公开(公告)号：US20070287713A1

公开(公告)日：2007-12-13

申请号：US11779319

申请日：2007-07-18

申请人： Peter Cheng ,  Sean Chen ,  Pratik Devasthale ,  Charles Ding ,  Timothy Herpin ,  Shung Wu ,  Hao Zhang ,  Wei Wang ,  Xiang-Yang Ye

发明人： Peter Cheng ,  Sean Chen ,  Pratik Devasthale ,  Charles Ding ,  Timothy Herpin ,  Shung Wu ,  Hao Zhang ,  Wei Wang ,  Xiang-Yang Ye

IPC分类号： A61K31/41 ,  A61K31/42 ,  A61K31/44 ,  A61K31/445 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/505 ,  A61P3/10 ,  C07D239/02 ,  C07D257/00 ,  C07D263/30 ,  C07D271/06 ,  C07D401/02 ,  C07D403/02 ,  C07D413/02

CPC分类号： C07D413/12 ,  C07D413/14

摘要： wherein Z1 is (CH2)q or C═O; Z2 is (CH2)p or C═O; D is —CH═ or C═O or (CH2)m where m is 0, 1, 2 or 3; n=0, 1 or 2; p=1 or 2; q=0, 1 or 2; Q is C or N; A is (CH2)x where x is 1 to 5, or A is (CH2)x1, where x1 is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is —(CH2)x2—O—(CH2)x3— where x2 is 0 to 5 and x3 is 0 to 5, provided that at least one of x2 and x3 is other than 0; B is a bond or is (CH2)x4 where x4 is 1 to 5; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4 X5 and X6 is C. R1 is H or alkyl; R2 is H, alkyl, alkoxy, halogen, amino, substituted amino or cyano; R2a, R2b and R2c may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino, substituted amino or cyano; and R3, E, Z and Y are as defined herein.

公开(公告)号：US07951793B2

公开(公告)日：2011-05-31

申请号：US11779319

申请日：2007-07-18

申请人： Peter T. W. Cheng ,  Sean Chen ,  Pratik Devasthale ,  Charles Z. Ding ,  Timothy F. Herpin ,  Shung Wu ,  Hao Zhang ,  Wei Wang ,  Xiang-Yang Ye

发明人： Peter T. W. Cheng ,  Sean Chen ,  Pratik Devasthale ,  Charles Z. Ding ,  Timothy F. Herpin ,  Shung Wu ,  Hao Zhang ,  Wei Wang ,  Xiang-Yang Ye

IPC分类号： A61K31/397 ,  C07D205/08 ,  A01N43/00

CPC分类号： C07D413/12 ,  C07D413/14

摘要： Compounds are provided which have the structure wherein Z1 is (CH2)q or C═O; Z2 is (CH2)p or C═O; D is —CH═ or C═O or (CH2)m where m is 0, 1, 2 or 3; n=0, 1 or 2; p=1 or 2; q=0, 1 or 2; Q is C or N; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4 X5 and X6 is C; and A, B, R1, R2, R2a, R4, R3, E, Z and Y are as defined herein, which compounds are useful in treating diabetes and related diseases.

摘要翻译： 提供具有其中Z 1是（CH 2）q或C = O的结构的化合物; Z2是（CH2）p或C = O; D是-CH =或C = O或（CH 2）m，其中m为0,1,2或3; n = 0,1或2; p = 1或2; q = 0,1或2; Q是C或N; X是CH或N; X2是C，N，O或S; X3为C，N，O或S; X4为C，N，O或S; X5为C，N，O或S; X6为C，N，O或S; 条件是X 2，X 3，X 4 X 5和X 6中的至少一个为N; X2，X3，X4，X5和X6中的至少一个为C; 并且A，B，R1，R2，R2a，R4，R3，E，Z和Y如本文所定义，该化合物可用于治疗糖尿病和相关疾病。

公开(公告)号：US07279485B2

公开(公告)日：2007-10-09

申请号：US10616365

申请日：2003-07-08

申请人： Peter T. W. Cheng ,  Sean Chen ,  Pratik Devasthale ,  Charles Z. Ding ,  Timothy F. Herpin ,  Shung Wu ,  Hao Zhang ,  Wei Wang ,  Xiang-Yang Ye

发明人： Peter T. W. Cheng ,  Sean Chen ,  Pratik Devasthale ,  Charles Z. Ding ,  Timothy F. Herpin ,  Shung Wu ,  Hao Zhang ,  Wei Wang ,  Xiang-Yang Ye

IPC分类号： A01N43/54 ,  A01N43/76 ,  A61K31/505 ,  C07D239/02 ,  C07D413/00

CPC分类号： C07D413/12 ,  C07D413/14

摘要： Substituted heterocyclic derivatives are provided which have the structure wherein Z1 is (CH2)q or C═O; Z2 is (CH2)p or C═O; D is —CH═ or C═O or (CH2)m where m is 0, 1, 2 or 3; n=0, 1 or 2; p=1 or 2; q=0, 1 or 2; Q is C or N; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4, X5 and X6 is N; and at least one of X2, X3, X4, X5 and X6 is C; A, B, R1, R2, R2a, R2b, R4, R3, E, Z and Y are as defined herein. In addition, a method is provided for treating diabetes, Type 2 diabetes, insulin resistance, hyperglycemia, hyperinsulinemia, elevated blood levels of fatty acids or glycerol, hyperlipidemia, obesity, hypertriglyceridemia, Syndrome X, or atherosclerosis, wherein the substituted heterocyclic derivatives are administered in a therapeutically effective amount to a patient.

摘要翻译： 提供了取代的杂环衍生物，其具有其中Z 1是（CH 2 CH 2）q或C-O的结构; Z 2是（CH 2）2或C-O; D是-CH-或C-O或（CH 2 CH 2）m，其中m是0,1,2或3; n = 0,1或2; p = 1或2; q = 0,1或2; Q是C或N; X是CH或N; X 2是C，N，O或S; X 3是C，N，O或S; X 4是C，N，O或S; X 5是C，N，O或S; X 6是C，N，O或S; 条件是X 2，X 3，X 4，X 5和X 3中的至少一个， 6是N; 和X 2，X 3，X 4，X 5和X 6中的至少一个 是C; A，B，R 1，R 2，R 2a，R 2b，R 4， R 3，R 3，E，Z和Y如本文所定义。 另外，提供了一种治疗糖尿病，2型糖尿病，胰岛素抵抗，高血糖症，高胰岛素血症，升高的脂肪酸或甘油血糖水平，高脂血症，肥胖症，高甘油三酯血症，综合征X或动脉粥样硬化的方法，其中给予取代的杂环衍生物 以治疗有效量给予患者。

公开(公告)号：US20070015797A1

公开(公告)日：2007-01-18

申请号：US11155965

申请日：2005-08-22

申请人： Peter Cheng ,  Pratik Devasthale ,  Yoon Jeon ,  Sean Chen ,  Hao Zhang

发明人： Peter Cheng ,  Pratik Devasthale ,  Yoon Jeon ,  Sean Chen ,  Hao Zhang

IPC分类号： A61K31/4439 ,  A61K31/421 ,  C07D413/02 ,  C07D263/34

CPC分类号： C07D263/32 ,  C07D277/24 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D495/04

摘要： Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R2c, R3, Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.

公开(公告)号：US20050119311A1

公开(公告)日：2005-06-02

申请号：US10964395

申请日：2004-10-13

申请人： Peter Cheng ,  Pratik Devasthale ,  Yoon Jeon ,  Sean Chen ,  Hao Zhang

发明人： Peter Cheng ,  Pratik Devasthale ,  Yoon Jeon ,  Sean Chen ,  Hao Zhang

IPC分类号： C07D263/32 ,  C07D263/58 ,  C07D277/24 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D495/04 ,  C07D521/00 ,  C07D417/14 ,  A61K31/4439 ,  A61K31/444

CPC分类号： C07D263/58 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D263/32 ,  C07D277/24 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D495/04

摘要： Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R2c, R3, Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.

摘要翻译： 提供具有其中Q为C或N，A为O或S，Z为O或键，X为CH或N，R 1，R 2， R 2，R 2b，R 2b，R 2c，R 3，Y，x，m和 n如本文所定义，这些化合物可用作抗糖尿病，降血脂症和抗肥胖剂。

公开(公告)号：US20050119312A1

公开(公告)日：2005-06-02

申请号：US11016183

申请日：2004-12-17

申请人： Peter Cheng ,  Sean Chen ,  Charles Ding ,  Timothy Herpin

发明人： Peter Cheng ,  Sean Chen ,  Charles Ding ,  Timothy Herpin

IPC分类号： A61K31/41 ,  A61K31/42 ,  A61K31/435 ,  A61K31/50 ,  A61K31/52 ,  C07D233/54 ,  C07D249/06 ,  C07D263/32 ,  C07D271/06 ,  C07D413/12 ,  C07D417/14 ,  A61K31/4439 ,  A61K31/444 ,  C07D413/14

CPC分类号： C07D233/64 ,  C07D249/06 ,  C07D263/32 ,  C07D271/06 ,  C07D413/12

摘要： Compounds are provided which are useful as antidiabetic agents and antiobesity agents and have the structure wherein m is 0, 1 or 2; n is 0, 1 or 2; Q is C or N; A is (CH2)x where x is 1 to 5, or A is (CH2)x1 where x1 is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is —(CH2)x2—O—(CH2)x3— where x2 is 0 to 5 and x3 is 0 to 5, provided that at least one of x2 and x3 is other than 0; B is a bond or is (CH2)x4 where x4 is 1 to 5; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N; O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4 X5 and X6 is C, and specifically excluding the structure(s) as shown below: where X2═N, X3═C, X4═O or S, Z=O or a bond R1 is H or alkyl; R2 is H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; R2a, R2b and R2c may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; and R3 and Y are as defined herein, which compounds are useful in treating diabetes and obesity.

公开(公告)号：US07084162B2

公开(公告)日：2006-08-01

申请号：US10655876

申请日：2003-09-05

申请人： Peter T. Cheng ,  Pratik Devasthale ,  Yoon Jeon ,  Sean Chen ,  Hao Zhang

发明人： Peter T. Cheng ,  Pratik Devasthale ,  Yoon Jeon ,  Sean Chen ,  Hao Zhang

IPC分类号： A61K31/421 ,  C07D263/32

CPC分类号： C07D263/58 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D263/32 ,  C07D277/24 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D495/04

摘要： Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R2c, R3, Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.

摘要翻译： 提供具有其中Q为C或N，A为O或S，Z为O或键，X为CH或N，R 1，R 2， R 2，R 2b，R 2b，R 2c，R 3，Y，x，m和 n如本文所定义，这些化合物可用作抗糖尿病，降血脂症和抗肥胖剂。

公开(公告)号：US06919358B2

公开(公告)日：2005-07-19

申请号：US10080965

申请日：2002-02-22

申请人： Peter T. Cheng ,  Pratik Devasthale ,  Yoon Jeon ,  Sean Chen ,  Hao Zhang

发明人： Peter T. Cheng ,  Pratik Devasthale ,  Yoon Jeon ,  Sean Chen ,  Hao Zhang

IPC分类号： C07D263/32 ,  C07D263/58 ,  C07D277/24 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D495/04 ,  C07D521/00 ,  A61K31/443

CPC分类号： C07D263/58 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D263/32 ,  C07D277/24 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D495/04

摘要： Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R2c, R3, Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.

公开(公告)号：US07053106B2

公开(公告)日：2006-05-30

申请号：US10737210

申请日：2003-12-16

申请人： Peter T. Cheng ,  Pratik Devasthale ,  Yoon Jeon ,  Sean Chen ,  Hao Zhang

发明人： Peter T. Cheng ,  Pratik Devasthale ,  Yoon Jeon ,  Sean Chen ,  Hao Zhang

IPC分类号： A61K31/44 ,  A61K31/425 ,  A61K31/42

CPC分类号： C07D263/58 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D263/32 ,  C07D277/24 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D495/04

摘要： Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R3, Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.

摘要翻译： 提供具有其中Q为C或N，A为O或S，Z为O或键，X为CH或N，R 1，R 2， R 2，R 2b，R 2b，R 3，Y，x，m和n如本文所定义，该化合物是有用的 作为抗糖尿病，降血脂药和抗肥胖剂。

公开(公告)号：US06414002B1

公开(公告)日：2002-07-02

申请号：US09812960

申请日：2001-03-20

申请人： Peter T. Cheng ,  Pratik Devasthale ,  Yoon Jeon ,  Sean Chen ,  Hao Zhang

发明人： Peter T. Cheng ,  Pratik Devasthale ,  Yoon Jeon ,  Sean Chen ,  Hao Zhang

IPC分类号： A61K3142

CPC分类号： C07D263/58 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D263/32 ,  C07D277/24 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D495/04

摘要： Compounds are provided which have the structure wherein Q is C or N, A is 0 or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R2c, R3, Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.

摘要翻译： 提供具有结构的化合物，其中Q为C或N，A为O或S，Z为O或键，X为CH或N，R1，R2，R2a，R2b，R2c，R3，Y，x，m， 和n如本文所定义，这些化合物可用作抗糖尿病，降血脂症和抗肥胖剂。