公开(公告)号：US12083264B2

公开(公告)日：2024-09-10

申请号：US17443206

申请日：2021-07-22

申请人： Derek Domenici

发明人： Derek Domenici

IPC分类号： A24F40/42 ,  A24F40/44 ,  A24F40/46 ,  A24F40/48 ,  A24F40/485 ,  A61M11/04 ,  A61M15/00 ,  A24F40/10 ,  A61M15/06

CPC分类号： A61M11/042 ,  A24F40/42 ,  A24F40/44 ,  A24F40/46 ,  A24F40/485 ,  A61M15/0021 ,  A61M15/0025 ,  A61M15/003 ,  A61M15/0036 ,  A24F40/10 ,  A24F40/48 ,  A61M15/06 ,  A61M2205/8206

摘要： Disclosed is an inhalation device which comprises a housing having a removable therein. The vial will contain such liquid as phyto-cannabinoids, cannabidiol, terpenoids, aromatherapy, or tetrahydrocannabinol. A conveyance tube in the housing communicate with the interior of the vial and has therein a material for conveying the distillates by capillary action to a vaporization chamber. The conveyance tube has a conically shaped head for puncturing THC membrane. The liquid in the vial to passes from the conveyance tube into a vaporization chamber. The vaporization chamber, which is also in the housing, has attached to it a heating device for vaporizing the liquid. The vaporized liquid then passes through vents in the vaporization chamber housing and within the main housing so as to be available to be drawn out through a mouthpiece which is in turn secured to the housing.

公开(公告)号：US20240226092A1

公开(公告)日：2024-07-11

申请号：US18529978

申请日：2023-12-05

申请人： MICRONEB TECH HOLDINGS, INC.

发明人： Pradeep Albert ,  Christine Nichols ,  David J. Condron ,  Brian Artze ,  Fadi Saba ,  Jesse Klein ,  Vijay Vad ,  Stephen Naeger

IPC分类号： A61K31/485 ,  A61K9/00 ,  A61K9/08 ,  A61K31/137 ,  A61K31/4164 ,  A61K31/475 ,  A61K47/02 ,  A61M11/00 ,  A61M15/00

CPC分类号： A61K31/485 ,  A61K9/0078 ,  A61K9/08 ,  A61K31/137 ,  A61K31/4164 ,  A61K31/475 ,  A61K47/02 ,  A61M11/00 ,  A61M15/003

摘要： A pharmaceutical composition and method for treating opioid overdose, opioid dependency, and xylazine exposure is disclosed, utilizing an aqueous solution of sodium chloride. This solution contains active ingredients such as naloxone and yohimbine in specific concentrations, with naloxone targeting opioid overdose and yohimbine aimed at counteracting Xylazine effects. In various embodiments, additional components like tolazoline and different buffers can be included. The disclosure introduces a unique delivery system that features a capsule with a vibrating mesh atomizer for efficient administration. Specifically, for yohimbine, a dual-reservoir capsule design facilitates controlled mixing with diluents or buffers. The administration of this pharmaceutical composition can be achieved through multiple methods, including intramuscular, intravenous, and atomized routes. The atomizing device incorporates a removable cap and a resilient air bladder, ensuring effective drug delivery. This system offers precision and adaptability in treating conditions related to opioid overdose, dependency, and Xylazine exposure.

公开(公告)号：US20240122889A1

公开(公告)日：2024-04-18

申请号：US18513377

申请日：2023-11-17

申请人： Insmed Incorporated

发明人： Gerald O’Brien ,  Fraz Ismat ,  Ariel Teper

IPC分类号： A61K31/222 ,  A61K9/00 ,  A61K47/18 ,  A61K47/26 ,  A61M15/00

CPC分类号： A61K31/222 ,  A61K9/0075 ,  A61K47/183 ,  A61K47/26 ,  A61M15/003

摘要： The present disclosure provides dry powder compositions of treprostinil prodrugs and methods of treating pulmonary hypertension (e.g., pulmonary arterial hypertension or PH associated with interstitial lung disease), in a patient in need thereof with the same. The dry powder composition includes (a) from about 0.5 wt % to about 5 wt % of a compound of Formula (I):




a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, (b) from about 10 wt % to about 61 wt % of leucine, and the balance being (c) a sugar selected from the group consisting of trehalose and mannitol. The entirety of (a), (b), and (c) is 100 wt %, and R1 is tetradecyl, pentadecyl, hexadecyl, heptadecyl, or octadecyl. The method of treating PH includes administering an effective amount of the dry powder composition to the lungs of the patient by inhalation via a dry powder inhaler, during an administration period. In certain compositions and methods provided herein, R1 is hexadecyl, e.g., linear hexadecyl.

公开(公告)号：US11951247B2

公开(公告)日：2024-04-09

申请号：US16772083

申请日：2017-12-13

申请人： Emphasys Importadora Exportadora e Distribuidora Ltda.

发明人： Victor Esteve

IPC分类号： A61M15/00

CPC分类号： A61M15/003 ,  A61M15/0026 ,  A61M2202/064

摘要： It is provided a dry powder inhaler (2) for a capsule containing dry powder, the dry powder inhaler (2) comprises: a mouth piece (14) with a mouth portion, wherein an opening of the mouth portion leads into a duct; a one-piece base body (10) comprising a capsule chamber portion and being attached to a covering body (6); and an actuator button (8) movable relative to the one-piece base body (10) from a normal position to a perforation position along an actuation direction, wherein the actuation direction is perpendicular to the longitudinal axis, and wherein perforation needles attached to the actuator button (8) extend into the capsule chamber when the actuator button (8) is in the perforation position.

公开(公告)号：US11825878B2

公开(公告)日：2023-11-28

申请号：US16851791

申请日：2020-04-17

申请人： Altria Client Services LLC

发明人： Yossef Raichman

IPC分类号： A24F40/42 ,  A61M15/06 ,  A61M15/00 ,  A61M11/04 ,  G05D23/19 ,  A24F40/46 ,  A24F40/51 ,  A24F40/05 ,  A24F40/57 ,  A24F40/40 ,  A61M16/00 ,  A24F40/20

CPC分类号： A24F40/42 ,  A24F40/05 ,  A24F40/40 ,  A24F40/46 ,  A24F40/51 ,  A24F40/57 ,  A61M11/042 ,  A61M11/044 ,  A61M15/003 ,  A61M15/0063 ,  A61M15/0085 ,  A61M15/06 ,  G05D23/1904 ,  A24F40/20 ,  A61M2016/0021 ,  A61M2016/0039 ,  A61M2205/3368 ,  A61M2205/3653 ,  A61M2205/8206

摘要： Apparatus and methods are described for use with a vaporizer that vaporizes at least one active ingredient of a plant material. In response to receiving a first input to the vaporizer, the plant material is heated, in a first heating step. An indication of the temperature of the plant material is detected, and, in response to detecting an indication that the temperature of the plant material is at a first temperature, the first heating step is terminated, by withholding causing further temperature increase of the plant material. The first temperature is less than 95 percent of the vaporization temperature of the active ingredient. Subsequently, a second input is received at the vaporizer. In response thereto, the plant material is heated to the vaporization temperature, in a second heating step. Other applications are also described.

公开(公告)号：US20230347082A1

公开(公告)日：2023-11-02

申请号：US18349477

申请日：2023-07-10

申请人： Altria Client Services LLC

发明人： Yossef RAICHMAN

IPC分类号： A61M15/06 ,  A61M15/00 ,  A61K36/185 ,  G05D23/19 ,  A61K9/00 ,  A61M11/04 ,  A24F40/51 ,  A24F40/53

CPC分类号： A61M15/06 ,  A61M15/003 ,  A61M15/0085 ,  A61K36/185 ,  G05D23/1904 ,  A61K9/007 ,  A61M11/042 ,  A61M15/0003 ,  A24F40/51 ,  A24F40/53 ,  G05D23/1927 ,  A61M2205/3313 ,  A61M2205/3368 ,  A61M2205/3653 ,  A61M15/0063 ,  A61M2205/3317 ,  A61M2205/8206 ,  A24F40/20

摘要： Apparatus and methods are described for use with a vaporizer that vaporizes at least one active ingredient of a material. In response to receiving a first input to the vaporizer, the material is heated, in a first heating step. An indication of the temperature of the material is detected, and, in response to detecting an indication that the temperature of the material is at a first temperature, the first heating step is terminated, by withholding causing further temperature increase of the material. The first temperature is less than 95 percent of the vaporization temperature of the active ingredient. Subsequently, a second input is received at the vaporizer. In response thereto, the material is heated to the vaporization temperature, in a second heating step. Other applications are also described.

公开(公告)号：US20230346023A1

公开(公告)日：2023-11-02

申请号：US18348529

申请日：2023-07-07

申请人： Altria Client Services LLC

发明人： Yossef RAICHMAN

IPC分类号： A24F40/42 ,  A24F40/46 ,  A24F40/40 ,  A24F40/57 ,  A24F40/50 ,  A61M11/04 ,  A61M15/00 ,  A61P25/36 ,  A61P27/06 ,  A61P25/30 ,  A61P43/00 ,  A61P11/06 ,  A61P25/18 ,  A61P25/08 ,  A61P29/00 ,  A61P1/08 ,  A61K9/00 ,  A61K31/05 ,  A61K31/352 ,  A61K36/185 ,  A61M15/06

CPC分类号： A24F40/42 ,  A24F40/46 ,  A24F40/40 ,  A24F40/57 ,  A24F40/50 ,  A61M11/042 ,  A61M15/00 ,  A61M15/003 ,  A61P25/36 ,  A61P27/06 ,  A61P25/30 ,  A61P43/00 ,  A61P11/06 ,  A61P25/18 ,  A61P25/08 ,  A61P29/00 ,  A61P1/08 ,  A61K9/007 ,  A61K31/05 ,  A61K31/352 ,  A61K36/185 ,  A61M15/06 ,  A24F40/20

摘要： The method includes first heating at least one plant material within a first target temperature range for one or more first durations of time, the at least one plant material including at least one constituent compound, and second heating the at least one plant material within a second target temperature range for one or more second durations of time, the second heating causing at least a partial vaporization of the at least one constituent compound, the second target temperature range being greater than the first target temperature range.

公开(公告)号：US20230270953A1

公开(公告)日：2023-08-31

申请号：US18024083

申请日：2021-08-31

申请人： JANSSEN PHARMACEUTICA NV

发明人： Emma Louise HUBERT

IPC分类号： A61M11/00 ,  A61M15/00

CPC分类号： A61M11/007 ,  A61M15/003 ,  A61M2206/16

摘要： Various exemplary drug delivery devices with a spinning nozzle, drug products utilizing the same, and methods of using drug delivery devices with a spinning nozzle are provided. In general, a nasal drug delivery device configured to dispense a drug therefrom includes a spinning nozzle configured to facilitate the drug's ejection into a patient's nose. The spinning nozzle is located between a drug holder containing the drug to be dispensed and an opening of the drug delivery device through which the drug exits the drug delivery device. The spinning nozzle is configured to spin during the drug's delivery as the drug travels from the drug holder and out of the drug delivery device. The spinning nozzle includes a plurality of perforations therein through which the drug as a liquid is configured to pass. The spinning of the spinning nozzle causes the drug to exit the drug delivery device as a fine mist.

公开(公告)号：US20190240150A1

公开(公告)日：2019-08-08

申请号：US16240653

申请日：2019-01-04

申请人： Impel Neuropharma, Inc.

发明人： John D. Hoekman ,  Kelsey H. Satterly ,  Inna Dashevsky ,  Aditya R. Das

IPC分类号： A61K9/00 ,  A61K31/5513 ,  A61K9/16 ,  A61M15/00

CPC分类号： A61K9/0043 ,  A61K9/00 ,  A61K9/16 ,  A61K9/1617 ,  A61K9/1652 ,  A61K31/00 ,  A61K31/5513 ,  A61K47/00 ,  A61M15/003 ,  A61P25/18

摘要： Methods are provided for acute treatment of agitation, including agitation in patients with schizophrenia or bipolar disorder, comprising administering to a subject with agitation an effective dose of a dry pharmaceutical composition comprising olanzapine, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma olanzapine concentration (Cmax) of at least 30 ng/mL, with (b) a mean time to Cmax (Tmax) of olanzapine of less than 0.5 hours. Dry pharmaceutical compositions and devices suitable for intranasal delivery of olanzapine are provided.

公开(公告)号：US20180311156A1

公开(公告)日：2018-11-01

申请号：US15703934

申请日：2017-09-13

申请人： OTITOPIC INC.

发明人： Kambiz YADIDI

IPC分类号： A61K9/00 ,  A61M15/00

CPC分类号： A61K9/0075 ,  A61M11/003 ,  A61M15/0008 ,  A61M15/002 ,  A61M15/0021 ,  A61M15/003 ,  A61M15/0045 ,  A61M15/0068 ,  A61M15/0096 ,  A61M2202/064 ,  A61M2205/43

摘要： Delivery of a dry powder via inhalation can be performed using an inhalation device having an inhalation tube and a hollow extension housing an assembly of components including a plurality of impellers, a puncturing device, and a dry powder container. The delivery of dry powder through the inhalation device is facilitated by the puncturing device puncturing the dry powder container, the impellers directing air flow, and the configuration of the extension and inhalation tube.