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    DOMAIN-GRAFTED ANTIBODIES
    1.
    发明申请
    DOMAIN-GRAFTED ANTIBODIES 审中-公开
    DOMAIN-GRAFTED抗体

    公开(公告)号：US20090241202A1

    公开(公告)日：2009-09-24

    申请号：US12095822

    申请日：2006-12-14

    申请人： Peter Kufer ,  Tobias Raum ,  Petra Lutterbüse ,  Bernd Schlereth ,  Klaus Brischwein ,  Robert Hofmeister

    发明人： Peter Kufer ,  Tobias Raum ,  Petra Lutterbüse ,  Bernd Schlereth ,  Klaus Brischwein ,  Robert Hofmeister

    IPC分类号： A61K49/00 ,  C07K16/00 ,  C12N15/63 ,  C12N5/00 ,  C12P21/00

    CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/462 ,  C07K2317/732

    摘要： The present invention relates to antibodies. Specifically, the present invention relates to antibodies composed of novel combinations of inter-species antibody domains (“domain-grafted antibodies”). The present invention further relates to compositions comprising such domain-grafted antibodies, as well as methods for producing such domain-grafted antibodies. Finally, the present invention relates to methods of evaluating the in vivo biological effect of such domain-grafted antibodies as well as uses of such domain-grafted antibodies for cross-species evaluation of the in vivo activity antibodies intended for human therapy.

    摘要翻译： 本发明涉及抗体。 具体地，本发明涉及由物种间抗体结构域（“结构域接枝抗体”）的新型组合构成的抗体。 本发明还涉及包含这种结构域接枝抗体的组合物，以及生产这种结构域接枝抗体的方法。 最后，本发明涉及评价这种结构域接枝抗体的体内生物学效应的方法以及这种结构域接枝抗体用于物种评价用于人类治疗的体内活性抗体的用途。

    BIOLOGICAL MATERIALS RELATED TO HER3
    7.
    发明申请
    BIOLOGICAL MATERIALS RELATED TO HER3 有权
    与其相关的生物材料3

    公开(公告)号：US20130136748A1

    公开(公告)日：2013-05-30

    申请号：US13698992

    申请日：2011-05-20

    申请人： Christine Knuehl ,  Bjoern Hock ,  Robert Hofmeister ,  Gerald Beste ,  Hilde Adi Pierrette Revets ,  Frank Kamiel Delphina Verdonck ,  Sigrid Godelieve Victor Cornelis

    发明人： Christine Knuehl ,  Bjoern Hock ,  Robert Hofmeister ,  Gerald Beste ,  Hilde Adi Pierrette Revets ,  Frank Kamiel Delphina Verdonck ,  Sigrid Godelieve Victor Cornelis

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2863 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/18 ,  C07K16/32 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

    摘要： The present disclosure relates to amino acid sequences that are directed against (as defined herein) HER3, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences (also referred to herein as “amino acid sequences of the invention”, “compounds of the invention”, and “polypeptides of the invention”, respectively). The disclosure also relates to nucleic acids encoding such amino acid sequences and polypeptides (also referred to herein as “nucleic acids of the invention” or “nucleotide sequences of the invention”); to methods for 10 preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes, such as the prophylactic, therapeutic or diagnostic purposes mentioned herein.

    摘要翻译： 本公开涉及针对（如本文所定义）HER3以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽的氨基酸序列（也称为 在本文中分别为“本发明的氨基酸序列”，“本发明的化合物”和“本发明的多肽”）。 本公开还涉及编码这种氨基酸序列和多肽（本文中也称为“本发明的核酸”或“本发明的核苷酸序列”）的核酸; 涉及10种制备此类氨基酸序列和多肽的方法; 宿主表达或能够表达这种氨基酸序列或多肽的细胞; 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的，例如本文提及的预防，治疗或诊断目的。