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公开(公告)号：US08735066B2
公开(公告)日：2014-05-27
申请号：US13453324
申请日：2012-04-23
IPC分类号： C12Q1/68
CPC分类号： G01N33/57496 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/4703 , C12N9/16 , C12N2799/021 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/16 , C12Q2600/172 , G01N33/57407 , G01N33/57434 , G01N2333/916
摘要： A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.
摘要翻译： 染色体10的特定区域（10q23.3）已被一系列研究涉及到包含参与神经胶质瘤的肿瘤抑制基因以及许多其他人类癌症。 鉴定出该区域内的一个基因，该基因的相应编码区代表一种新的47kD蛋白。 该产品的结构域与蛋白酪氨酸磷酸酶的保守催化结构域完全一致，表明在磷酸化事件中可能发挥功能作用。 序列分析表明，在用于定义10q23.3区域的肿瘤细胞系中，该基因的多个外显子被缺失，导致该基因作为肿瘤抑制基因的分类。 进一步的分析已经证明在神经胶质瘤和前列腺癌细胞中基因中存在许多突变。 还公开了用于诊断和治疗与该肿瘤抑制因子相关的癌症的方法，称为TS10q23.3。
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公开(公告)号：US07129040B2
公开(公告)日：2006-10-31
申请号：US10979642
申请日：2004-11-01
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/48 , G01N33/566
CPC分类号： G01N33/57496 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/4703 , C12N9/16 , C12N2799/021 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/16 , C12Q2600/172 , G01N33/57407 , G01N33/57434 , G01N2333/916
摘要： A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.
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公开(公告)号：US06482795B1
公开(公告)日：2002-11-19
申请号：US09140749
申请日：1998-08-26
IPC分类号： A61K3800
CPC分类号： G01N33/57496 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/4703 , C12N9/16 , C12N2799/021 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/16 , C12Q2600/172 , G01N33/57407 , G01N33/57434 , G01N2333/916
摘要： A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.
摘要翻译： 染色体10的特定区域（10q23.3）已被一系列研究涉及到包含参与神经胶质瘤的肿瘤抑制基因以及许多其他人类癌症。 鉴定出该区域内的一个基因，该基因的相应编码区代表一种新的47kD蛋白。 该产品的结构域与蛋白酪氨酸磷酸酶的保守催化结构域完全一致，表明在磷酸化事件中可能发挥功能作用。 序列分析表明，在用于定义10q23.3区域的肿瘤细胞系中，该基因的多个外显子被缺失，导致该基因作为肿瘤抑制基因的分类。 进一步的分析已经证明在神经胶质瘤和前列腺癌细胞中基因中存在许多突变。 还公开了用于诊断和治疗与该肿瘤抑制因子相关的癌症的方法，称为TS10q23.3。
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公开(公告)号：US07732576B2
公开(公告)日：2010-06-08
申请号：US11590556
申请日：2006-10-30
IPC分类号： C07K16/00
CPC分类号： G01N33/57496 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/4703 , C12N9/16 , C12N2799/021 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/16 , C12Q2600/172 , G01N33/57407 , G01N33/57434 , G01N2333/916
摘要： A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.
摘要翻译： 染色体10的特定区域（10q23.3）已被一系列研究涉及到包含参与神经胶质瘤的肿瘤抑制基因以及许多其他人类癌症。 鉴定出该区域内的一个基因，该基因的相应编码区代表一种新的47kD蛋白。 该产品的结构域与蛋白酪氨酸磷酸酶的保守催化结构域完全一致，表明在磷酸化事件中可能发挥功能作用。 序列分析表明，在用于定义10q23.3区域的肿瘤细胞系中，该基因的多个外显子被缺失，导致该基因作为肿瘤抑制基因的分类。 进一步的分析已经证明在神经胶质瘤和前列腺癌细胞中基因中存在许多突变。 还公开了用于诊断和治疗与该肿瘤抑制因子相关的癌症的方法，称为TS10q23.3。
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公开(公告)号：US07217795B2
公开(公告)日：2007-05-15
申请号：US10299003
申请日：2002-11-19
IPC分类号： C07K16/00
CPC分类号： G01N33/57496 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/4703 , C12N9/16 , C12N2799/021 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/16 , C12Q2600/172 , G01N33/57407 , G01N33/57434 , G01N2333/916
摘要： A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.
摘要翻译： 染色体10的特定区域（10q23.3）已被一系列研究涉及到包含参与神经胶质瘤的肿瘤抑制基因以及许多其他人类癌症。 鉴定出该区域内的一个基因，该基因的相应编码区代表一种新的47kD蛋白。 该产品的结构域与蛋白酪氨酸磷酸酶的保守催化结构域完全一致，表明在磷酸化事件中可能发挥功能作用。 序列分析表明，在用于定义10q23.3区域的肿瘤细胞系中，该基因的多个外显子被缺失，导致该基因作为肿瘤抑制基因的分类。 进一步的分析已经证明在神经胶质瘤和前列腺癌细胞中基因中存在许多突变。 还公开了用于诊断和治疗与该肿瘤抑制因子相关的癌症的方法，称为TS10q23.3。
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公开(公告)号：US20100190176A1
公开(公告)日：2010-07-29
申请号：US12752827
申请日：2010-04-01
CPC分类号： G01N33/57496 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/4703 , C12N9/16 , C12N2799/021 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/16 , C12Q2600/172 , G01N33/57407 , G01N33/57434 , G01N2333/916
摘要： A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.
摘要翻译： 染色体10的特定区域（10q23.3）已被一系列研究涉及到包含参与神经胶质瘤的肿瘤抑制基因以及许多其他人类癌症。 鉴定出该区域内的一个基因，该基因的相应编码区代表一种新的47kD蛋白。 该产品的结构域与蛋白酪氨酸磷酸酶的保守催化结构域完全一致，表明在磷酸化事件中可能发挥功能作用。 序列分析表明，在用于定义10q23.3区域的肿瘤细胞系中，该基因的多个外显子被缺失，导致该基因作为肿瘤抑制基因的分类。 进一步的分析已经证明在神经胶质瘤和前列腺癌细胞中基因中存在许多突变。 还公开了用于诊断和治疗与该肿瘤抑制因子相关的癌症的方法，称为TS10q23.3。
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公开(公告)号：US20120315631A1
公开(公告)日：2012-12-13
申请号：US13453324
申请日：2012-04-23
CPC分类号： G01N33/57496 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/4703 , C12N9/16 , C12N2799/021 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/16 , C12Q2600/172 , G01N33/57407 , G01N33/57434 , G01N2333/916
摘要： A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.
摘要翻译： 染色体10的特定区域（10q23.3）已被一系列研究涉及到包含参与神经胶质瘤的肿瘤抑制基因以及许多其他人类癌症。 鉴定出该区域内的一个基因，该基因的相应编码区代表一种新的47kD蛋白。 该产品的结构域与蛋白酪氨酸磷酸酶的保守催化结构域完全一致，表明在磷酸化事件中可能发挥功能作用。 序列分析表明，在用于定义10q23.3区域的肿瘤细胞系中，该基因的多个外显子被缺失，导致该基因作为肿瘤抑制基因的分类。 进一步的分析已经证明在神经胶质瘤和前列腺癌细胞中基因中存在许多突变。 还公开了用于诊断和治疗与该肿瘤抑制因子相关的癌症的方法，称为TS10q23.3。
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公开(公告)号：US06262242B1
公开(公告)日：2001-07-17
申请号：US08791115
申请日：1997-01-30
IPC分类号： C07H204
CPC分类号： C12N9/16 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/4703 , C12N2799/021
摘要： A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.
摘要翻译： 染色体10的特定区域（10q23.3）已被一系列研究涉及到包含参与神经胶质瘤的肿瘤抑制基因以及许多其他人类癌症。 鉴定出该区域内的一个基因，该基因的相应编码区代表一种新的47kD蛋白。 该产品的结构域与蛋白酪氨酸磷酸酶的保守催化结构域完全一致，表明在磷酸化事件中可能发挥功能作用。 序列分析表明，在用于定义10q23.3区域的肿瘤细胞系中，该基因的多个外显子被缺失，导致该基因作为肿瘤抑制基因的分类。 进一步的分析已经证明在神经胶质瘤和前列腺癌细胞中基因中存在许多突变。 还公开了用于诊断和治疗与该肿瘤抑制因子相关的癌症的方法，称为TS10q23.3。
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9.发明授权Chromosome 17p-linked prostate cancer susceptibility gene and a paralog and orthologous genes 失效染色体17p连接的前列腺癌易感基因和旁系同源和直系同源基因公开(公告)号：US06333403B1
公开(公告)日：2001-12-25
申请号：US09564805
申请日：2000-05-05
IPC分类号： C07H2104
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4748 , C07K16/3069 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156
摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human prostate cancer predisposing gene (HPC2), some alleles of which cause susceptibility to cancer, in particular prostate cancer. More specifically, the present invention relates to germline mutations in the HPC2 gene and their use in the diagnosis of predisposition to prostate cancer. The invention also relates to presymptomatic therapy of individuals who carry deleterious alleles of the HPC2 gene. The invention further relates to somatic mutations in the HPC2 gene in human prostate cancer and their use in the diagnosis and prognosis of human prostate cancer. Additionally, the invention relates to somatic mutations in the HPC2 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the HPC2 gene, (including gene therapy, protein replacement therapy, protein mimetics, and inhibitors). The invention further relates to the screening of drugs for cancer therapy. The invention also relates to the screening of the HPC2 gene for mutations, which are useful for diagnosing the predisposition to prostate cancer. In addition, the invention relates to a paralog of human HPC2, the paralog being named ELAC1, and to orthologs of human HPC2, these being mouse Elac2, chimpanzee Elac2 and gorilla Elac2.
摘要翻译： 本发明一般涉及人类遗传学领域。 具体地，本发明涉及用于分离和检测人前列腺癌易感基因（HPC2）的方法和材料，其一些等位基因导致癌症易感性，特别是前列腺癌。 更具体地，本发明涉及HPC2基因中的种系突变及其在诊断前列腺癌易感性中的用途。 本发明还涉及带有HPC2基因有害等位基因的个体的症状前症状。 本发明还涉及人前列腺癌中HPC2基因中的体细胞突变及其在人前列腺癌诊断和预后中的应用。 此外，本发明涉及其他人类癌症中HPC2基因中的体细胞突变及其在人类癌症的诊断和预后中的应用。 本发明还涉及在HPC2基因中具有突变（包括基因治疗，蛋白质替代疗法，蛋白质模拟物和抑制剂）的人类癌症的治疗。 本发明还涉及用于癌症治疗的药物的筛选。 本发明还涉及用于突变的HPC2基因的筛选，其可用于诊断前列腺癌的倾向。 此外，本发明涉及人HPC2，旁系同源异型片段命名为ELAC1的旁系同源物，以及人HPC2的直向同源物，这些是人ElC2，黑猩猩Elac2和大猩猩Elac2。
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公开(公告)号：US06331614B1
公开(公告)日：2001-12-18
申请号：US09468872
申请日：1999-12-22
IPC分类号： C07H2104
CPC分类号： C12N9/16 , C12Y301/03048
摘要： The present invention relates generally to the field of human genetics. Specifically, the present invention relates to human CDC14A gene which has been found to be mutated in certain tumor cell lines. More specifically, the invention relates to a novel sequence for the human CDC14A gene. The present invention further relates to somatic mutations in the CDC14A gene in human cancer and their use in the diagnosis and prognosis of human cancer. The invention also relates to the therapy of human cancers which have a mutation in the CDC14A gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the CDC14A gene for mutations, which are useful for diagnosing the predisposition to cancer.
摘要翻译： 本发明一般涉及人类遗传学领域。 具体地说，本发明涉及已被发现在某些肿瘤细胞系中突变的人CDC14A基因。 更具体地，本发明涉及人CDC14A基因的新序列。 本发明还涉及人类癌症中CDC14A基因中的体细胞突变及其在人类癌症的诊断和预后中的用途。 本发明还涉及在CDC14A基因中具有突变的人类癌症的治疗，包括基因治疗，蛋白质替代疗法和蛋白质模拟物。 本发明还涉及用于癌症治疗的药物的筛选。 最后，本发明涉及用于突变的CDC14A基因的筛选，其可用于诊断癌症的易感性。
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