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公开(公告)号：US20060019301A1
公开(公告)日：2006-01-26
申请号：US11186641
申请日：2005-07-20
申请人： Peter Hansen , Mads Bjoernvad , Joel Cherry , Aubrey Jones , Amanda Fischer
发明人： Peter Hansen , Mads Bjoernvad , Joel Cherry , Aubrey Jones , Amanda Fischer
CPC分类号： C40B50/06 , C12N15/102 , C12N15/1082 , C40B40/08
摘要： The present invention relates to methods of producing mutants of a polynucleotide and to mutant polynucleotides and artificial variants encoded by the mutant polynucleotides.
摘要翻译： 本发明涉及产生多核苷酸的突变体的方法和由突变体多核苷酸编码的突变体多核苷酸和人造变体的方法。
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公开(公告)号：US08383385B2
公开(公告)日：2013-02-26
申请号：US13009524
申请日：2011-01-19
申请人： Sarah Teter , Connie Ward , Joel Cherry , Aubrey Jones , Paul Harris , Jung Yi
发明人： Sarah Teter , Connie Ward , Joel Cherry , Aubrey Jones , Paul Harris , Jung Yi
CPC分类号： C12N9/2437 , C11D3/38645 , C12N9/2434 , C12N9/2445 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01021 , C12Y302/01091 , C12Y302/01176
摘要： The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.
摘要翻译： 本发明涉及母体糖苷水解酶的变体，其包含在对应于位置21,94,157,205,206,247,337,350,373,383,438,455,467的一个或多个位置的取代，和 486，SEQ ID NO：2的氨基酸1至513，并且任选地还包含在对应于位置8,22,41,49,57,113,193,196,226,227,246,29的一个或多个位置的取代， SEQ ID NO：2的氨基酸1至513的251,255,259,301,356,371,411和462在对应于位置8,22,41,49,57,113， SEQ ID NO：2的氨基酸1至513的193,196,226,227,246,251,255,259,301,356,371,411和462，其中所述变体具有糖苷水解酶活性。 本发明还涉及编码变体糖苷水解酶的核苷酸序列以及包含核苷酸序列的核酸构建体，载体和宿主细胞。
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公开(公告)号：US07932073B2
公开(公告)日：2011-04-26
申请号：US11891249
申请日：2007-08-08
申请人： Sarah Teter , Connie Ward , Joel Cherry , Aubrey Jones , Paul Harris , Jung Yi
发明人： Sarah Teter , Connie Ward , Joel Cherry , Aubrey Jones , Paul Harris , Jung Yi
CPC分类号： C12N9/2437 , C11D3/38645 , C12N9/2434 , C12N9/2445 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01021 , C12Y302/01091 , C12Y302/01176
摘要： The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.
摘要翻译： 本发明涉及母体糖苷水解酶的变体，其包含在对应于位置21,94,157,205,206,247,337,350,373,383,438,455,467的一个或多个位置的取代，和 486，SEQ ID NO：2的氨基酸1至513，并且任选地还包含在对应于位置8,22,41,49,57,113,193,196,226,227,246,29的一个或多个位置的取代， SEQ ID NO：2的氨基酸1至513的251,255,259,301,356,371,411和462在对应于位置8,22,41,49,57,113， SEQ ID NO：2的氨基酸1至513的193,196,226,227,246,251,255,259,301,356,371,411和462，其中所述变体具有糖苷水解酶活性。 本发明还涉及编码变体糖苷水解酶的核苷酸序列以及包含核苷酸序列的核酸构建体，载体和宿主细胞。
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公开(公告)号：US20050048619A1
公开(公告)日：2005-03-03
申请号：US10926223
申请日：2004-08-25
申请人： Sarah Teter , Joel Cherry , Connie Ward , Aubrey Jones , Paul Harris , Jung Yi
发明人： Sarah Teter , Joel Cherry , Connie Ward , Aubrey Jones , Paul Harris , Jung Yi
CPC分类号： C12N9/2437 , C11D3/38645 , C12N9/2434 , C12N9/2445 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01021 , C12Y302/01091 , C12Y302/01176 , Y02E50/16
摘要： The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.
摘要翻译： 本发明涉及母体糖苷水解酶的变体，其包含在对应于位置21,94,157,205,206,247,337,350,373,383,438,455,467的一个或多个位置的取代，和 486，SEQ ID NO：2的氨基酸1至513，并且任选地还包含在对应于位置8,22,41,49,57,113,193,196,226,227,246,29的一个或多个位置的取代， SEQ ID NO：2的氨基酸1至513的251,255,259,301,356,371,411和462在对应于位置8,22,41,49,57,113， SEQ ID NO：2的氨基酸1至513的193,196,226,227,246,251,255,259,301,356,371,411和462，其中所述变体具有糖苷水解酶活性。 本发明还涉及编码变体糖苷水解酶的核苷酸序列以及包含核苷酸序列的核酸构建体，载体和宿主细胞。
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公开(公告)号：US20110136167A1
公开(公告)日：2011-06-09
申请号：US13009524
申请日：2011-01-19
申请人： Sarah Teter , Joel Cherry , Connie Ward , Aubrey Jones , Paul Harris , Jung Yi
发明人： Sarah Teter , Joel Cherry , Connie Ward , Aubrey Jones , Paul Harris , Jung Yi
CPC分类号： C12N9/2437 , C11D3/38645 , C12N9/2434 , C12N9/2445 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01021 , C12Y302/01091 , C12Y302/01176
摘要： The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.
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公开(公告)号：US20080167214A1
公开(公告)日：2008-07-10
申请号：US11891249
申请日：2007-08-08
申请人： Sarah Teter , Joel Cherry , Connie Ward , Aubrey Jones , Paul Harris , Jung Yi
发明人： Sarah Teter , Joel Cherry , Connie Ward , Aubrey Jones , Paul Harris , Jung Yi
CPC分类号： C12N9/2437 , C11D3/38645 , C12N9/2434 , C12N9/2445 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01021 , C12Y302/01091 , C12Y302/01176
摘要： The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.
摘要翻译： 本发明涉及母体糖苷水解酶的变体，其包含在对应于位置21,94,157,205,206,247,337,350,373,383,438,455,467的一个或多个位置的取代，和 486，SEQ ID NO：2的氨基酸1至513，并且任选地还包含在对应于位置8,22,41,49,57,113,193,196,226,227,246,29的一个或多个位置的取代， SEQ ID NO：2的氨基酸1至513的251,255,259,301,356,371,411和462在对应于位置8,22,41,49,57,113， SEQ ID NO：2的氨基酸1至513的193,196,226,227,246,251,255,259,301,356,371,411和462，其中所述变体具有糖苷水解酶活性。 本发明还涉及编码变体糖苷水解酶的核苷酸序列以及包含核苷酸序列的核酸构建体，载体和宿主细胞。
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公开(公告)号：US20110159570A1
公开(公告)日：2011-06-30
申请号：US13010219
申请日：2011-01-20
IPC分类号： C12N9/28
CPC分类号： C12N9/2417 , A21D2/26 , A21D8/042
摘要： The inventors have modified the amino acid sequence of a maltogenic alpha-amylase to obtain variants with improved properties, based on the three-dimensional structure of the maltogenic alpha-amylase Novamyl. The variants have altered physicochemical properties, e.g. an altered pH optimum, improved thermostability, increased specific activity, an altered cleavage pattern or an increased ability to reduce retrogradation of starch or staling of bread.
摘要翻译： 基于麦芽糖α-淀粉酶Novamyl的三维结构，本发明人已经修饰了产麦芽糖α-淀粉酶的氨基酸序列以获得具有改进性质的变体。 这些变体具有改变的物理化学性质，例如 改变的pH最佳，改善的热稳定性，增加的比活性，改变的切割模式或增加降低淀粉退化或面包陈化的能力。
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公开(公告)号：US20070015677A1
公开(公告)日：2007-01-18
申请号：US10555484
申请日：2004-05-06
申请人： Stefan Minning , Jurgen Carsten Franz Knotzel , Niels Sorensen , Jon Ness , Mark Welch , Lorraine Giver , Joel Cherry , Torben Borchert , Jeremy Minshull
发明人： Stefan Minning , Jurgen Carsten Franz Knotzel , Niels Sorensen , Jon Ness , Mark Welch , Lorraine Giver , Joel Cherry , Torben Borchert , Jeremy Minshull
CPC分类号： C11D3/38636 , C11D3/38681 , C12N9/52 , Y02P20/582
摘要： Novel subtilases having an improved wash performance on egg stains. These subtilases are useful exhibiting excellent or improved wash performance on egg stains when used in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions.
摘要翻译： 具有改进的蛋渍洗涤性能的新型枯草芽孢杆菌。 当用于例如蛋白质时，这些脱水酶可用于在蛋渍上表现出优异或改善的洗涤性能。 清洁剂或洗涤剂组合物，例如衣物洗涤剂组合物和洗碟组合物，包括自动洗碗组合物。
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9.发明授权Haloperoxidases from Curvularia verruculosa and nucleic acids encoding same 失效来自曲霉疣孢菌的卤素过氧化物酶和编码相同的核酸
公开(公告)号：US5965418A
公开(公告)日：1999-10-12
申请号：US842799
申请日：1997-04-16
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/08 , C12N15/52 , C12N15/53 , C12N15/80 , C12P21/02 , C12R1/645 , C12N15/63
CPC分类号： C12N9/0065 , Y10S435/911
摘要： The present invention relates to Curvularia verruculosa haloperoxidases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the haloperoxidases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods for recombinant production of the haloperoxidase. The invention further relates to compositions comprising the haloperoxidases and methods of using the compositions for killing microbial cells or inhibiting growth of microbial cells.
摘要翻译： 本发明涉及疣状弧菌弧菌过氧化物酶和包含编码卤代过氧化物酶的核酸序列以及包含核酸序列的核酸构建体，载体和重组宿主细胞的分离的核酸片段。 本发明还涉及重组生产卤代过氧化物酶的方法。 本发明还涉及包含卤代过氧化物酶的组合物和使用该组合物杀死微生物细胞或抑制微生物细胞生长的方法。
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10.发明授权Processes for preparing a dough or a baked product using maltogenic alpha-amylase variants 有权使用产麦芽糖α-淀粉酶变体制备面团或烘焙产品的方法公开(公告)号：US08546099B2
公开(公告)日：2013-10-01
申请号：US13533055
申请日：2012-06-26
CPC分类号： C12N9/2417 , A21D2/26 , A21D8/042
摘要： The inventors have modified the amino acid sequence of a maltogenic alpha-amylase to obtain variants with improved properties, based on the three-dimensional structure of the maltogenic alpha-amylase Novamyl. The variants have altered physicochemical properties, e.g. an altered pH optimum, improved thermostability, increased specific activity, an altered cleavage pattern or an increased ability to reduce retrogradation of starch or staling of bread.
摘要翻译： 基于麦芽糖α-淀粉酶Novamyl的三维结构，本发明人已经修饰了产麦芽糖α-淀粉酶的氨基酸序列以获得具有改进性质的变体。 这些变体具有改变的物理化学性质，例如 改变的pH最佳，改善的热稳定性，增加的比活性，改变的切割模式或增加降低淀粉退化或面包陈化的能力。
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