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1.发明授权
公开(公告)号：US5881721A
公开(公告)日：1999-03-16
申请号：US880496
申请日：1997-06-23
CPC分类号： B65D83/0409 , A61M15/003
摘要： Apparatus for orienting elongate objects, for example capsules of medicament, comprises a passage for receiving an individual capsule in a preferred orientation, a container for holding a bulk supply of capsules, and a ramp surface which directs a capsule towards the passage when the device is positioned such that the passage extends vertically downwardly from the container. It has been found that by appropriate choice of ramp angle, passage diameter and container diameter there is a high probability that a single capsule will be loaded into the dispensing passage when the apparatus is inverted to place the dispensing passage below the bulk supply. The apparatus is particularly useful in a dry medicament dispensing apparatus comprising, in addition to the orienting apparatus, a chamber for receiving capsules from the dispensing passage, means for piercing the ends of the capsule, and a mouthpiece for drawing air through the capsule and to entrain the medicament.
摘要翻译： 用于定向细长物体的装置，例如药物的胶囊，包括用于以优选取向接收单个胶囊的通道，用于保持大量胶囊供应的容器以及当装置是装置时将胶囊引向通道的斜面 定位成使得通道从容器垂直向下延伸。 已经发现，通过适当地选择斜坡角度，通道直径和容器直径，当装置被倒置以将分配通道放置在批量供应下方时，单个胶囊将被加载到分配通道中的可能性很高。 该装置在干药物分配装置中特别有用，除了定向装置之外，还包括用于从分配通道接收胶囊的腔室，用于刺穿胶囊的端部的装置，以及用于吸入空气通过胶囊的吸嘴，以及 夹带药物。
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公开(公告)号：US08109267B2
公开(公告)日：2012-02-07
申请号：US12299922
申请日：2007-05-11
CPC分类号： A61M15/0045 , A61M15/0021 , A61M15/0048 , A61M15/005 , A61M15/0051 , A61M2202/064
摘要： A dry powder inhaler for pulmonary or nasal use, comprising at least an inhaler body and a cartridge with one or more compartments each containing one dose of a drug. The compartment has holes to admit air and holes to deliver powder, which, in use, communicate with an inhalation channel in the inhaler body. To prevent the powder from leaking through the compartment holes before use, the air admission holes are of reduced dimension, thereby blocking or hindering powder exit under the force of gravity. When the cartridge is inserted inside the inhaler body, all its holes can be blocked. By sliding the cartridge in relation to the body until the inhalation position is reached, the holes come into in fluid communication with one another and with the inhalation channel, thereby allowing a flow of air to disperse and entrain the dose through the mouthpiece. Five embodiments are disclosed.
摘要翻译： 一种用于肺或鼻用的干粉吸入器，至少包括吸入器主体和具有一个或多个隔室的药筒，每个隔室含有一剂药物。 隔间具有孔，以允许空气和空洞输送粉末，其在使用中与吸入器主体中的吸入通道相通。 为了防止粉末在使用前通过隔室孔泄漏，进气孔尺寸减小，从而在重力作用下堵塞或阻碍粉末排出。 当墨盒插入吸入器主体内时，所有的孔都可能被堵塞。 通过相对于本体滑动药筒直到达到吸入位置，这些孔彼此流体连通并且与吸入通道形成流体连通，从而允许空气流分散并夹带剂量通过吸嘴。 公开了五个实施例。
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公开(公告)号：US5673686A
公开(公告)日：1997-10-07
申请号：US382428
申请日：1995-02-02
CPC分类号： A61M15/0028 , A61M15/0038 , A61M2202/064
摘要： A new inhalation device, which during operation causes an aerosol to be formed inside a chamber such as a capsule (4) which occludes one end (3) of the inhalation tube (1), the capsule having holes at its extremities (7,8) which admit airflow. The airflow causes the powder contained inside the capsule to be surprisingly transported to the capsule extremity contrary to the direction of inhalation, that is towards the air entry holes in the capsule, and then to form an aerosol until all powder has been removed from the capsule or chamber through the tube (1), the during of inhalation being chiefly regulated by the size and proportion of the capsule holes. The tube (1) has air inlets downstream of the capsule to permit a balanced airflow that will transport the finely suspended powder into the lungs, maximizing the fraction of medicament deposited therein.
摘要翻译： 一种新的吸入装置，其在操作期间引起气泡形成在诸如封闭吸入管（1）的一端（3）的胶囊（4）的腔室内，所述胶囊在其末端具有孔（7,8 ）允许气流。 气流使得容纳在胶囊内的粉末能够令人惊讶地与吸入方向相反地输送到胶囊末端，即朝向胶囊中的空气进入孔，然后形成气溶胶，直到所有粉末从胶囊中移出 或通过管（1）的腔室，吸入期间主要由胶囊孔的尺寸和比例来调节。 管（1）具有在胶囊下游的空气入口，以允许平衡的气流，其将精细悬浮的粉末输送到肺中，使其中沉积的药物的分数最大化。
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公开(公告)号：US20090178676A1
公开(公告)日：2009-07-16
申请号：US12299922
申请日：2007-05-11
申请人： Peter Villax , Iain McDerment , Martin Bunce
发明人： Peter Villax , Iain McDerment , Martin Bunce
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0021 , A61M15/0048 , A61M15/005 , A61M15/0051 , A61M2202/064
摘要： A dry powder inhaler for pulmonary or nasal use, comprising at least an inhaler body and a cartridge with one or more compartments each containing one dose of a drug. The compartment has holes to admit air and holes to deliver powder, which, in use, communicate with an inhalation channel in the inhaler body. To prevent the powder from leaking through the compartment holes before use, the air admission holes are of reduced dimension, thereby blocking or hindering powder exit under the force of gravity. When the cartridge is inserted inside the inhaler body, all its holes can be blocked. By sliding the cartridge in relation to the body until the inhalation position is reached, the holes come into in fluid communication with one another and with the inhalation channel, thereby allowing a flow of air to disperse and entrain the dose through the mouthpiece. Five embodiments are disclosed.
摘要翻译： 一种用于肺或鼻用的干粉吸入器，至少包括吸入器主体和具有一个或多个隔室的药筒，每个隔室含有一剂药物。 隔间具有孔，以允许空气和空洞输送粉末，其在使用中与吸入器主体中的吸入通道相通。 为了防止粉末在使用前通过隔室孔泄漏，进气孔尺寸减小，从而在重力作用下堵塞或阻碍粉末排出。 当墨盒插入吸入器主体内时，所有的孔都可能被堵塞。 通过相对于本体滑动药筒直到达到吸入位置，这些孔彼此流体连通并且与吸入通道形成流体连通，从而允许空气流分散并夹带剂量通过吸嘴。 公开了五个实施例。
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公开(公告)号：US08677992B2
公开(公告)日：2014-03-25
申请号：US13094108
申请日：2011-04-26
申请人： Peter Villax , Pedro J. Mendes , Iain G. Mcderment
发明人： Peter Villax , Pedro J. Mendes , Iain G. Mcderment
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M11/001 , A61M15/0038 , A61M15/004 , A61M15/0063 , A61M2202/064 , A61M2205/581 , A61M2205/582
摘要： A dry powder inhaler for pulmonary or nasal use, employing capsules containing a dose of powder for inhalation, comprising two operating components and an optional cover. Air is drawn by the patient via a mouthpiece or nosepiece which is in communication with the capsule and travels via air paths through the device and through the capsule thereby dispersing and entraining the dose of powder. The capsule is cut by cutting means located on one of the components, in a manner which eliminates or minimizes capsule debris and minimizes powder leakage during use. The inhaler body and capsule cutting blades comprise a single operating component and they may be manufactured in a single unitary step. The invention affords a very economical and simple device for the delivery of pulmonary medicines.
摘要翻译： 用于肺或鼻用的干粉吸入器，使用含有一定剂量的用于吸入的粉末的胶囊，包括两个操作部件和可选的盖。 空气被患者通过与胶囊连通并且通过空气通道穿过该装置并通过胶囊行进的接口管或鼻梁，从而分散和夹带粉末剂量。 胶囊由位于其中一个部件上的切割装置切割，以消除或最小化胶囊碎屑并使使用中的粉末泄漏最小化的方式。 吸入器主体和胶囊切割刀片包括单个操作部件，并且它们可以以单个单一步骤制造。 本发明提供了用于递送肺部药物的非常经济且简单的装置。
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公开(公告)号：US20110259328A1
公开(公告)日：2011-10-27
申请号：US13094108
申请日：2011-04-26
申请人： Peter Villax , Pedro J. Mendes , Iain G. Mcderment
发明人： Peter Villax , Pedro J. Mendes , Iain G. Mcderment
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M11/001 , A61M15/0038 , A61M15/004 , A61M15/0063 , A61M2202/064 , A61M2205/581 , A61M2205/582
摘要： A dry powder inhaler for pulmonary or nasal use, employing capsules containing a dose of powder for inhalation, comprising two operating components and an optional cover. Air is drawn by the patient via a mouthpiece or nosepiece which is in communication with the capsule and travels via air paths through the device and through the capsule thereby dispersing and entraining the dose of powder. The capsule is cut by cutting means located on one of the components, in a manner which eliminates or minimizes capsule debris and minimizes powder leakage during use. The inhaler body and capsule cutting blades comprise a single operating component and they may be manufactured in a single unitary step. The invention affords a very economical and simple device for the delivery of pulmonary medicines.
摘要翻译： 用于肺或鼻用的干粉吸入器，使用含有一定剂量的用于吸入的粉末的胶囊，包括两个操作部件和可选的盖。 空气被患者通过与胶囊连通并且通过空气通道穿过该装置并通过胶囊行进的接口管或鼻梁，从而分散和夹带粉末剂量。 胶囊由位于其中一个部件上的切割装置切割，以消除或最小化胶囊碎屑并使使用中的粉末泄漏最小化的方式。 吸入器主体和胶囊切割刀片包括单个操作部件，并且它们可以以单个单一步骤制造。 本发明提供了用于递送肺部药物的非常经济且简单的装置。
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