-
1.发明申请Method for Recognizing Acute Generalized Inflammatory Conditions (Sirs), Sepsis, Sepsis-Like Conditions and Systemic Infections 审中-公开识别急性广泛性炎症病症（Sirs）的方法，败血症，脓毒症状况及全身感染公开(公告)号：US20080070235A1
公开(公告)日：2008-03-20
申请号：US10551874
申请日：2004-03-31
申请人： Stefan Russwurm , Konrad Reinhart , Hans-Peter Saluz , Eberhard Straube , Peter Zipfel , Hans-Peter Deigner
发明人： Stefan Russwurm , Konrad Reinhart , Hans-Peter Saluz , Eberhard Straube , Peter Zipfel , Hans-Peter Deigner
CPC分类号： C12Q1/6883 , B82Y5/00 , B82Y10/00 , C12Q1/6837 , C12Q2600/158 , Y10T436/143333
摘要： The present invention relates to a method for in vitro detection of SIRS, sepsis and/or sepsis-like conditions. This method renders the evaluation of the severity and/or the therapeutic progress of sepsis and severe infections, in particular sepsis-like systemic infections possible. Further, the present invention relates to the use of recombinantly or synthetically prepared nucleic acid sequences or peptide sequences derived therefrom as calibrator in sepsis assays and/or for the evaluation of the effect and the toxicity during screening of the active agents and/or the preparation of therapeutics for the prevention and treatment of SIRS, sepsis, sepsis-like systemic inflammatory conditions and sepsis-like systemic infections.
摘要翻译： 本发明涉及一种用于体外检测SIRS，败血症和/或脓毒病样条件的方法。 该方法可以评估败血症和严重感染的严重性和/或治疗进展，特别是脓毒症样全身感染。 此外，本发明涉及重组或合成制备的核酸序列或其衍生的肽序列作为脓毒症测定中的校准物和/或用于评估活性剂和/或制剂筛选过程中的作用和毒性的用途 用于预防和治疗SIRS，败血症，败血症样全身性炎症病症和败血症样全身感染的治疗剂。
-
2.发明申请公开(公告)号：US20060134685A1
公开(公告)日：2006-06-22
申请号：US11349387
申请日：2006-02-06
CPC分类号： C12Q1/6837
摘要： The application relates to the use of a nucleic acid and/or protein chip comprising probe nucleic acids and/or probe proteins, which are specific for cellular stress, inflammatory and immune reactions, associated with stress, inflammatory and immune reactions, induced during acute phase responses or any combination thereof and which are immobilised on a carrier for the diagnosis of sepsis or sepsis related syndrome.
摘要翻译： 本申请涉及包含探针核酸和/或探针蛋白的核酸和/或蛋白质芯片在与急性期诱导的应激，炎症和免疫反应相关的细胞应激，炎性和免疫反应特异性的应用 反应或其任何组合，并且其固定在用于诊断败血症或败血症相关综合征的载体上。
-
3.发明申请USE OF GENE ACTIVITY CLASSIFIERS FOR THE IN VITRO CLASSIFICATION OF GENE EXPRESSION PROFILES OF PATIENTS WITH INFECTIOUS/NON-INFECTIOUS MULTIPLE ORGAN FAILURE 失效基因活性分类器在感染性/非感染性多器官功能障碍患者基因表达谱分析中的应用公开(公告)号：US20090325152A1
公开(公告)日：2009-12-31
申请号：US11909372
申请日：2006-03-16
申请人： Stefan Russwurm , Konrad Reinhart
发明人： Stefan Russwurm , Konrad Reinhart
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158
摘要： The present invention relates to the use of gene activity markers for classification of patients suffering from infectious and non-infectious multiple organ failure, respectively.The present invention in particular relates to gene activity markers for classification of patients as “not infected without multiple organ failure” or as “not suffering from infectious multiple organ failure” or as “suffering from infectious multiple organ failure”, the gene activity markers being polynucleotides selected from the group consisting of: SEQ ID 1.1, SEQ ID 1.2, SEQ ID 1.3, SEQ ID 1.4, SEQ ID 1.5, SEQ ID 1.6, SEQ ID 1.7, SEQ ID 1.8 and SEQ ID 1.9 or partial sequences thereof.
摘要翻译： 本发明涉及基因活性标记物在分别感染和非感染性多器官功能衰竭患者分类中的应用。 本发明特别涉及将患者分类为“未感染无多器官功能衰竭”或“不患有感染性多器官功能衰竭”或“感染性多器官衰竭患者”的基因活性标志物，所述基因活性标记为 选自SEQ ID No.11，SEQ ID 1.2，SEQ ID 1.3，SEQ ID 1.4，SEQ ID 1.5，SEQ ID 1.6，SEQ ID 1.7，SEQ ID 1.8和SEQ ID.1.9的多核苷酸或其部分序列。
-
4.发明申请METHOD FOR ESTABLISHING THE SOURCE OF INFECTION IN A CASE OF FEVER OF UNCLEAR AETIOLOGY 审中-公开用于建立感染发生源的方法在不明原因感染的病例中公开(公告)号：US20150376698A1
公开(公告)日：2015-12-31
申请号：US14711720
申请日：2015-05-13
申请人： Stefan Russwurm , Konrad Reinhart , Michael Bauer
发明人： Stefan Russwurm , Konrad Reinhart , Michael Bauer
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： Use of gene expression profiles obtained in vitro from a patient's sample for establishing the local infection of a “fever of unknown origin”, wherein the gene expression profiles are specific for local inflammations of a “fever of unknown origin”, such as peritonitis, pneumonia, endocarditis or infections of the urea tract.
摘要翻译： 使用从患者样品体外获得的基因表达谱，以建立“未知来源的发热”的局部感染，其中基因表达谱对于“不明来源的发热”的局部炎症是特异性的，例如腹膜炎，肺炎 ，心内膜炎或尿道感染。
-
5.发明授权Use of gene activity classifiers for the in vitro classification of gene expression profiles of patients with infectious/non-infectious multiple organ failure 失效使用基因活性分类器进行传染性/非感染性多器官功能衰竭患者基因表达谱的体外分类公开(公告)号：US08236496B2
公开(公告)日：2012-08-07
申请号：US11909372
申请日：2006-03-16
申请人： Stefan Russwurm , Konrad Reinhart
发明人： Stefan Russwurm , Konrad Reinhart
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158
摘要： The present invention relates to the use of gene activity markers for classification of patients suffering from infectious and non-infectious multiple organ failure, respectively.The present invention in particular relates to gene activity markers for classification of patients as “not infected without multiple organ failure” or as “not suffering from infectious multiple organ failure” or as “suffering from infectious multiple organ failure”, the gene activity markers being polynucleotides selected from the group consisting of: SEQ ID I.1, SEQ ID I.2, SEQ ID I.3, SEQ ID I.4, SEQ ID I.5, SEQ ID I.6, SEQ ID I.7, SEQ ID I.8 and SEQ ID I.9 or partial sequences thereof.
摘要翻译： 本发明涉及基因活性标记物在分别感染和非感染性多器官功能衰竭患者分类中的应用。 本发明特别涉及将患者分类为“未感染无多器官功能衰竭”或“不患有感染性多器官功能衰竭”或“感染性多器官衰竭患者”的基因活性标志物，所述基因活性标记为 选自SEQ ID I.1，SEQ ID I.2，SEQ ID I.3，SEQ ID I.4，SEQ ID I.5，SEQ ID I.6，SEQ ID I.7， SEQ ID I.8和SEQ ID I.9或其部分序列。
-
6.发明申请METHOD FOR ESTABLISHING THE SOURCE OF INFECTION IN A CASE OF FEVER OF UNCLEAR AETIOLOGY 审中-公开用于建立感染发生源的方法在不明原因感染的病例中公开(公告)号：US20100041564A1
公开(公告)日：2010-02-18
申请号：US12305195
申请日：2007-06-06
申请人： Stefan Russwurm , Konrad Reinhart , Michael Bauer
发明人： Stefan Russwurm , Konrad Reinhart , Michael Bauer
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158
摘要： Use of gene expression profiles obtained in vitro from a patient's sample for establishing the local infection of a “fever of unknown origin”, wherein the gene expression profiles are specific for local inflammations of a “fever of unknown origin”, such as peritonitis, pneumonia, endocarditis or infections of the urea tract.
摘要翻译： 使用从患者样品体外获得的基因表达谱，以建立“未知来源的发热”的局部感染，其中基因表达谱对于“不明来源的发热”的局部炎症是特异性的，例如腹膜炎，肺炎 ，心内膜炎或尿道感染。
-
7.发明授权公开(公告)号：US08476200B2
公开(公告)日：2013-07-02
申请号：US11577102
申请日：2005-08-18
申请人： Stefan Russwurm , Konrad Reinhart
发明人： Stefan Russwurm , Konrad Reinhart
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention relates to the use of gene expression profiles obtained in vitro from patient samples for differentiating between the non-infectious and infectious causes of multiple organ failure. The invention also relates to a method for measuring gene expression profiles in vitro and the use of said gene expression profiles and/or of the probes used therein for screening active substances against the non-infectious and/or infectious causes of multiple organ failure.
摘要翻译： 本发明涉及从患者样品体外获得的基因表达谱的用途，用于区分多器官衰竭的非传染性和感染性原因。 本发明还涉及用于测量体外基因表达谱的方法以及所述基因表达谱和/或其中所用探针用于筛选针对多器官功能衰竭的非感染和/或感染原因的活性物质的方法。
-
8.发明申请METHOD FOR DIFFERENTIATING BETWEEN THE NON-INFECTIOUS AND INFECTIOUS CAUSES OF MULTIPLE ORGAN FAILURE 失效非感染性和多器官功能障碍的感染性病因分化方法公开(公告)号：US20090075831A1
公开(公告)日：2009-03-19
申请号：US11577102
申请日：2005-08-18
申请人： Stefan Russwurm , Konrad Reinhart
发明人： Stefan Russwurm , Konrad Reinhart
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention relates to the use of gene expression profiles obtained in vitro from patient samples for differentiating between the non-infectious and infectious causes of multiple organ failure. The invention also relates to a method for measuring gene expression profiles in vitro and the use of said gene expression profiles and/or of the probes used therein for screening active substances against the non-infectious and/or infectious causes of multiple organ failure.
摘要翻译： 本发明涉及从患者样品体外获得的基因表达谱的用途，用于区分多器官衰竭的非传染性和感染性原因。 本发明还涉及用于测量体外基因表达谱的方法以及所述基因表达谱和/或其中所用探针用于筛选针对多器官功能衰竭的非感染性和/或感染原因的活性物质的方法。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.023 秒)
