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    Method of producing a compound by fermentation
    5.
    发明授权
    Method of producing a compound by fermentation 失效
    通过发酵生产化合物的方法

    公开(公告)号：US07459294B2

    公开(公告)日：2008-12-02

    申请号：US10913180

    申请日：2004-08-06

    申请人： Timothy A. Leaf ,  Ruchir P. Desai ,  Peter Licari ,  Elaine Jennifer Woo

    发明人： Timothy A. Leaf ,  Ruchir P. Desai ,  Peter Licari ,  Elaine Jennifer Woo

    IPC分类号： C12P19/44 ,  C12P19/60 ,  C12P19/62 ,  C12P17/00 ,  C12P17/02

    CPC分类号： C12P17/08

    摘要： During the production of a product compound by fermentation, the concentration of a precursor compound is maintained within a pre-selected concentration range by having an adsorbent resin in contact with the culture medium. The adsorbent resin reversibly adsorbs precursor compound and, as un-adsorbed precursor compound is converted to product compound, adsorbed precursor compound is released from the resin, thus maintaining the concentration of precursor compound within the pre-selected range.

    摘要翻译： 在通过发酵生产产品化合物期间，通过使吸附树脂与培养基接触，将前体化合物的浓度保持在预先选择的浓度范围内。 吸附剂树脂可逆地吸附前体化合物，当未吸附的前体化合物转化为产物化合物时，吸附的前体化合物从树脂中释放出来，从而将前体化合物的浓度保持在预选范围内。

    Method of producing a compound by fermentation
    7.
    发明申请
    Method of producing a compound by fermentation 失效
    通过发酵生产化合物的方法

    公开(公告)号：US20050130283A1

    公开(公告)日：2005-06-16

    申请号：US10913180

    申请日：2004-08-06

    申请人： Timothy Leaf ,  Ruchir Desai ,  Peter Licari ,  Elaine Woo

    发明人： Timothy Leaf ,  Ruchir Desai ,  Peter Licari ,  Elaine Woo

    IPC分类号： C12N9/00 ,  C12P17/08

    CPC分类号： C12P17/08

    摘要： During the production of a product compound by fermentation, the concentration of a precursor compound is maintained within a pre-selected concentration range by having an adsorbent resin in contact with the culture medium. The adsorbent resin reversibly adsorbs precursor compound and, as un-adsorbed precursor compound is converted to product compound, adsorbed precursor compound is released from the resin, thus maintaining the concentration of precursor compound within the pre-selected range.

    摘要翻译： 在通过发酵生产产品化合物期间，通过使吸附树脂与培养基接触，将前体化合物的浓度保持在预先选择的浓度范围内。 吸附剂树脂可逆地吸附前体化合物，当未吸附的前体化合物转化为产物化合物时，吸附的前体化合物从树脂中释放出来，从而将前体化合物的浓度保持在预选范围内。

    Pharmaceutical solution formulations containing 17-AAG
    9.
    发明申请
    Pharmaceutical solution formulations containing 17-AAG 审中-公开
    含有17-AAG的药物溶液制剂

    公开(公告)号：US20050256097A1

    公开(公告)日：2005-11-17

    申请号：US11123570

    申请日：2005-05-05

    申请人： Ziyang Zhong ,  Peter Licari

    发明人： Ziyang Zhong ,  Peter Licari

    IPC分类号： A61K31/20 ,  A61K31/33

    CPC分类号： A61K31/20 ,  A61K31/33

    摘要： A pharmaceutical solution formulation containing 17-AAG in an amount of up to 15 mg/mL dissolved in a vehicle comprising (i) a first component that is ethanol, in an amount of between about 40 and about 60 volume %; (ii) a second component that is a polyethoxylated castor oil, in an amount of between about 15 to about 50 volume %; and (iii) a third component that is selected from the group consisting of propylene glycol, PEG 300, PEG 400, glycerol, and combinations thereof, in an amount of between about 0 and about 35 volume %.

    摘要翻译： 溶解在载体中的含有高达15mg / mL的量的17-AAG的药物溶液制剂，其包含（i）第一组分，其量为约40至约60体积％; （ii）作为聚乙氧基化蓖麻油的第二组分，其量为约15至约50体积％; 和（iii）选自丙二醇，PEG 300，PEG 400，甘油及其组合的第三组分，其量为约0至约35体积％。