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    Use of a biochip for the diagnosis of sepsis or sepsis related syndrome
    3.
    发明申请
    Use of a biochip for the diagnosis of sepsis or sepsis related syndrome 审中-公开
    使用生物芯片诊断败血症或败血症相关综合征

    公开(公告)号：US20060134685A1

    公开(公告)日：2006-06-22

    申请号：US11349387

    申请日：2006-02-06

    申请人： Peter Zipfel ,  Hans-Peter Saluz ,  Stefan Russwurm ,  Konrad Reinhart

    发明人： Peter Zipfel ,  Hans-Peter Saluz ,  Stefan Russwurm ,  Konrad Reinhart

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： C12Q1/6837

    摘要： The application relates to the use of a nucleic acid and/or protein chip comprising probe nucleic acids and/or probe proteins, which are specific for cellular stress, inflammatory and immune reactions, associated with stress, inflammatory and immune reactions, induced during acute phase responses or any combination thereof and which are immobilised on a carrier for the diagnosis of sepsis or sepsis related syndrome.

    摘要翻译： 本申请涉及包含探针核酸和/或探针蛋白的核酸和/或蛋白质芯片在与急性期诱导的应激，炎症和免疫反应相关的细胞应激，炎性和免疫反应特异性的应用 反应或其任何组合，并且其固定在用于诊断败血症或败血症相关综合征的载体上。

    Novel Regulators of the Innate Immune System
    5.
    发明申请
    Novel Regulators of the Innate Immune System 审中-公开
    先天免疫系统的新型调节器

    公开(公告)号：US20110236455A1

    公开(公告)日：2011-09-29

    申请号：US13121029

    申请日：2009-09-28

    申请人： Peter Zipfel ,  Christina Skerka ,  Reinhard Wallich

    发明人： Peter Zipfel ,  Christina Skerka ,  Reinhard Wallich

    IPC分类号： A61K38/17 ,  C07K14/46 ,  A61M31/00 ,  C07K16/18 ,  C12N5/16 ,  G01N33/577 ,  A61P29/00 ,  A61L33/12

    CPC分类号： A61L27/54 ,  A61K38/00 ,  A61L27/22 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/41 ,  A61L2300/434 ,  C07K14/472 ,  C07K14/811 ,  C07K16/18 ,  G01N33/92 ,  G01N2800/347

    摘要： The present invention relates to the identification of novel regulators of the innate immune system, in particular the complement system. More particularly, the present invention relates to specific C5 convertase inhibitors. These novel inhibitors are particularly useful for treating inflammatory diseases involving the complement system. In a first aspect, the present invention focuses on the use of CFHR proteins and functional fragments or functional derivatives thereof for preventing inflammatory reactions. In a further aspect, the present invention focuses on the use of said CFHR proteins for inactivating complement activation during transplantation and dialysis and for coating devices which come into contact with blood or body fluids, in particular implants. The invention furthermore provides a pharmaceutical composition comprising functional CFHR protein in combination with functional factor H. In a further aspect, the present invention focuses on providing monoclonal antibodies which specifically detect CFHR proteins, and on the use thereof in methods of determining CFHR in body fluids. These methods are particularly suitable for diagnosing inflammatory diseases.

    摘要翻译： 本发明涉及先天免疫系统，特别是补体系统的新型调节剂的鉴定。 更具体地说，本发明涉及具体的C5转化酶抑制剂。 这些新型抑制剂特别适用于治疗涉及补体系统的炎性疾病。 在第一方面，本发明着重于CFHR蛋白及其功能片段或其功能衍生物用于预防炎症反应的用途。 在另一方面，本发明着重于所述CFHR蛋白在移植和透析期间灭活补体活化以及与血液或体液（特别是植入物）接触的涂覆装置的用途。 本发明还提供了包含与功能性因子H组合的功能性CFHR蛋白质的药物组合物。在另一方面，本发明着重于提供特异性检测CFHR蛋白质的单克隆抗体，以及在确定体液中CFHR的方法中的用途 。 这些方法特别适用于诊断炎性疾病。