公开(公告)号：US4421931A

公开(公告)日：1983-12-20

申请号：US338243

申请日：1982-01-11

申请人： Peter Tonne ,  Winfried Ludwig ,  Gerhard Kilpper ,  Johannes Grimmer

发明人： Peter Tonne ,  Winfried Ludwig ,  Gerhard Kilpper ,  Johannes Grimmer

IPC分类号： C07C231/00 ,  C07C233/00 ,  C07C102/04 ,  C07C103/28 ,  C07C103/76

CPC分类号： C07C231/00 ,  C07C233/00

摘要： Anthranilic acid amides are prepared by mixing phthalamic acid with a caustic alkali solution, a catalyst and a hypohalite, allowing the mixture to stand for from 1 to 1,000 seconds, then introducing the amine and thereafter addig acid until the pH of the mixture is from 6 to 8.The anthranilic acid amides obtainable by the process of the invention are valuable starting materials for the preparation of dyes, scents and pesticides.

摘要翻译： 邻氨基苯甲酸酰胺通过将邻苯二甲酰氨基磺酸与苛性碱溶液，催化剂和次卤酸盐混合，使混合物静置1至1,000秒，然后引入胺然后加入酸直至混合物的pH为6 通过本发明的方法获得的邻氨基苯甲酰胺是用于制备染料，香料和农药的有价值的原料。

公开(公告)号：US4328339A

公开(公告)日：1982-05-04

申请号：US209960

申请日：1980-11-24

申请人： Gerhard Kilpper ,  Johannes Grimmer ,  Peter Tonne ,  Hans C. Horn ,  Eckhard Hetzel

发明人： Gerhard Kilpper ,  Johannes Grimmer ,  Peter Tonne ,  Hans C. Horn ,  Eckhard Hetzel

IPC分类号： C07D265/26

CPC分类号： C07D265/26

摘要： A process for the continuous preparation of isatoic anhydrides by two-stage reaction of an alkali metal phthalamate and/or alkali metal phthalimidate with an alkali metal hypohalite, the first stage being carried out substantially adiabatically and both stages being carried out at high flow rates, wherein phthalimide and/or phthalamic acid is first dissolved in a certain amount of an alkali metal hydroxide solution, the resulting solution is mixed with a hypohalite and reacted at a particular temperature, acid is then added and the reaction is completed at a particular temperature. The compounds obtainable by the process of the invention are valuable starting materials for the preparation of dyes, crop protection agents and scents.

摘要翻译： 通过碱金属酞酸盐和/或碱金属邻苯二甲酰亚胺酸盐与碱金属次卤酸盐的两步反应连续制备酸酐的方法，第一阶段基本上绝热地进行，两个阶段以高流速进行， 其中邻苯二甲酰亚胺和/或邻苯二甲酰氨基酸首先溶解在一定量的碱金属氢氧化物溶液中，将所得溶液与次卤酸盐混合并在特定温度下反应，然后加入酸，并在特定温度下完成反应。 通过本发明的方法可获得的化合物是用于制备染料，作物保护剂和香料的有价值的起始材料。

公开(公告)号：US4419519A

公开(公告)日：1983-12-06

申请号：US278697

申请日：1981-06-29

申请人： Gerhard Kilpper ,  Johannes Grimmer

发明人： Gerhard Kilpper ,  Johannes Grimmer

IPC分类号： C07D209/48

CPC分类号： C07D209/48

摘要： A process for the continuous preparation of phthalimide by reacting phthalic anhydride with ammonia in about the stoichiometric ratio, in a mixing apparatus and subsequently in a reaction tube at a particular flow velocity and a particular temperature.The phthalimide obtainable by the process of the invention is a valuable starting material for the preparation of dyes, pesticides and pigments, especially copper phthalocyanines.

摘要翻译： 在混合装置中，随后在特定流速和特定温度下在反应管中，以邻苯二甲酸酐与氨以大约化学计量比的比例连续制备邻苯二甲酰亚胺的方法。 通过本发明方法获得的邻苯二甲酰亚胺是用于制备染料，农药和颜料，特别是铜酞菁的有价值的原料。

公开(公告)号：US4276433A

公开(公告)日：1981-06-30

申请号：US2333

申请日：1979-01-10

申请人： Gerhard Kilpper ,  Johannes Grimmer

发明人： Gerhard Kilpper ,  Johannes Grimmer

IPC分类号： C07C101/54

CPC分类号： C07C227/04

摘要： A process for the continuous preparation of anthranilic acid by a two-stage reaction of an alkali metal phthalamate and/or an alkali metal phthalimidate with an alkali metal hypohalite, the first stage being carried out substantially adiabatically and both stages being carried out at high flow rates and different temperatures, wherein first the phthalimide and/or phthalamic acid is dissolved in a defined excess amount of alkali metal hydroxide solution and the solution is only then mixed, and reacted, with the hypohalite, without further addition of excess alkali. The products are starting materials for the preparation of dyes and scents.

摘要翻译： 通过碱金属酞酸盐和/或碱金属邻苯二甲酰亚胺酸盐与碱金属次卤酸盐的两步反应连续制备邻氨基苯甲酸的方法，第一阶段基本上绝热地进行，两个阶段以高流量进行 速率和不同的温度，其中首先将邻苯二甲酰亚胺和/或邻苯二甲酰氨基酸溶解在规定的过量碱金属氢氧化物溶液中，然后将溶液与次卤酸盐混合，并与另外加入过量的碱反应。 该产品是用于制备染料和香料的起始原料。

公开(公告)号：US4233459A

公开(公告)日：1980-11-11

申请号：US24829

申请日：1979-03-28

申请人： Gerhard Kilpper ,  Johannes Grimmer

发明人： Gerhard Kilpper ,  Johannes Grimmer

IPC分类号： C07C99/00 ,  C07C99/12

CPC分类号： C07C227/22

摘要： Anthranilic acid is manufactured continuously by reacting an alkali metal phthalamate and/or phthalimidate with an alkali metal hypohalite in a reaction tube, the resulting anthranilic acid being treated, during or after the reaction, with reducing agents in two steps, the reducing agents employed in the two steps being different from one another, and an alkali metal dithionite or alkali metal formaldehyde-sulfoxylate being used as the reducing agent in the second treatment step. The product is a starting material for the preparation of dyes, crop protection agents and scents.

摘要翻译： 在反应管中使碱金属酞酸盐和/或邻苯二甲酰亚胺酸与碱金属次卤酸盐反应制备邻氨基苯甲酸，所得的邻氨基苯甲酸在反应过程中或反应后用还原剂两步处理，还原剂用于 两个步骤彼此不同，并且在第二处理步骤中使用碱金属连二亚硫酸盐或碱金属甲醛 - 次硫酸盐作为还原剂。 该产品是制备染料，作物保护剂和香料的起始原料。

公开(公告)号：US5210023A

公开(公告)日：1993-05-11

申请号：US724056

申请日：1991-07-01

申请人： Johannes Grimmer ,  Hans Kiefer ,  Christoph Martin

发明人： Johannes Grimmer ,  Hans Kiefer ,  Christoph Martin

IPC分类号： C07D475/14 ,  C12P17/18

CPC分类号： C07D475/14

摘要： A method of purifying ferment-produced riboflavin, wherein the impure riboflavin is suspended in water or dilute aqueous acid, and the suspension is heated at a temperature of from 75.degree. to 130.degree. C. for from 0.3 to 3 hours with stirring, during which time crystal transformation takes place, after which the mixture is cooled and the purified product is isolated in known manner.

摘要翻译： 一种纯化发酵生产的核黄素的方法，其中不纯的核黄素悬浮在水中或稀释酸水溶液，悬浮液在75-130℃的温度下搅拌加热0.3-3小时，在此期间 发生时间晶体转变，然后将混合物冷却，以已知方式分离纯化产物。

公开(公告)号：US5017700A

公开(公告)日：1991-05-21

申请号：US413590

申请日：1989-09-28

申请人： Johannes Grimmer ,  Hans Kiefer

发明人： Johannes Grimmer ,  Hans Kiefer

IPC分类号： A61K31/675 ,  A61P3/02 ,  C07F9/6561 ,  C07F9/6574

CPC分类号： C07F9/65742

摘要： Riboflavin-4',5'-cyclophosphoric acid chloride of the formula I ##STR1## its preparation by reacting an alkali metal salt of riboflavin, in an aprotic solvent, with phosphorus oxychloride, its use for the preparation of riboflavin-5'-phosphate and of the sodium salt of riboflavin-5'-phosphate, and a process for the preparation of riboflavin-5'-phosphate or its sodium salt via the novel phosphoric acid ester chloride.

摘要翻译： 核黄素-4'，5'-环磷酰氯通式Ⅰ（Ⅰ）其核苷酸碱金属盐在非质子传递溶剂中与磷酰氯反应，其用于制备核黄素-5 β-磷酸盐和核黄素-5'-磷酸钠钠盐，以及通过新型磷酸酯氯化物制备核黄素-5'-磷酸或其钠盐的方法。

公开(公告)号：US20070219383A1

公开(公告)日：2007-09-20

申请号：US11662440

申请日：2005-09-08

申请人： Johannes Grimmer ,  Thomas Muller

发明人： Johannes Grimmer ,  Thomas Muller

IPC分类号： C07D317/64 ,  C01C1/00 ,  C07C403/08 ,  C07C45/00

CPC分类号： C07C403/24 ,  C07C403/08 ,  C07C2601/16

摘要： The present invention relates to a method for preparing cyclohexene derivatives of the general formulae I or II by reducing alkyne compounds of the general formulae III or IV with a mixture of zinc and at least one ammonium salt of the formula V as reducing agent, in which the substituents R1 to R8 have independently of one another the meaning specified in the description, wherein the reducing agent comprises from 0.3 to 0.49 mol of at least one ammonium salt of the formula V per mol of zinc.

摘要翻译： 本发明涉及通过用通式Ⅴ的锌和至少一种铵盐作为还原剂的混合物还原通式III或Ⅳ的炔化合物来制备通式I或II的环己烯衍生物的方法，其中 取代基R 1至R 8彼此独立地具有说明书中指定的含义，其中还原剂包含0.3至0.49mol的至少一种铵盐 式V每摩尔锌。

公开(公告)号：US4806643A

公开(公告)日：1989-02-21

申请号：US932312

申请日：1986-11-19

申请人： Johannes Grimmer

发明人： Johannes Grimmer

IPC分类号： C07D475/14

CPC分类号： C07D475/14

摘要： Riboflavin of the formula I ##STR1## is prepared by an improved process by condensing a 4,5-dimethyl-N-(D)-ribityl-2-phenylazoaniline of the formula II ##STR2## where R is H, --CL, --NO.sub.2, --CH.sub.3 or --OCH.sub.3 in the o- or p-position, with barbituric acid of the formula III ##STR3## in the presence of an acid as a condensing agent, by a process in which the acidic condensing agent used is an aliphatic secondary carboxylic acid of the general formula IV ##STR4## where R.sup.1 is methyl or ethyl and R.sup.2 is alkyl of 3 or 4 carbon atoms.

摘要翻译： 式I（I）的核黄素通过将下式（II）的4,5-二甲基-N-（D） - 二基-2-苯基偶氮苯胺缩合得到改进的方法来制备，其中R是 H，-CL，-NO 2，-CH 3或-OCH 3与通式III的巴比妥酸（III）在作为缩合剂的酸存在下，通过在 其中使用的酸性缩合剂是通式IV（IV）的脂族二羧酸，其中R 1是甲基或乙基，R 2是3或4个碳原子的烷基。

公开(公告)号：US06699911B2

公开(公告)日：2004-03-02

申请号：US09954263

申请日：2001-09-18

申请人： Johannes Grimmer ,  Thomas Müller ,  Hansgeorg Ernst

发明人： Johannes Grimmer ,  Thomas Müller ,  Hansgeorg Ernst

IPC分类号： A61K3112

CPC分类号： C07C403/08 ,  C07C2601/16 ,  Y02P20/55

摘要： A process is provided for the preparation of cyclohexene derivatives of general formula I or II: in which the substituents R1 and R2 independently of one another are defined as follows: R1 is R2 is OH or a protective group convertible to a hydroxyl group by hydrolysis; R3 and R4 are hydrogen or C1-C4-alkyl; and R5 is hydrogen or C1-C4-acyl, by the reduction of alkyne compounds of general formula III or IV: in which the substituents R1 and X are as defined above, wherein the reducing agent used is a mixture of zinc and at least one compound B selected from the group consisting of ammonium salts, copper salts and alkali metal and alkaline earth metal salts.

摘要翻译： 提供用于制备通式I或II的环己烯衍生物的方法：其中取代基R 1和R 2彼此独立地定义如下：R 1是R 2是OH或 通过水解可转化为羟基的保护基; R 3和R 4是氢或C 1 -C 4 - 烷基; 和R 5是氢或C 1 -C 4酰基，通过还原通式III或IV的炔化合物：其中取代基R 1和X如上所定义，其中所用的还原剂是 锌和选自铵盐，铜盐和碱金属和碱土金属盐的至少一种化合物B.