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1.发明申请2-PYRIDONE DERIVATIVES FOR THE TREATMENT OF DISEASE OR CONDITION IN WHICH INHIBITION OF NEUTROPHIL ELASTASE ACTIVITY IS BENEFICIAL 失效用于治疗抑制中性粒细胞活化的疾病或病症的2-吡啶酮衍生物是有益的公开(公告)号：US20090131486A1
公开(公告)日：2009-05-21
申请号：US12299879
申请日：2007-05-07
申请人： Peter Hansen , Karolina Lawitz , Matti Lepisto , Hans Lonn , Asim Ray
发明人： Peter Hansen , Karolina Lawitz , Matti Lepisto , Hans Lonn , Asim Ray
IPC分类号： A61K31/44 , C07D213/78 , A61P11/08
CPC分类号： C07D401/04 , C07D413/04 , C07D417/04
摘要： The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译： 本发明提供下式的化合物其中R 1，R 3，R 4，R 5，R 6，R 14，X和W如说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。 这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。
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2.发明授权2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial 失效2-吡嗪酮衍生物用于治疗嗜中性粒细胞弹性蛋白酶活性抑制有益的疾病或病症公开(公告)号：US08410114B2
公开(公告)日：2013-04-02
申请号：US13344658
申请日：2012-01-06
申请人： Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lonn , Antonios Nikitidis , Asim Ray
发明人： Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lonn , Antonios Nikitidis , Asim Ray
IPC分类号： A61K31/4965
CPC分类号： C07D401/14 , C07D401/12 , C07D403/04 , C07D403/14
摘要： The invention provides compounds of formula wherein R1, R3, R4, R5, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译： 本发明提供下列结构的化合物，其中R 1，R 3，R 4，R 5，R 14，X和W如说明书中所定义，并且其旋光异构体，外消旋体和互变异构体及其药学上可接受的盐; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。 这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。
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3.发明申请2-PYRAZINONE DERIVATIVES FOR THE TREATMENT OF DISEASE OR CONDITION IN WHICH INHIBITION OF NEUTROPHIL ELASTASE ACTIVITY IS BENEFICIAL 失效用于治疗抑制中性粒细胞活化的疾病或病症的2-吡嗪酮衍生物是有益的公开(公告)号：US20120108610A1
公开(公告)日：2012-05-03
申请号：US13344658
申请日：2012-01-06
申请人： Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lonn , Antonios Nikitidis , Asim Ray
发明人： Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lonn , Antonios Nikitidis , Asim Ray
IPC分类号： A61K31/497 , C07D401/14 , C07D401/04 , A61P29/00 , A61P11/00 , A61P1/00 , A61P17/06 , A61P19/02 , A61P9/10 , A61P17/02 , A61P1/04 , C07D403/04 , A61P11/06
CPC分类号： C07D401/14 , C07D401/12 , C07D403/04 , C07D403/14
摘要： The invention provides compounds of formula wherein R1, R3, R4, R5, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译： 本发明提供下列结构的化合物，其中R 1，R 3，R 4，R 5，R 14，X和W如说明书中所定义，并且其旋光异构体，外消旋物和互变异构体及其药学上可接受的盐; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。 这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。
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公开(公告)号：US20090131483A1
公开(公告)日：2009-05-21
申请号：US11908746
申请日：2006-03-14
申请人： Peter Hansen , Karolina Lawitz , Hans Lonn , Antonios Nikitidis
发明人： Peter Hansen , Karolina Lawitz , Hans Lonn , Antonios Nikitidis
IPC分类号： A61K31/4439 , C07D413/14 , C07D413/02 , A61P29/00 , A61P11/00 , A61K31/44 , C07D213/81
CPC分类号： C07D213/82 , C07D413/12 , C07D413/14
摘要： The invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5 and X are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译： 本发明提供式（I）化合物，其中R 1，R 2，R 3，R 4，R 5和X如说明书中所定义，并且其旋光异构体，外消旋体和互变异构体及其药学上可接受的盐; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。 这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。
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5.发明授权2-pyridone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial 失效用于治疗中性粒细胞弹性蛋白酶活性抑制有益的疾病或病症的2-吡啶酮衍生物公开(公告)号：US07998984B2
公开(公告)日：2011-08-16
申请号：US12299879
申请日：2007-05-07
申请人： Peter Hansen , Karolina Lawitz , Matti Lepistö , Hans Lönn , Asim Ray
发明人： Peter Hansen , Karolina Lawitz , Matti Lepistö , Hans Lönn , Asim Ray
IPC分类号： A61K31/44 , A61K31/47 , C07D413/00 , C07D401/00
CPC分类号： C07D401/04 , C07D413/04 , C07D417/04
摘要： The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译： 本发明提供下式的化合物其中R 1，R 3，R 4，R 5，R 6，R 14，X和W如说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。 这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。
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6.发明申请2-PYRAZINONE DERIVATIVES FOR THE TREATMENT OF DISEASE OR CONDITION IN WHICH INHIBITION OF NEUTROPHIL ELASTASE ACTIVITY IS BENEFICIAL 失效用于治疗抑制中性粒细胞活化的疾病或病症的2-吡嗪酮衍生物是有益的公开(公告)号：US20090209555A1
公开(公告)日：2009-08-20
申请号：US12299878
申请日：2007-05-07
申请人： Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lönn , Antonios Nikitidis , Asim Ray
发明人： Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lönn , Antonios Nikitidis , Asim Ray
IPC分类号： A61K31/497 , C07D403/02 , C07D403/14 , A61P11/00 , A61P35/00 , A61P1/00 , A61P29/00
CPC分类号： C07D401/14 , C07D401/12 , C07D403/04 , C07D403/14
摘要： The invention provides compounds of formula wherein R1, R3, R4, R5, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译： 本发明提供下列结构的化合物，其中R 1，R 3，R 4，R 5，R 14，X和W如说明书中所定义，并且其旋光异构体，外消旋体和互变异构体及其药学上可接受的盐; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。 这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。
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7.发明授权2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial 失效2-吡嗪酮衍生物用于治疗嗜中性粒细胞弹性蛋白酶活性抑制有益的疾病或病症公开(公告)号：US08114881B2
公开(公告)日：2012-02-14
申请号：US12299878
申请日：2007-05-07
申请人： Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lönn , Antonios Nikitidis , Asim Ray
发明人： Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lönn , Antonios Nikitidis , Asim Ray
IPC分类号： A61K31/4965
CPC分类号： C07D401/14 , C07D401/12 , C07D403/04 , C07D403/14
摘要： The invention provides compounds of formula wherein R1, R3, R4, R5, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译： 本发明提供下列结构的化合物，其中R 1，R 3，R 4，R 5，R 14，X和W如说明书中所定义，并且其旋光异构体，外消旋体和互变异构体及其药学上可接受的盐; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。 这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。
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8.发明申请2-Pyridone derivatives as neutrophil elastase inhibitors and their use 审中-公开2-吡啶酮衍生物作为嗜中性粒细胞弹性蛋白酶抑制剂及其应用公开(公告)号：US20070043036A1
公开(公告)日：2007-02-22
申请号：US10572640
申请日：2004-09-15
申请人： Peter Hansen , Karolina Lawitz , Hans Lonn , Antonios Nikitidis
发明人： Peter Hansen , Karolina Lawitz , Hans Lonn , Antonios Nikitidis
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/497 , A61K31/496 , A61K31/4965 , A61K31/4439 , A61K31/4415 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D213/82 , C07D213/85 , C07D401/04
摘要： There are provided novel compounds of formula (I), wherein R1, R2, R4, R5, G1, G2, L, Y and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.
摘要翻译： 提供了新的式（I）化合物，其中R 1，R 2，R 4，R 5， G 1，G 2，L 2，Y 2和n如本说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的组合物及其在治疗中的用途。 这些化合物是嗜中性粒细胞弹性蛋白酶抑制剂。
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公开(公告)号：US20090286835A1
公开(公告)日：2009-11-19
申请号：US12245275
申请日：2008-10-03
申请人： Hakan BLADH , Frank Burkamp , Balint Gabos , Peter Hansen , Svetlana Ivanova , Karolina Lawitz
发明人： Hakan BLADH , Frank Burkamp , Balint Gabos , Peter Hansen , Svetlana Ivanova , Karolina Lawitz
IPC分类号： A61K31/4439 , C07D277/20 , C07D285/06 , C07D231/54 , C07D249/04 , C07D261/18 , C07D401/14 , A61P11/06 , A61K31/427 , A61K31/425 , A61K31/416 , A61K31/4192 , A61K31/42
CPC分类号： C07J71/0047
摘要： The present invention provides compounds of formula (I) wherein n, p, R1, R2, X1, X2, X3, X4, X5, R3a, R3b, R4, R5 and R6 are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）化合物，其中n，p，R1，R2，X1，X2，X3，X4，X5，R3a，R3b，R4，R5和R6如说明书中所定义， ，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US20120178726A1
公开(公告)日：2012-07-12
申请号：US13417626
申请日：2012-03-12
申请人： Håkan Bladh , Frank Burkamp , Balint Gabos , Peter Hansen , Svetlana Ivanova , Karolina Lawitz
发明人： Håkan Bladh , Frank Burkamp , Balint Gabos , Peter Hansen , Svetlana Ivanova , Karolina Lawitz
CPC分类号： C07J71/0047
摘要： The present invention provides compounds of formula (I) wherein n, p, R1, R2, X1, X2, X3, X4, X5, R3a, R3b, R4, R5 and R6 are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）化合物，其中n，p，R1，R2，X1，X2，X3，X4，X5，R3a，R3b，R4，R5和R6如说明书中所定义， ，含有它们的药物组合物及其在治疗中的用途。
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