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    SYSTEMS AND METHODS FOR DETECTING THE PRESENCE OF A SELECTED VOLUME OF MATERIAL IN A SAMPLE PROCESSING DEVICE
    2.
    发明申请
    SYSTEMS AND METHODS FOR DETECTING THE PRESENCE OF A SELECTED VOLUME OF MATERIAL IN A SAMPLE PROCESSING DEVICE 有权
    用于检测样品处理装置中选择的材料体积的存在的系统和方法

    公开(公告)号：US20120293796A1

    公开(公告)日：2012-11-22

    申请号：US13474903

    申请日：2012-05-18

    申请人： Peter D. Ludowise ,  David A. Whitman ,  Kyle C. Armantrout ,  Maurice Exner ,  Lucien A.E. Jacky ,  Michelle Tabb

    发明人： Peter D. Ludowise ,  David A. Whitman ,  Kyle C. Armantrout ,  Maurice Exner ,  Lucien A.E. Jacky ,  Michelle Tabb

    IPC分类号： G01N21/01

    CPC分类号： C12Q1/686 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/0605 ,  B01L2300/087 ,  B01L2400/0409 ,  G01N21/6486 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/0441

    摘要： Systems and methods for processing sample processing devices. The system can include a sample processing device comprising a detection chamber, a motor configured to rotate the sample processing device about an axis of rotation, and an optical module operatively positioned relative to the sample processing device and configured to determine whether a selected volume of material is present in the detection chamber of the sample processing device. The method can include rotating the sample processing device about an axis of rotation, and determining whether a selected volume of material is present in the detection chamber, while rotating the sample processing device. In some embodiments, determining whether a selected volume of material is present can be performed by optically interrogating the detection chamber for an optical property of the material.

    摘要翻译： 用于处理样品处理装置的系统和方法。 该系统可以包括样品处理装置，该样品处理装置包括检测室，被配置为围绕旋转轴线旋转样品处理装置的马达和相对于样品处理装置可操作地定位的光学模块，并配置成确定所选择的材料体积 存在于样品处理装置的检测室中。 该方法可以包括围绕旋转轴旋转样品处理装置，并且在旋转样品处理装置的同时确定所选择的材料体积是否存在于检测室中。 在一些实施例中，确定所选择的材料体积是否存在可以通过光学询问该检测室以获得该材料的光学特性。

    Assay for Mycobacterium avium/intracellulare nucleic acid
    3.
    发明授权
    Assay for Mycobacterium avium/intracellulare nucleic acid 有权
    分析鸟分枝杆菌/胞内分枝杆菌核酸

    公开(公告)号：US08084212B2

    公开(公告)日：2011-12-27

    申请号：US12887403

    申请日：2010-09-21

    申请人： Edgar Ong ,  Maurice Exner

    发明人： Edgar Ong ,  Maurice Exner

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H19/34

    CPC分类号： C12Q1/689 ,  C12Q2600/16

    摘要： Disclosed is a method for determining the presence of Mycobacterium avium complex nucleic acids in a biological sample. In particular, the IS1245 gene of M. avium and the DT1 gene of M. intracellulare are detected, preferably following amplification. In addition, the method distinguishes between species of M. avium and M. intracellulare. Also described are oligonucleotides that can be used as primers to amplify target genes such as IS1245 and DT1 genes and as probes as well as kits containing the oligonucleotides.

    摘要翻译： 公开了一种用于确定生物样品中鸟分枝杆菌复合物核酸的存在的方法。 特别地，优选在扩增后检测鸟分枝杆菌的IS1245基因和胞内分枝杆菌的DT1基因。 此外，该方法区分了鸟分枝杆菌和胞内分枝杆菌的种类。 还描述了可用作引物扩增靶基因如IS1245和DT1基因以及作为探针的寡核苷酸以及含有寡核苷酸的试剂盒。

    Methods for detecting and typing herpes simplex virus
    4.
    发明申请
    Methods for detecting and typing herpes simplex virus 审中-公开
    检测和分类单纯疱疹病毒的方法

    公开(公告)号：US20070141559A1

    公开(公告)日：2007-06-21

    申请号：US11314202

    申请日：2005-12-20

    申请人： Maurice Exner

    发明人： Maurice Exner

    IPC分类号： C12Q1/70 ,  C12Q1/68

    CPC分类号： C12Q1/705

    摘要： Detailed herein are methods of detecting herpes simplex virus and differentiating between types 1 and 2 by simultaneous detection of type-specific gene sequences. In particular aspects, individuals infected with HSV-1 can be distinguished from those infected with HSV-2 by amplification and detection of the HSV-1 glycoprotein B gene or the HSV-2 UL-8 gene. Primers and probes for the differential detection of HSV-1 and HSV-2 are provided.

    摘要翻译： 本文详细描述了通过同时检测类型特异性基因序列来检测单纯疱疹病毒并区分类型1和2之间的方法。 在特定方面，通过HSV-1糖蛋白B基因或HSV-2 UL-8基因的扩增和检测可以将感染HSV-1的个体与感染HSV-2的个体区分开。 提供用于HSV-1和HSV-2的差异检测的引物和探针。

    Kits for detecting mycobacterium avium/intracellulare nucleic acid
    5.
    发明授权
    Kits for detecting mycobacterium avium/intracellulare nucleic acid 有权

    公开(公告)号：US09797018B2

    公开(公告)日：2017-10-24

    申请号：US13296046

    申请日：2011-11-14

    申请人： Edgar Ong ,  Maurice Exner

    发明人： Edgar Ong ,  Maurice Exner

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/689 ,  C12Q2600/16

    摘要： Disclosed is a method for determining the presence of Mycobacterium avium complex nucleic acids in a biological sample. In particular, the mig gene of M. avium and the DT1 gene of M. intracellulare are detected, preferably following amplification. In addition, the method distinguishes between species of M. avium and M. intracellulare. Also described are oligonucleotides that can be used as primers to amplify target genes such as mig and DT1 genes and as probes as well as kits containing the oligonucleotide.

    Detection of Mycobacterium tuberculosis complex nucleic acids
    7.
    发明授权
    Detection of Mycobacterium tuberculosis complex nucleic acids 有权
    检测结核分枝杆菌复合核酸

    公开(公告)号：US08263330B1

    公开(公告)日：2012-09-11

    申请号：US11075825

    申请日：2005-03-08

    申请人： Maurice Exner

    发明人： Maurice Exner

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/02

    CPC分类号： C12Q1/689

    摘要： Disclosed is a method for determining the presence of Mycobacterium tuberculosis complex nucleic acids in a test sample. In particular, regions of the IS6110 preferential locus (ipl) 3′-flanking region of the Mycobacterium tuberculosis complex genome are amplified and detected. In addition, oligonucleotides that can be used as primers to amplify the ipl 3′-flanking region and probe oligonucleotides are described.

    摘要翻译： 公开了一种用于确定测试样品中结核分枝杆菌复合核酸的存在的方法。 特别地，扩增和检测结核分枝杆菌复合物基因组的IS6110优先位点（ipl）3'-侧翼区域。 此外，描述了可用作引物以扩增ipl 3'侧翼区和探针寡核苷酸的寡核苷酸。

    METHODS FOR DETECTING NUCLEIC ACIDS USING MULTIPLE SIGNALS
    8.
    发明申请
    METHODS FOR DETECTING NUCLEIC ACIDS USING MULTIPLE SIGNALS 失效
    使用多个信号检测核酸的方法

    公开(公告)号：US20100291583A1

    公开(公告)日：2010-11-18

    申请号：US12845465

    申请日：2010-07-28

    申请人： Maurice Exner ,  Amy Rogers

    发明人： Maurice Exner ,  Amy Rogers

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6818 ,  C12Q2563/173 ,  C12Q2527/107

    摘要： Disclosed is are methods for identifying a nucleic acid in a sample. In one example, the method includes: (a) contacting the nucleic acid in the sample with an oligonucleotide that is specific for the nucleic acid in the sample and that is labeled with at least a first fluorescent dye; (b) contacting the nucleic acid in the sample with a second fluorescent dye that is different from the first fluorescent dye, such that the second fluorescent dye interacts with the nucleic acid; (c) amplifying the nucleic acid if present in the sample; and (d) detecting the nucleic acid if present in the sample by observing fluorescence from the first fluorescent dye after the oligonucleotide hybridizes to the amplified nucleic acid and determining the melting temperature of the amplified nucleic acid by measuring the fluorescence of the second fluorescent dye. The second fluorescent dye may include a fluorescent intercalating agent.

    摘要翻译： 公开了用于鉴定样品中核酸的方法。 在一个实例中，该方法包括：（a）使样品中的核酸与样品中核酸特异的寡核苷酸接触，并用至少第一荧光染料标记; （b）使样品中的核酸与不同于第一荧光染料的第二荧光染料接触，使得第二荧光染料与核酸相互作用; （c）如果存在于样品中则扩增核酸; 以及（d）通过在寡核苷酸与扩增的核酸杂交后通过观察来自第一荧光染料的荧光检测样品中的核酸，并通过测量第二荧光染料的荧光来测定扩增的核酸的解链温度。 第二荧光染料可以包括荧光嵌入剂。