摘要:
A radio communication system is provided wherein radio coverage building blocks are used to provide uniform radio coverage to rectilinear floor layouts of buildings. The building blocks are comprised of directional and omnidirectional antennas which are applied to rectangular and irregular layouts. Each building block is divided into multiple small zones and each zone is covered by an antenna. Each antenna in the building block is connected to the same base station through a low loss coupling matrix and all antennas transmit and receive simultaneously. The directional antennas are located near the boundary of the service area. An omnidirectional or directional antenna at the center of the zone may be used to fill the rest of the area.
摘要:
This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this invention typically comprise one or more AAV packaging genes, an AAV vector comprising a heterologous (i.e. non-AAV) transgene of interest, and a helper virus such as an adenovirus. The AAV vector preparations produced are generally replication incompetent but are capable of mediating delivery of a transgene of interest (such as a therapeutic gene) to any of a wide variety of tissues and cells. The AAV vector preparations produced according to this invention are also substantially free of helper virus as well as helper viral and cellular proteins and other contaminants. The invention described herein provides methods of producing rAAV particles by culturing producer cells under conditions, such as temperature and pH, that promote release of virus. Also provided is a quantitative, high-throughput assay useful in the assessment of viral infectivity and replication, as well as in the screening of agent that affect viral infectivity and/or replication.
摘要:
A method for producing recombinant proteins, preferably fusion proteins comprising an Fc portion of an immunoglobulin molecule, more preferably fusion proteins comprising an extracellular domain of a tumor necrosis factor receptor fused to the Fc portion of an immunoglobulin molecule, is disclosed. The method of the present invention allows a reduction of misfolding of the protein, thereby giving rise to a higher yield of the desired protein.
摘要:
Nucleic acid sequences which encode biologically active EMF, expression vectors which direct the expression of ETF, ETE polypeptides, antibodies which specffically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要:
Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要:
There is disclosed a mammalian epithelium-derived T-cell factor (EFT) polypeptide, derivatives thereof, DNA sequences, recombinant DNA molecules and transformed host cells that produce ETF polypeptides. More particularly, this invention provides isolated mammalian ETF polypeptides and derivatives thereof that regulate events in T-lymphocyte proliferation.
摘要:
Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要:
Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要:
Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要:
A communications stimulation system allows a user to perform a quantitative or subjective test of digital baseband devices over wireless channels using actual measured or modeled propagation data. The digital wireless communication simulation system is capable of simulating the transient nature of channels and radio hardware so that loss of synchronization can be included in the simulation. The simulator is a combination of computer software and hardware that computes a convolution, in the time domain, of a sequence of binary digits or data symbols (i.e., the data stream) with a computer model of a radio transmitter, a propagation channel or channels and a receiver. The transmitter typically comprises a coder, a pulse shaper, a modulator, and a spreader. The propagation channel or channels may include impulsive and average noise levels, co-channel interference and adjacent interference levels, fading and multipath propagation events, and non-linear channel and radio system effects. The receiver system typically comprises at least a filter bank, a demodulator, a despreader, a synchronizer, a detector, and a decoder. The data stream may either be random or applied by the user. The software computes the bit-by-bit sequence for replay at a later time. Once stored, the bit-by-bit error sequence can be clocked through a hardware data port and compared with an applied data stream in real time. The output of the hardware data port is a real time sequence of bits that has errors due to the bit-by-bit simulation computed earlier by the software.