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![5 OXO-5,8-DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AS CAMKII KINASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES](/abs-image/US/2012/11/01/US20120277220A1/abs.jpg.150x150.jpg)
1.发明申请5 OXO-5,8-DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AS CAMKII KINASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES 有权5 OXO-5,8-二氢吡啶并[2,3-d]吡啶衍生物作为用于治疗心血管疾病的CAMKII激酶抑制剂公开(公告)号：US20120277220A1
公开(公告)日：2012-11-01
申请号：US13544209
申请日：2012-07-09
IPC分类号： A61K31/519 , C07D239/47 , A61K31/5377 , A61K31/551 , A61K31/541 , A61K31/496 , A61P9/00 , A61P9/10 , A61P9/06 , A61P13/12 , A61P1/16 , A61P25/28 , A61P25/16 , A61P29/00 , A61P25/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to 5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives, to their preparation and to their therapeutic use.
摘要翻译： 本发明涉及5-氧代-5,8-二氢吡啶并[2,3-d]嘧啶衍生物及其制备方法及其治疗用途。
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2.发明申请DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS 有权7-烷基-1,3-萘二酮的衍生物，其制备方法及其在治疗中的应用公开(公告)号：US20100144757A1
公开(公告)日：2010-06-10
申请号：US12631122
申请日：2009-12-04
申请人： Antoine ALAM , Sandrine BISCARRAT , Isabelle BLANC , Francoise BONO , Olivier DUCLOS , Gary MCCORT
发明人： Antoine ALAM , Sandrine BISCARRAT , Isabelle BLANC , Francoise BONO , Olivier DUCLOS , Gary MCCORT
IPC分类号： A61K31/4375 , C07D471/04 , A61K31/497 , A61P35/00 , A61P25/00 , A61P29/00
CPC分类号： C07D213/73 , C07D213/82 , C07D471/04
摘要： The disclosure relates to 7-alkynyl-1,8-naphthyridones of formula (I): wherein R1, R2, R3, and R4 are as defined in the disclosure, to compositions containing them, to processes for preparing them, and to their use in therapeutics.
摘要翻译： 本公开涉及式（I）的7-炔基-1,8-萘啶酮：其中R1，R2，R3和R4如本公开所定义，含有它们的组合物，其制备方法及其用途 在治疗。
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3.发明申请公开(公告)号：US20100056553A1
公开(公告)日：2010-03-04
申请号：US12487503
申请日：2009-06-18
申请人： Oliver PLETTENBURG , Katrin LORENZ , Jochen GOERLITZER , Matthias Löhn , Sandrine BISCARRAT , Fréderic JEANNOT , Olivier DUCLOS
发明人： Oliver PLETTENBURG , Katrin LORENZ , Jochen GOERLITZER , Matthias Löhn , Sandrine BISCARRAT , Fréderic JEANNOT , Olivier DUCLOS
CPC分类号： C07D217/24
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉酮衍生物， 化合物。
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![6-(4-HYDROXY-PHENYL)-3-STYRYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS](/abs-image/US/2013/03/14/US20130065894A1/abs.jpg.150x150.jpg)
4.发明申请6-(4-HYDROXY-PHENYL)-3-STYRYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS 有权6-（4-羟基苯基）-3-苯乙烯基-1H-吡唑并[3,4-b]吡啶-4-羧酸酰胺衍生物作为激酶抑制剂公开(公告)号：US20130065894A1
公开(公告)日：2013-03-14
申请号：US13230365
申请日：2011-09-12
申请人： Matthias LOEHN , Maria MENDEZ-PEREZ , Stefania PFEIFFER-MAREK , Aimo KANNT , Guillaume BEGIS , Olivier DUCLOS , Federic JEANNOT
发明人： Matthias LOEHN , Maria MENDEZ-PEREZ , Stefania PFEIFFER-MAREK , Aimo KANNT , Guillaume BEGIS , Olivier DUCLOS , Federic JEANNOT
IPC分类号： A61K31/496 , C07D413/14 , A61K31/5377 , C07D471/04 , A61K31/4545 , A61K31/437 , A61P3/10 , A61P13/12 , A61P25/00 , A61P27/02 , A61P9/10 , A61P29/00 , A61P9/00 , A61P17/00 , A61P37/00 , A61P35/00 , C07D487/04
CPC分类号： C07D413/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to pyrazolo[3,4-b]pyridine compounds of the formula I, in which R1, R2, R3, R4 and R5 are defined as indicated below. The compounds of the formula I are kinase inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula I, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及式I的吡唑并[3,4-b]吡啶化合物，其中R 1，R 2，R 3，R 4和R 5如下所定义。 式I的化合物是激酶抑制剂，并且可用于治疗与糖尿病和糖尿病并发症相关的疾病，例如糖尿病性肾病，糖尿病性神经病和糖尿病性视网膜病变。 本发明还涉及式I化合物，特别是作为药物中的活性成分的用途，以及包含它们的药物组合物。
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5.发明申请DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS 有权7-烷基-1,3-萘二酮的衍生物，其制备方法及其在治疗中的应用公开(公告)号：US20100144782A1
公开(公告)日：2010-06-10
申请号：US12631130
申请日：2009-12-04
申请人： Antoine ALAM , Francoise BONO , Olivier DUCLOS , Gary MCCORT
发明人： Antoine ALAM , Francoise BONO , Olivier DUCLOS , Gary MCCORT
IPC分类号： A61K31/4375 , C07D471/04 , A61P35/00 , A61P17/00 , A61P9/10 , A61P27/02
CPC分类号： C07D471/04
摘要： The disclosure relates to compounds of formula (I): wherein R1, R2, R3, and R4 are as defined in the disclosure, to compositions containing them, to processes for preparing them, and to their use in therapeutics.
摘要翻译： 本公开涉及式（I）化合物：其中R 1，R 2，R 3和R 4如本公开所定义，含有它们的组合物，其制备方法及其在治疗中的应用。
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6.发明申请ARYLSULFONAMIDE PYRIDINE-PYRIDINONE DERIVATIVES, PREPARATION OF SAME, AND THERAPEUTIC USE THEREOF 审中-公开芳香酰胺吡啶 - 吡啶酮衍生物，其制备及其治疗用途公开(公告)号：US20130178472A1
公开(公告)日：2013-07-11
申请号：US13539706
申请日：2012-07-02
IPC分类号： C07D471/04 , A61K31/4375 , C07F5/02 , A61K45/06 , A61K31/444 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/4375 , A61K31/444 , A61K31/5377 , A61K45/06 , C07F5/025
摘要： The invention relates to pyridine-pyridinone derivatives general formula (I): in which R1, R2, R3, R4, n, n′, V, W, Y, Z, Ar are as defined in the description, and to their methods of preparation and their therapeutic applications.
摘要翻译： 本发明涉及通式（I）的吡啶 - 吡啶酮衍生物：其中R1，R2，R3，R4，n，n'，V，W，Y，Z，Ar如说明书中所定义， 制剂及其治疗应用。
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7.发明申请ANTINEOPLASTIC DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF 审中-公开抗生素衍生物，其制备方法及其治疗方法公开(公告)号：US20110251194A1
公开(公告)日：2011-10-13
申请号：US12986642
申请日：2011-01-07
申请人： Claude BERNHART , Gary MCCORT , Samir JEGHAM , Jean Marc HERBERT , Pierre CASELLAS , Monsif BOUABOULA , Olivier DUCLOS
发明人： Claude BERNHART , Gary MCCORT , Samir JEGHAM , Jean Marc HERBERT , Pierre CASELLAS , Monsif BOUABOULA , Olivier DUCLOS
IPC分类号： A61K31/496 , C07D401/02 , A61K31/5377 , A61K31/4709 , A61P35/00 , C07D471/04 , A61K31/444
CPC分类号： C07D471/04 , C07D401/12 , C07D401/14 , C07D407/14
摘要： The disclosure concerns heterobicyclic compounds of general formula (I) and acid addition salts, hydrates and solvates thereof, as well as enantiomers, diastereoisomers and mixtures thereof. Methods for preparing the compounds, pharmaceutical compositions, and methods of treatment also are disclosed.
摘要翻译： 本公开涉及通式（I）的杂双环化合物及其酸加成盐，水合物和溶剂合物，以及对映异构体，非对映异构体及其混合物。 还公开了制备化合物的方法，药物组合物和治疗方法。
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8.发明申请NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF 有权新型三亚甲基嘧啶衍生物，其制备方法及其治疗用途公开(公告)号：US20130261106A1
公开(公告)日：2013-10-03
申请号：US13855246
申请日：2013-04-02
申请人： Jean-Christophe CARRY , Fabienne CHATREAUX , Stephanie DEPRETS , Olivier DUCLOS , Vincent LEROY , Sergio MALLART , Dominique MELON-MANGUER , Maria MENDEZ-PEREZ , Fabrice VERGNE
发明人： Jean-Christophe CARRY , Fabienne CHATREAUX , Stephanie DEPRETS , Olivier DUCLOS , Vincent LEROY , Sergio MALLART , Dominique MELON-MANGUER , Maria MENDEZ-PEREZ , Fabrice VERGNE
IPC分类号： C07D495/04
CPC分类号： A61K31/553 , A61K31/519 , A61K31/55 , A61K31/551 , C07D495/04
摘要： The present invention relates to compounds of formula (I): wherein R6 is —CONH2 or a —C(Rα)(Rβ)(OH) group; R is a substituted phenyl or heteroaryl group; R7 is an optionally substituted aryl or heteroaryl group.Process for the preparation thereof and therapeutic use thereof.
摘要翻译： 本发明涉及式（I）化合物：其中R6是-CONH2或-C（Ralpha）（Rbeta）（OH）基团; R是取代的苯基或杂芳基; R 7是任选取代的芳基或杂芳基。 制备方法及其治疗用途。
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9.发明申请2-AMINO-3-(IMIDAZOL-2-YL)-PYRIDIN-4-ONE DERIVATIVES AND THEIR USE AS VEGF RECEPTOR KINASE INHIBITORS 有权2-氨基-3-（咪唑-2-基） - 吡啶-4-酮衍生物及其作为VEGF受体激酶抑制剂的用途公开(公告)号：US20140094488A1
公开(公告)日：2014-04-03
申请号：US14117750
申请日：2012-05-16
申请人： Alain BRAUN , Olivier DUCLOS , Gilbert LASSALLE , Franz LORGE , Valerie MARTIN , Olaf RITZELER , Aurelie STRUB
发明人： Alain BRAUN , Olivier DUCLOS , Gilbert LASSALLE , Franz LORGE , Valerie MARTIN , Olaf RITZELER , Aurelie STRUB
IPC分类号： C07D401/04 , A61K31/4709 , A61K45/06 , C07D471/04 , A61K31/4375
CPC分类号： A61K31/4709 , A61K31/4375 , A61K45/06 , C07D401/04 , C07D471/04
摘要： The invention relates to the compounds of general formula (I): Preparation process and therapeutic use.
摘要翻译： 本发明涉及通式（I）的化合物：制备方法和治疗用途。
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