公开(公告)号：US06217887B1

公开(公告)日：2001-04-17

申请号：US09323531

申请日：1999-06-01

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken Schuette ,  Raymond Wei Chen

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken Schuette ,  Raymond Wei Chen

IPC分类号： A61K600

CPC分类号： A61K8/365 ,  A61K8/347 ,  A61K8/463 ,  A61Q17/005 ,  A61Q19/00 ,  Y10S514/846 ,  Y10S514/859 ,  Y10S514/941 ,  Y10S514/942

摘要： The present invention relates to a leave-on antimicrobial composition comprising from about 0.001% to about 5% of an antimicrobial active; from about 0.5% to about 10% of an anionic surfactant; from about 0.1% to about 10% of a proton donating agent, wherein the proton donating agent is such that the composition is essentially free of C4-C20 alkyl fatty acid; and from about 0% to about 98.85% of water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the leave-on antimicrobial composition has a One-wash Immediate Germ Reduction Index of greater than about 50%; and wherein the leave-on antimicrobial composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for moisturizing skin, reducing germs on the skin, and providing residual effectiveness versus Gram positive bacteria using these products.

摘要翻译： 本发明涉及一种留下抗微生物组合物，其包含约0.001％至约5％的抗微生物活性物质; 约0.5％至约10％的阴离子表面活性剂; 约0.1％至约10％的质子供体剂，其中质子供体剂使得组合物基本上不含C 4 -C 20烷基脂肪酸; 和约0％至约98.85％的水; 其中将组合物调节至约3.0至约6.0的pH; 其中所述留下的抗微生物组合物具有大于约50％的一次洗涤立即灭菌指数; 并且其中所述留置的抗微生物组合物具有大于0.3的温和指数。 本发明还包括用于保湿皮肤，减少皮肤上的细菌并且使用这些产品对革兰氏阳性细菌提供残留效力的方法。

公开(公告)号：US06488943B1

公开(公告)日：2002-12-03

申请号：US09535250

申请日：2000-03-27

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken Schuette ,  Raymond Wei Cen

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken Schuette ,  Raymond Wei Cen

IPC分类号： A61K900

CPC分类号： C11D3/48 ,  A01N31/16 ,  C11D1/02 ,  C11D3/2075 ,  C11D3/28 ,  C11D17/049 ,  A01N2300/00 ,  A01N43/36 ,  A01N37/36 ,  A01N37/04 ,  A01N37/02 ,  A01N31/06 ,  A01N25/34 ,  A01N25/30

摘要： The present invention relates to an antimicrobial wipe effective against Gram positive bacteria, Gram negative bacteria, fungi, yeasts, molds, and viruses comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the antimicrobial cleansing composition an One-wash Immediate Germ Reduction Index of greater than about 1.3; and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The present invention also relates to methods for removing germs from the skin using the antimicrobial wipes described herein.

摘要翻译： 本发明涉及对抗革兰氏阳性细菌，革兰氏阴性细菌，真菌，酵母，霉菌和病毒的抗微生物擦拭物，其包含浸渍有抗微生物清洁组合物的多孔或吸收性片材，其中所述抗微生物清洁组合物包含约0.001％至 约5.0％的抗微生物清洁组合物;抗微生物活性物质; 约0.05％至约10％的抗微生物清洁组合物;阴离子表面活性剂; 约0.1重量％至约10重量％的抗微生物清洁组合物;质子供体剂; 和约3％至约99.85％的抗微生物清洁组合物，水; 其中将组合物调节至约3.0至约6.0的pH; 其中所述抗微生物清洁组合物具有大于约1.3的单洗立即生物降解指数; 并且其中所述洗涤抗微生物清洁组合物具有大于0.3的温和指数。 本发明还涉及使用本文所述的抗微生物擦拭剂从皮肤除去细菌的方法。

公开(公告)号：US06482423B1

公开(公告)日：2002-11-19

申请号：US09534732

申请日：2000-03-27

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken Schuette ,  Raymond Wei Cen ,  Mannie Lee Clapp ,  Raphael Warren

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken Schuette ,  Raymond Wei Cen ,  Mannie Lee Clapp ,  Raphael Warren

IPC分类号： A61K600

CPC分类号： A61Q17/005 ,  A61K8/0208 ,  A61K8/347 ,  A61K8/42 ,  A61K8/4913 ,  A61K8/4926 ,  A61K8/4933 ,  A61K8/92 ,  A61K8/922 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q19/10 ,  C11D1/02 ,  C11D3/2075 ,  C11D3/28 ,  C11D3/48 ,  C11D17/049

摘要： The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the antimicrobial cleansing composition has a Gram Positive Residual Effectiveness Index of greater than about 0.5; and wherein the antimicrobial cleansing composition has a Mildness Index of less than about 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.

摘要翻译： 本发明涉及一种抗微生物擦拭物，其包括浸渍有抗微生物清洁组合物的多孔或吸收性片材，其中所述抗微生物清洁组合物包含抗微生物清洁组合物的约0.001％至约5.0％的抗微生物活性成分; 约0.05％至约10％的抗微生物清洁组合物;阴离子表面活性剂; 约0.1重量％至约10重量％的抗微生物清洁组合物;质子供体剂; 和约3％至约99.85％的抗微生物清洁组合物，水; 其中将组合物调节至约3.0至约6.0的pH; 其中所述抗微生物清洁组合物具有大于约0.5的革兰氏阳性残留有效性指数; 并且其中所述抗微生物清洁组合物的温和指数小于约0.3。 本发明还包括使用这些产品的用于清洁皮肤并提供残留效力的革兰氏阳性细菌的方法。

公开(公告)号：US06451333B1

公开(公告)日：2002-09-17

申请号：US09323419

申请日：1999-06-01

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Robert Gregory Bartolo ,  Theresa Anne Bakken Schuette

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Robert Gregory Bartolo ,  Theresa Anne Bakken Schuette

IPC分类号： A01N2500

CPC分类号： A61Q19/00 ,  A61K8/347 ,  A61K8/365 ,  A61K8/368 ,  A61K8/463 ,  A61K8/466 ,  A61K8/4933 ,  A61Q5/02 ,  A61Q17/005 ,  A61Q19/10 ,  C11D1/37 ,  C11D3/042 ,  C11D3/2034 ,  C11D3/2075 ,  C11D3/3773 ,  C11D3/48 ,  Y10S514/975

摘要： The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.1% to about 5.0%, by weight of the cleansing composition, of an antimicrobial active; from about 9% to about 14%, by weight of the cleansing composition, of an anionic surfactant, wherein at least about 67% of the anionic surfactant is selected from the group consisting of Class A surfactants, Class C surfactants, and mixtures thereof, wherein the ratio of Class A surfactant to Class C is from about 4:1 to about 1.5:1, and wherein the total anionic surfactant comprises less than about 50% of the ammonium counter cation salt; from about 4% to about 8%, by weight of the cleansing composition, of a proton donating agent having a Biological Activity Index, Z, of greater than about 0.75 and wherein the proton donating agent is such that the composition is essentially free of C4-C20 alkyl fatty acid; a mildness enhancing agent selected from the group consisting of from about 20% to about 70%, by weight of the anionic surfactant, of a mildness enhancing cosurfactant; form about 0.1% to about 1.0%, by weight of the cleansing composition, of a mildness enhancing polymer; and mixtures thereof; and from about 35% to about 93.9%, by weight of the cleansing composition, of water; wherein the composition is adjusted to a pH of greater than about 3.5 and less than about 4.5. The invention also encompasses methods for cleansing, removing germs and decreasing the spread of transient Gram negative and Gram positive bacteria using the rinse-off antimicrobial cleansing compositions described herein.

摘要翻译： 本发明涉及一种洗涤抗微生物清洁组合物，其包含按重量计约0.1％至约5.0％的清洁组合物的抗微生物活性物质; 约9％至约14％的所述清洁组合物的阴离子表面活性剂，其中至少约67％的阴离子表面活性剂选自A类表面活性剂，C类表面活性剂及其混合物， 其中A类表面活性剂与C类的比例为约4:1至约1.5:1，并且其中总阴离子表面活性剂包含小于约50％的铵抗衡阳离子盐; 约4％至约8％的清洁组合物，具有大于约0.75的生物活性指数Z的质子供体，其中质子供体剂使得组合物基本上不含C4 -C 20烷基脂肪酸; 选自按重量计约20％至约70％的阴离子表面活性剂的温和增强助剂，具有温和增强助表面活性剂; 形成约0.1重量％至约1.0重量％的清洁组合物;增温聚合物; 及其混合物; 和约35％至约93.9％（重量）的清洁组合物; 其中将组合物调节至大于约3.5且小于约4.5的pH。 本发明还包括使用本文所述的冲洗性抗微生物清洁组合物清洁，去除细菌并减少瞬时革兰氏阴性和革兰氏阳性细菌的扩散的方法。

公开(公告)号：US06413529B1

公开(公告)日：2002-07-02

申请号：US09536314

申请日：2000-03-27

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Raymond Wei Cen ,  Theresa Anne Bakken Schuette

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Raymond Wei Cen ,  Theresa Anne Bakken Schuette

IPC分类号： A01N2534

CPC分类号： A61Q17/005 ,  A61K8/0208 ,  A61K8/347 ,  A61K8/463 ,  A61K8/466 ,  A61K8/4913 ,  A61Q19/10 ,  C11D1/02 ,  C11D3/2075 ,  C11D3/28 ,  C11D3/48 ,  C11D17/049

摘要： The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the antimicrobial cleansing composition has a Gram Negative Residual Effectiveness Index of greater than about 0.3. The invention also relates to these antibacterial wipes wherein the antimicrobial cleansing composition has a Mildness Index of greater than about 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.

摘要翻译： 本发明涉及一种抗微生物擦拭物，其包括浸渍有抗微生物清洁组合物的多孔或吸收性片材，其中所述抗微生物清洁组合物包含抗微生物清洁组合物的约0.001％至约5.0％的抗微生物活性成分; 约0.05％至约10％的抗微生物清洁组合物;阴离子表面活性剂; 约0.1重量％至约10重量％的抗微生物清洁组合物;质子供体剂; 和约3％至约99.85％的抗微生物清洁组合物，水; 其中将组合物调节至约3.0至约6.0的pH; 其中所述抗微生物清洁组合物具有大于约0.3的革兰氏阴性残留有效性指数。 本发明还涉及这些抗菌擦拭物，其中抗微生物清洁组合物的温和指数大于约0.3。 本发明还包括使用这些产品的用于清洁皮肤并提供与革兰氏阴性细菌的残留效力的方法。

公开(公告)号：US6113933A

公开(公告)日：2000-09-05

申请号：US323513

申请日：1999-06-01

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Robert Gregory Bartolo ,  Theresa Anne Bakken Schuette

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Robert Gregory Bartolo ,  Theresa Anne Bakken Schuette

IPC分类号： A61K8/00 ,  A01N25/30 ,  A01N25/34 ,  A61K20060101 ,  A61K8/49 ,  A61K8/58 ,  A61Q5/02 ,  A61Q19/10 ,  C11D20060101 ,  C11D1/02 ,  C11D3/00 ,  C11D3/48 ,  A61K7/40 ,  A61K7/50

CPC分类号： A61Q17/005 ,  A61K8/347 ,  A61K8/442 ,  A61K8/463 ,  A61K8/466 ,  A61Q19/10 ,  A61K2800/596 ,  A61Q5/02 ,  Y10S514/975

摘要： The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.1% to about 5.0%, by weight of the cleansing composition, of an antimicrobial active; from about 4% to about 18%, by weight of the cleansing composition, of an anionic surfactant, wherein at least about 67% of the anionic surfactant is selected from the group consisting of Class A surfactants, Class C surfactants, and mixtures thereof, wherein the ratio of Class A surfactant to Class C is from about 100:0 to about 1.5:1; from about 0.1% to about 10%, by weight of the cleansing composition, of a Class D acidic surfactants; from 0.1% to about 8%, by weight of the cleansing composition, of a proton donating agent having a Biological Activity Index, Z, of greater than about 0.75, and wherein the proton donating agent is such that the composition is essentially free of C.sub.4 -C.sub.20 alkyl fatty acid; from about 67.0% to about 95.8%, by weight of the cleansing composition, of water; wherein the composition is adjusted to a pH of greater than about 3.0 and less than about 5.5; and wherein the ratio of the amount of non-anionic surfactants to the amount of anionic surfactant is less than 1:1. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.

摘要翻译： 本发明涉及一种洗涤抗微生物清洁组合物，其包含按重量计约0.1％至约5.0％的清洁组合物的抗微生物活性物质; 约4％至约18％的所述清洁组合物的阴离子表面活性剂，其中至少约67％的阴离子表面活性剂选自A类表面活性剂，C类表面活性剂及其混合物， 其中A类表面活性剂与C类的比例为约100：0至约1.5：1; 约0.1％至约10％的清洁组合物; D类酸性表面活性剂; 0.1重量％至约8重量％的清洁组合物，具有大于约0.75的生物活性指数Z的质子供体试剂，其中质子供体剂使得组合物基本上不含C4 -C 20烷基脂肪酸; 约为洗涤组合物重量的约67.0％至约95.8％的水; 其中将所述组合物调节至大于约3.0且小于约5.5的pH; 并且其中非阴离子表面活性剂的量与阴离子表面活性剂的量的比率小于1:1。 本发明还包括使用这些产品的用于清洁皮肤并提供与革兰氏阴性细菌的残留效力的方法。

公开(公告)号：US6106851A

公开(公告)日：2000-08-22

申请号：US323420

申请日：1999-06-01

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Robert Gregory Bartolo ,  Theresa Anne Bakken Schuette

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Robert Gregory Bartolo ,  Theresa Anne Bakken Schuette

IPC分类号： A61K8/00 ,  A61K8/33 ,  A61K8/49 ,  A61K8/58 ,  A61Q5/02 ,  A61Q19/10 ,  C11D1/02 ,  C11D3/20 ,  C11D3/24 ,  C11D3/28 ,  C11D3/32 ,  C11D3/48 ,  A61K6/00 ,  A61K7/075 ,  A61K7/40 ,  A61K31/05 ,  A61K31/075

CPC分类号： A61Q17/005 ,  A61K8/347 ,  A61K8/442 ,  A61K8/463 ,  A61K8/466 ,  A61Q19/10 ,  C11D3/2086 ,  C11D3/24 ,  C11D3/28 ,  C11D3/323 ,  C11D3/48 ,  A61K2800/596 ,  A61Q5/02 ,  C11D1/02 ,  Y10S514/846 ,  Y10S514/859 ,  Y10S514/941 ,  Y10S514/942

摘要： The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.1% to about 5.0%, by weight of the cleansing composition, of an antimicrobial active; from about 6% to about 16%, by weight of the cleansing composition, of an anionic surfactant, wherein at least about 67% of the anionic surfactant is selected from the group consisting of Class A surfactants, Class C surfactants, and mixtures thereof, wherein the ratio of Class A surfactant to Class C is from about 100:0 to about 1.5:1; from about 2% to about 4%, by weight of the cleansing composition, of a proton donating agent having a Biological Activity Index, Z, of greater than about 0.75, wherein the proton donating agent is such that the composition is essentially free of C.sub.4 -C.sub.20 alkyl fatty acid, and wherein from about 0.15% to about 2%, by weight of the cleansing composition, of the proton donating agent is salicylic acid; a mildness enhancing agent selected from the group consisting of from about 20% to about 70%, by weight of the anionic surfactant, of a mildness enhancing cosurfactant; from about 0.1% to about 1.0%, by weight of the cleansing composition, of a mildness enhancing polymer; and mixtures thereof, and from about 35% to about 95.75%, by weight of the cleansing composition, of water; wherein the composition is adjusted to a pH of greater than about 3 and less than about 6. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.

摘要翻译： 本发明涉及一种洗涤抗微生物清洁组合物，其包含按重量计约0.1％至约5.0％的清洁组合物的抗微生物活性物质; 约6％至约16％的洗涤组合物的阴离子表面活性剂，其中至少约67％的阴离子表面活性剂选自A类表面活性剂，C类表面活性剂及其混合物， 其中A类表面活性剂与C类的比例为约100：0至约1.5：1; 约2％至约4％的清洁组合物，具有大于约0.75的生物活性指数Z的质子供体，其中质子供体剂使得组合物基本上不含C4 -C 20烷基脂肪酸，其中约0.15重量％至约2重量％的所述清洁组合物的质子供体剂为水杨酸; 选自按重量计约20％至约70％的阴离子表面活性剂的温和增强助剂，具有温和增强助表面活性剂; 约0.1％至约1.0％的所述清洁组合物;增温聚合物; 和它们的混合物，和约35％至约95.75％重量的清洁组合物; 其中将组合物调节至大于约3且小于约6的pH。本发明还包括使用这些产品对革兰氏阴性细菌进行清洁皮肤并提供残留效力的方法。

公开(公告)号：US06258368B1

公开(公告)日：2001-07-10

申请号：US08868717

申请日：1997-06-04

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken ,  Marcus Wayne Evans

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken ,  Marcus Wayne Evans

IPC分类号： A01N2500

CPC分类号： A61Q17/005 ,  A61K8/0208 ,  C11D1/37 ,  C11D3/042 ,  C11D3/2034 ,  C11D3/2075 ,  C11D3/3769 ,  C11D3/48 ,  C11D17/049

摘要： The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0. The invention also encompasses methods for cleansing skin, reducing the number of germs on the skin, and providing residual effectiveness versus Gram positive and Gram negative bacteria using these products.

摘要翻译： 本发明涉及一种抗微生物擦拭物，其包括浸渍有抗微生物清洁组合物的多孔或吸收性片材，其中所述抗微生物清洁组合物包含抗微生物清洁组合物的约0.001％至约5.0％的抗微生物活性成分; 约0.05％至约10％的抗微生物清洁组合物;阴离子表面活性剂; 约0.1重量％至约10重量％的抗微生物清洁组合物;质子供体剂; 和约3％至约99.85％的抗微生物清洁组合物，水; 其中将组合物调节至约3.0至约6.0的pH。 本发明还包括用于清洁皮肤的方法，减少皮肤上的细菌数量，以及使用这些产品对革兰氏阳性和革兰氏阴性菌提供残留效力。

公开(公告)号：US06210695B1

公开(公告)日：2001-04-03

申请号：US08869129

申请日：1997-06-04

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken ,  Marcus Wayne Evans

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken ,  Marcus Wayne Evans

IPC分类号： A01N2534

CPC分类号： A61Q17/005 ,  A61K8/347 ,  A61K8/368 ,  A61K8/463 ,  A61K8/466 ,  A61Q19/00

摘要： The present invention relates to a leave-on antimicrobial composition comprising from about 0.001% to about 5.0%, by weight of the leave-on antimicrobial composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the leave-on antimicrobial composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the leave-on antimicrobial composition, of a proton donating agent; and from about 0% to about 99.85%, by weight of the leave-on antimicrobial composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0. The invention also encompasses methods for moisturizing, reducing the number of germs on the skin, and decreasing the spread of transient Gram negative and Gram positive bacteria using the leave-on antimicrobial compositions described herein.

摘要翻译： 本发明涉及一种留下的抗微生物组合物，其包含约0.001％至约5.0％（重量）的所述免疫抗微生物组合物，抗微生物活性物质; 约0.05％至约10％的剩余抗微生物组合物;阴离子表面活性剂; 约0.1％至约10％重量的留置抗微生物组合物;质子供体剂; 和约0％至约99.85％（重量）的剩余抗微生物组合物，水; 其中将组合物调节至约3.0至约6.0的pH。 本发明还包括使用本文所述的留下的抗微生物组合物来保湿，减少皮肤上的细菌数量以及减少瞬时革兰氏阴性和革兰氏阳性细菌的扩散的方法。

公开(公告)号：US5968539A

公开(公告)日：1999-10-19

申请号：US868783

申请日：1997-06-04

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Wei Cen ,  Theresa Anne Bakken

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Wei Cen ,  Theresa Anne Bakken

IPC分类号： A01N25/00 ,  A61K8/34 ,  A61K8/36 ,  A61K8/362 ,  A61K8/365 ,  A61K8/368 ,  A61K8/42 ,  A61K8/49 ,  A61Q5/02 ,  A61Q17/00 ,  A61Q19/10 ,  C11D3/20

CPC分类号： A61K8/365 ,  A61K8/347 ,  A61K8/36 ,  A61K8/362 ,  A61K8/368 ,  A61K8/42 ,  A61K8/4926 ,  A61K8/4933 ,  A61Q17/005 ,  A61Q19/10 ,  A61Q5/02

摘要： The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.001% to about 5% of an antimicrobial active, from about 1% to about 80% of an anionic surfactant, from about 0.1% to about 12% of a proton donating agent; and from about 3% to about 98.899% of water, wherein the composition is adjusted to a pH of from about 3.0 to about 6.0, wherein the rinse-off antimicrobial cleansing composition has a Gram Negative Residual Effectiveness Index of greater than about 0.3, and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.

摘要翻译： 本发明涉及一种漂洗抗微生物清洁组合物，其包含约0.001％至约5％的抗微生物活性剂，约1％至约80％的阴离子表面活性剂，约0.1％至约12％的质子 捐赠代理人 和约3％至约98.899％的水，其中将组合物调节至约3.0至约6.0的pH，其中冲洗抗微生物清洁组合物具有大于约0.3的革兰氏阴性残留有效性指数，以及 其中所述洗涤抗微生物清洁组合物的温和指数大于0.3。 本发明还包括使用这些产品的用于清洁皮肤并提供与革兰氏阴性细菌的残留效力的方法。