is selected from phenyl, phenyl-lower alkyl, substituted phenyl, and substituted phenyl-lower alkyl; R.sup.4 is selected from R.sup.3 and a 6-membered unsaturated substituted or unsubstituted heterocyclic ring selected from pyridine, diazine and triazine; and A is a straight or branched chain alkylene of 2 to 8 carbons are disclosed. These compounds exhibit antidepressant activity.

摘要翻译： 下式的化合物其中R 1和R 2选自氢，低级烷基，低级烷氧基，低级烷硫基，卤素，三氟甲基，硝基，氨基和氰基; Z选自 R3选自苯基，苯基 - 低级烷基，取代的苯基和取代的苯基 - 低级烷基; R4选自R3和选自吡啶，二嗪和三嗪的6元不饱和取代或未取代的杂环; 并且A是2至8个碳的直链或支链亚烷基。 这些化合物显示抗抑郁活性。

公开(公告)号：US3996363A

公开(公告)日：1976-12-07

申请号：US586678

申请日：1975-06-13

申请人： Peter C. Wade ,  Berthold Richard Vogt

发明人： Peter C. Wade ,  Berthold Richard Vogt

IPC分类号： C07D471/10 ,  A61K31/445 ,  A61K31/47 ,  A61P25/24 ,  A61P25/26 ,  A61P29/00 ,  C07D221/00 ,  C07D235/00 ,  C07D401/06 ,  C07D471/00 ,  C07D487/10 ,  A61K31/645

CPC分类号： C07D471/10

摘要： Compounds of the following formula and their acid addition salts ##STR1## wherein R.sup.1 and R.sup.2 are selected from hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, trifluoromethyl, amino, nitro and cyano; R.sup.3 is hydrogen, lower alkyl or lower alkenyl; R.sup.4 is hydrogen, halogen, or lower alkyl; and A is straight or branched chain alkylene are disclosed. These compounds exhibit antidepressant activity. In addition, these compounds are useful as antiinflammatory agents.

摘要翻译： 下式的化合物及其酸加成盐其中R 1和R 2选自氢，低级烷基，低级烷氧基，低级烷硫基，卤素，三氟甲基，氨基，硝基和氰基; R3是氢，低级烷基或低级烯基; R4是氢，卤素或低级烷基; 并且A是直链或支链亚烷基。 这些化合物显示抗抑郁活性。 此外，这些化合物可用作抗炎剂。

公开(公告)号：US3935227A

公开(公告)日：1976-01-27

申请号：US501411

申请日：1974-08-28

申请人： Peter C. Wade ,  Berthold Richard Vogt

发明人： Peter C. Wade ,  Berthold Richard Vogt

IPC分类号： C07D221/06 ,  C07D221/14 ,  C07D401/06

CPC分类号： C07D221/14 ,  C07D221/06 ,  C07D401/06

摘要： Compounds of the following formula and their acid addition salts ##SPC1##Wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; and Z is selected from ##SPC2##Wherein R.sup.3 is selected from phenyl, phenyl-lower alkyl, and substituted phenyl and phenyl-lower alkyl are disclosed. These compounds exhibit antidepressant and anti-anxiety activity. In addition these compounds are useful as anti-inflammatory agents.

摘要翻译： 下式的化合物及其酸加成盐，其中R1和R2独立地选自氢，卤素，低级烷基，低级烷氧基，低级烷硫基，硝基，氰基，氨基和三氟甲基; A是1至8个碳的直链或支链亚烷基; 并且Z选自其中R 3选自苯基，苯基 - 低级烷基和取代的苯基和苯基 - 低级烷基。 这些化合物显示抗抑郁和抗焦虑活性。 此外，这些化合物可用作抗炎剂。

公开(公告)号：US4062953A

公开(公告)日：1977-12-13

申请号：US699724

申请日：1976-06-24

申请人： Peter C. Wade ,  Berthold Richard Vogt

发明人： Peter C. Wade ,  Berthold Richard Vogt

IPC分类号： A61K31/47 ,  C07D401/06 ,  C07D401/08

CPC分类号： C07D401/06 ,  A61K31/47

摘要： Compounds of the following formula and their acid addition salts ##STR1## A is straight or branched chain alkylene of 2 to 6 carbons; R.sub.1 and R.sub.2 are located at the 7 or 8 and 5 or 6 position respectively and are independently selected from the group consisting of hydrogen, straight or branched chain alkyl of 1 to 4 carbons, straight or branched chain alkoxy of 1 to 4 carbons, Cl, Br, F, amino, nitro, cyano, and CF.sub.3 ; R.sub.3 and R.sub.4 are independently selected from the group consisting of hydrogen and straight or branched chain alkyl of 1 to 4 carbons; and n is 1, 2, or 3; m is 1 or 2; are disclosed. These compounds possess anti-protozoal activity.

摘要翻译： 下式的化合物及其酸加成盐A是2至6个碳的直链或支链亚烷基; R1和R2分别位于7或8和5或6位，并且独立地选自氢，1至4个碳的直链或支链烷基，1至4个碳的直链或支链烷氧基，Cl ，Br，F，氨基，硝基，氰基和CF 3; R 3和R 4独立地选自氢和1至4个碳的直链或支链烷基; n为1,2或3; m为1或2; 被披露。 这些化合物具有抗原生动物活性。

公开(公告)号：US4020064A

公开(公告)日：1977-04-26

申请号：US680315

申请日：1976-04-26

申请人： Peter C. Wade ,  Berthold Richard Vogt

发明人： Peter C. Wade ,  Berthold Richard Vogt

IPC分类号： C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  C07D413/02

CPC分类号： C07D401/06 ,  C07D403/06 ,  C07D413/06

摘要： Compounds of the following formula and their pharmaceutically acceptable salts ##STR1## wherein R.sub.1 and R.sub.4 are the same or different and are each a five or six membered N containing heterocycle attached at an available N atom; R.sub.2 is hydrogen, alkyl, trifluoromethyl, phenyl, benzyl, --(CH.sub.2).sub.n --R.sub.4 or --(CH.sub.2).sub.n --N(alkyl).sub.2 ; R.sub.3 is hydrogen, halogen, nitro, trifluoromethyl, alkyl, alkoxy, or alkylthio; and n is an integer from 1 to 4; are disclosed. These compounds are useful as anti-inflammatory agents.

摘要翻译： 下式的化合物及其药学上可接受的盐，其中R 1和R 4相同或不同，并且各自为在可用的N原子上连接的5或6元N的杂环; R 2是氢，烷基，三氟甲基，苯基，苄基， - （CH 2）n -R 4或 - （CH 2）n -N（烷基）2; R3是氢，卤素，硝基，三氟甲基，烷基，烷氧基或烷硫基; n为1〜4的整数。 被披露。 这些化合物可用作抗炎剂。