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    Compounds for treating disorders of lipid metabolism and their preparation
    2.
    发明授权
    Compounds for treating disorders of lipid metabolism and their preparation 失效
    用于治疗脂质代谢紊乱及其制备的化合物

    公开(公告)号：US5773447A

    公开(公告)日：1998-06-30

    申请号：US874255

    申请日：1997-06-13

    申请人： Gerhard Rackur ,  Hans Georg Boger ,  Norbert Krass ,  Axel Hoffmann ,  Michael Leineweber

    发明人： Gerhard Rackur ,  Hans Georg Boger ,  Norbert Krass ,  Axel Hoffmann ,  Michael Leineweber

    IPC分类号： A61K31/505 ,  A61P3/06 ,  C07D403/04 ,  C07D403/14 ,  C07D239/02

    CPC分类号： C07D403/04 ,  C07D403/14

    摘要： The present invention relates to tertiary 4-amino-2-ureidopyrimidine-5-carboxamides of formula I: ##STR1## in which R.sup.1 is (C.sub.1 -C.sub.8)-alkyl wherein one or more H are replaced by F; R.sup.2 is selected from the group consisting of F, Cl, Br, H, --O--(C.sub.1 -C.sub.8)-alkyl and (C.sub.1 -C.sub.8)-alkyl, wherein one or more of the H of the alkyls can be replaced by F; R.sup.3 is selected from the group consisting of F, Cl, Br, H, --O--(C.sub.1 -C.sub.4)-alkyl and (C.sub.1 -C.sub.4)-alkyl, wherein one or more of the H of the alkyl can be replaced by F; R.sup.4 is CF.sub.3 or OCF.sub.3 ; and their physiologically tolerable salts. Process for preparing the compounds of formula I are also described. The compounds are suitable for the treatment of disorders of lipid metabolism.

    摘要翻译： 本发明涉及式I的叔-4-氨基-2-脲基嘧啶-5-甲酰胺：一个或多个H被F取代; R 2选自F，Cl，Br，H，-O-（C 1 -C 8） - 烷基和（C 1 -C 8） - 烷基，其中烷基的H中的一个或多个可以被F ; R 3选自F，Cl，Br，H，-O-（C 1 -C 4） - 烷基和（C 1 -C 4） - 烷基，其中烷基的H中的一个或多个可以被F ; R4是CF3或OCF3; 及其生理上可耐受的盐。 还描述了制备式I化合物的方法。 该化合物适用于治疗脂质代谢紊乱。

    Compounds for treating disorders of lipid metabolism and their preparation
    5.
    发明授权
    Compounds for treating disorders of lipid metabolism and their preparation 失效
    用于治疗脂质代谢紊乱及其制备的化合物

    公开(公告)号：US5939424A

    公开(公告)日：1999-08-17

    申请号：US868991

    申请日：1997-06-04

    申请人： Hans Georg Boger ,  Axel Hoffmann ,  Gerhard Jahne ,  Norbert Krass ,  Hans-Ludwig Schafer

    发明人： Hans Georg Boger ,  Axel Hoffmann ,  Gerhard Jahne ,  Norbert Krass ,  Hans-Ludwig Schafer

    IPC分类号： A61K31/505 ,  A61P3/06 ,  C07D403/04

    CPC分类号： C07D403/04

    摘要： The invention relates to 4-Amino-2-ureidopyrimidine-5-carboxamides of the formula I ##STR1## in which R.sup.1 is H or (C.sub.1 -C.sub.8)-alkyl, where one or more H can be replaced by F; R.sup.2 is selected from the group consisting of F, Cl, Br, H, -O-(C.sub.1 -C.sub.8)-alkyl, and -S-(C.sub.1 -C.sub.8)-alkyl, where the alkyl groups have one or more H replaced by F; R.sup.3 is -O-(C.sub.1 -C.sub.8)-alkyl or -S-(C.sub.1 -C.sub.8)-alkyl, where the alkyl groups have one or more H replaced by F; or R.sup.2 and R.sup.3 together form -O-(C.sub.1 -C.sub.5)-alkylene-O-, where the alkylene portion has one or more H replaced by F; and their physiologically tolerable salts. The invention further provides processes for preparing the compounds of formula I. The compounds are suitable for the treatment of disorders of lipid metabolism.

    摘要翻译： 本发明涉及式I的4-氨基-2-脲基嘧啶-5-甲酰胺，其中R 1为H或（C 1 -C 8） - 烷基，其中一个或多个H可被F取代; R 2选自F，Cl，Br，H，-O-（C 1 -C 8） - 烷基和-S-（C 1 -C 8） - 烷基，其中烷基具有一个或多个H被 F; R 3是-O-（C 1 -C 8） - 烷基或-S-（C 1 -C 8） - 烷基，其中烷基具有一个或多个H被F取代; 或R 2和R 3一起形成-O-（C 1 -C 5） - 亚烷基-O-，其中亚烷基部分具有一个或多个H被F取代; 及其生理上可耐受的盐。 本发明还提供了制备式I化合物的方法。该化合物适用于治疗脂质代谢紊乱。

    Composition and method for the oxidative dyeing of hair
    6.
    发明授权
    Composition and method for the oxidative dyeing of hair 失效
    头发氧化染色的组成和方法

    公开(公告)号：US4883656A

    公开(公告)日：1989-11-28

    申请号：US133130

    申请日：1987-11-12

    申请人： Eugen Konrad ,  Herbert Mager ,  Axel Hoffmann

    发明人： Eugen Konrad ,  Herbert Mager ,  Axel Hoffmann

    IPC分类号： A61K8/00 ,  A61K20060101 ,  A61K8/22 ,  A61K8/23 ,  A61K8/33 ,  A61K8/40 ,  A61K8/41 ,  A61K8/46 ,  A61K8/49 ,  A61K8/97 ,  A61Q5/10 ,  D06P20060101 ,  D06P1/32 ,  D06P3/08

    CPC分类号： A61Q5/10 ,  A61K8/415 ,  A61K8/4973

    摘要： A composition and method for the oxidative dyeing of hair based on a combination of coupler substance and developer substance, wherein they contain(A) 5-amino-2-methylphenol as coupler substance and(B) 4-amino-3-methylphenol and(C) 1,4-diaminobenzene and/or 2,5-diaminotolueneas developer substances, also in the form of the physiologically compatible salts.The new composition enables the production of neutral red color shades which are free from yellow and virtually free of blue portions and, in addition to the high dye intensity and brilliance, have an outstanding dye equality with very good absorptive power.

    摘要翻译： PCT No.PCT / EP87 / 00144 Sec。 371日期：1987年11月12日 102（e）日期1987年11月12日PCT 1987年3月12日PCT公布。 公开号WO87 / 05801 日本1987年10月8日。基于成色剂物质和显影剂物质的组合的毛发氧化染色的组合物和方法，其中它们含有（A）5-氨基-2-甲基苯酚作为成色剂物质，和（B）4- 氨基-3-甲基苯酚和（C）1,4-二氨基苯和/或2,5-二氨基甲苯作为显影剂物质，也是生理上相容的盐的形式。 该新组合物能够生产不含黄色并基本上不含蓝色部分的中性红色阴影，除了高染料强度和亮度之外，具有非常好的吸收能力的显着染色性。

    Nanosized biological container and manufacture thereof
    7.
    发明申请
    Nanosized biological container and manufacture thereof 审中-公开
    纳米化生物容器及其制造

    公开(公告)号：US20060240456A1

    公开(公告)日：2006-10-26

    申请号：US11384792

    申请日：2006-03-20

    申请人： Liaohai Chen ,  Samuel Bader ,  Axel Hoffmann ,  Brian Kay ,  Lee Makowski

    发明人： Liaohai Chen ,  Samuel Bader ,  Axel Hoffmann ,  Brian Kay ,  Lee Makowski

    IPC分类号： C12Q1/70 ,  C12Q1/68

    CPC分类号： G01N33/5434 ,  B82Y15/00 ,  B82Y30/00

    摘要： Nanosized biological containers that are “ghosts” of viruses for which capsids are independent of their endogenous viral nucleic acid cores, provide nano-particles of uniform size, and known numbers of sites for attachments of ligands. These containers can be filled with a fluorescent, magnetic, x-ray absorbent, nucleotide components or a radioactive particle and used as nanoscale markers.

    摘要翻译： 作为衣壳与其内源性病毒核酸核心无关的病毒的“鬼魂”的纳米化生物容器提供均匀大小的纳米颗粒，以及已知数目的配体附着位点。 这些容器可以填充荧光，磁性，X射线吸收剂，核苷酸组分或放射性颗粒，并用作纳米级标记。

    PATTERN TRANSFER WITH SELF-SIMILAR SACRIFICIAL MASK LAYER AND VECTOR MAGNETIC FIELD SENSOR
    8.
    发明申请
    PATTERN TRANSFER WITH SELF-SIMILAR SACRIFICIAL MASK LAYER AND VECTOR MAGNETIC FIELD SENSOR 审中-公开
    具有自相似掩模层和矢量磁场传感器的图案转移

    公开(公告)号：US20080088984A1

    公开(公告)日：2008-04-17

    申请号：US11952667

    申请日：2007-12-07

    申请人： Axel Hoffmann

    发明人： Axel Hoffmann

    IPC分类号： G11B5/127

    CPC分类号： B82Y25/00 ,  B82Y10/00 ,  G11B5/3906 ,  G11B2005/3996

    摘要： A method is provided for producing a lithographic pattern using a mask that includes the same materials as the material to be etched, allowing the pattern to be transferred and the etch mask to be removed in one step. In accordance with features of the invention, the method includes building up of a layer or layers of material of specific thickness on top of a substrate so that temporal control of an etching process allows formation of the desired pattern. Different exchange bias directions can be established by the use of shape anisotropy for the exchange biased component of a spin valve device. This enables several different magnetic reference directions to be present on a single chip, which allows a more compact magnetic field sensor to be developed. In accordance with features of the invention, different field directions are established on one single chip by using shape anisotropy

    摘要翻译： 提供了一种使用包括与待蚀刻材料相同的材料的掩模来产生光刻图案的方法，允许图案被转印并且蚀刻掩模在一个步骤中被去除。 根据本发明的特征，该方法包括在衬底的顶部上建立特定厚度的一层或多层材料，使得蚀刻工艺的时间控制允许形成所需图案。 可以通过使用自旋阀装置的交换偏压分量的形状各向异性来建立不同的交换偏压方向。 这使得能够在单个芯片上存在几个不同的磁参考方向，这允许开发更紧凑的磁场传感器。 根据本发明的特征，通过使用形状各向异性，在单个芯片上建立不同的场方向

    Pattern transfer with self-similar sacrificial mask layer and vector magnetic field sensor
    9.
    发明授权
    Pattern transfer with self-similar sacrificial mask layer and vector magnetic field sensor 失效
    模式转移与自相似的牺牲掩模层和矢量磁场传感器

    公开(公告)号：US07323113B2

    公开(公告)日：2008-01-29

    申请号：US10980507

    申请日：2004-11-03

    申请人： Axel Hoffmann

    发明人： Axel Hoffmann

    IPC分类号： B44C1/22

    CPC分类号： B82Y25/00 ,  B82Y10/00 ,  G11B5/3906 ,  G11B2005/3996

    摘要： A method is provided for producing a lithographic pattern using a mask that includes the same materials as the material to be etched, allowing the pattern to be transferred and the etch mask to be removed in one step. In accordance with features of the invention, the method includes building up of a layer or layers of material of specific thickness on top of a substrate so that temporal control of an etching process allows formation of the desired pattern. Different exchange bias directions can be established by the use of shape anisotropy for the exchange biased component of a spin valve device. This enables several different magnetic reference directions to be present on a single chip, which allows a more compact magnetic field sensor to be developed. In accordance with features of the invention, different field directions are established on one single chip by using shape anisotropy.

    摘要翻译： 提供了一种使用包括与待蚀刻材料相同的材料的掩模来产生光刻图案的方法，允许图案被转印并且蚀刻掩模在一个步骤中被去除。 根据本发明的特征，该方法包括在衬底的顶部上建立特定厚度的一层或多层材料，使得蚀刻工艺的时间控制允许形成所需图案。 可以通过使用自旋阀装置的交换偏压分量的形状各向异性来建立不同的交换偏压方向。 这使得能够在单个芯片上存在几个不同的磁参考方向，这允许开发更紧凑的磁场传感器。 根据本发明的特征，通过使用形状各向异性，在单个芯片上建立不同的场方向。

    Magnetic memory using single domain switching by direct current
    10.
    发明申请
    Magnetic memory using single domain switching by direct current 失效

    公开(公告)号：US20060028863A1

    公开(公告)日：2006-02-09

    申请号：US10912708

    申请日：2004-08-05

    申请人： Seok-Hwan Chung ,  Axel Hoffmann

    发明人： Seok-Hwan Chung ,  Axel Hoffmann

    IPC分类号： G11C11/00

    CPC分类号： H01L43/08 ,  G11C11/14 ,  G11C19/0808

    摘要： A method for implementing miniaturization of magnetic random access memory (MRAM) and a magnetic memory using single domain switching by direct current are provided. The magnetic memory preferably includes a half-circle or U-shaped architecture with an exchange biasing pad, such as a FeMn exchange biasing pad that effectively generates a head-to-head magnetization configuration. The magnetic memory also includes nanometer scale notches in order to minimize magnetostatic interaction between a single domain memory element and the spin current sources and to effectively trap the magnetic domain wall. Reading the bit can be carried out by anisotropic magnetoresistance, or by other means of determining the magnetization orientation through resistance measurements, such as a spin valve or a magnetic tunneling junction.