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1.发明申请Novel ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof 有权RAR受体的新型配体拮抗剂及其药物/化妆品应用公开(公告)号：US20050234131A1
公开(公告)日：2005-10-20
申请号：US11116344
申请日：2005-04-28
IPC分类号： A61K31/19 , A61K31/195 , A61P17/00 , C07C63/36 , C07C63/64 , C07C63/66 , C07C65/11 , C07C65/19 , C07C65/28 , C07C65/34 , C07C65/38 , C07C69/76 , C07C229/18 , C07C229/38 , C07C229/52 , C07C233/54 , C07C235/38 , C07C235/42 , C07C235/78 , C07C259/10 , C07C271/28 , C07C323/62 , C07C391/02 , C07D213/30 , C07D213/79 , C07D213/80 , C07D333/16
CPC分类号： C07D213/79 , C07B2200/07 , C07C63/36 , C07C63/64 , C07C63/66 , C07C65/11 , C07C65/19 , C07C65/28 , C07C65/34 , C07C65/38 , C07C69/76 , C07C229/18 , C07C229/38 , C07C229/52 , C07C233/54 , C07C235/38 , C07C235/42 , C07C235/78 , C07C259/10 , C07C271/28 , C07C323/62 , C07C391/02 , C07C2602/10 , C07D213/30 , C07D213/80 , C07D333/16
摘要： Novel ligand antagonists of the RAR receptors have the following structural formula (1): in which A is a CH2, CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical selected from among those of formulae (a) to (f): and Ar is a radical selected from among those of formulae (g) to (i):
摘要翻译： RAR受体的新配体拮抗剂具有以下结构式（1）：其中A是CH 2，CHOH，C-O或C-N-OH基或硫或硒原子; B为选自式（a）〜（f）的基团：Ar为选自式（g）〜（i）的基团：
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2.发明授权Ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof 有权RAR受体的配体拮抗剂及其药物/化妆品应用公开(公告)号：US07348449B2
公开(公告)日：2008-03-25
申请号：US11116344
申请日：2005-04-28
IPC分类号： C07C69/76 , C07C59/76 , C07C233/00 , A01N47/10 , A01N37/10
CPC分类号： C07D213/79 , C07B2200/07 , C07C63/36 , C07C63/64 , C07C63/66 , C07C65/11 , C07C65/19 , C07C65/28 , C07C65/34 , C07C65/38 , C07C69/76 , C07C229/18 , C07C229/38 , C07C229/52 , C07C233/54 , C07C235/38 , C07C235/42 , C07C235/78 , C07C259/10 , C07C271/28 , C07C323/62 , C07C391/02 , C07C2602/10 , C07D213/30 , C07D213/80 , C07D333/16
摘要： Novel ligand antagonists of the RAR receptors have the following structural formula (I): in which A is a CH2, CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical selected from among those of formulae (a) to (f): and Ar is a radical selected from among those of formulae (g) to (i):
摘要翻译： RAR受体的新配体拮抗剂具有以下结构式（I）：其中A是CH 2，CHOH，C-O或C-N-OH基或硫或硒原子; B为选自式（a）〜（f）的基团：Ar为选自式（g）〜（i）的基团：
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3.发明申请Novel ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof 有权RAR受体的新型配体拮抗剂及其药物/化妆品应用公开(公告)号：US20080213347A1
公开(公告)日：2008-09-04
申请号：US11978623
申请日：2007-10-30
IPC分类号： A61K9/127 , C07C63/06 , A61K31/192 , A61P31/12 , A61P17/06 , A61P17/10 , C07D213/80 , A61K31/455
CPC分类号： C07D213/79 , C07B2200/07 , C07C63/36 , C07C63/64 , C07C63/66 , C07C65/11 , C07C65/19 , C07C65/28 , C07C65/34 , C07C65/38 , C07C69/76 , C07C229/18 , C07C229/38 , C07C229/52 , C07C233/54 , C07C235/38 , C07C235/42 , C07C235/78 , C07C259/10 , C07C271/28 , C07C323/62 , C07C391/02 , C07C2602/10 , C07D213/30 , C07D213/80 , C07D333/16
摘要： Novel ligand antagonists of the RAR receptors have the following structural formula (I): in which A is a CH2, CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical selected from among those of formulae (a) to (f): and Ar is a radical selected from among those of formulae (g) to (i):
摘要翻译： RAR受体的新配体拮抗剂具有以下结构式（I）：其中A是CH 2，CHOH，C-O或C-N-OH基或硫或硒原子; B为选自式（a）〜（f）的基团：Ar为选自式（g）〜（i）的基团：
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4.发明申请Novel modulators of the PPAR-type receptors and pharmaceutical/cosmetic applications thereof 失效PPAR型受体的新型调节剂及其药物/化妆品应用公开(公告)号：US20070054907A1
公开(公告)日：2007-03-08
申请号：US11450392
申请日：2006-06-12
申请人： Philippe Diaz , Catherine Raffin
发明人： Philippe Diaz , Catherine Raffin
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4196 , C07D403/02 , C07D413/02
CPC分类号： C07D409/06 , C07D249/12 , C07D403/06
摘要： Novel compounds that are modulators of PPAR-type receptors having the structural formula (I): are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and in the field of cardiovascular diseases, immune diseases and/or diseases linked to the metabolism of lipids), or, alternatively, into cosmetic compositions.
摘要翻译： 作为具有结构式（I）的PPAR-型受体的调节剂的新型化合物被配制成适用于人或兽医学（在皮肤病学和心血管疾病，免疫疾病和/或疾病相关的疾病领域）的药物组合物 对于脂质的代谢），或者替代地，进入化妆品组合物。
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5.发明授权Modulators of the PPAR-type receptors and pharmaceutical/cosmetic applications thereof 失效PPAR型受体的调节剂及其药物/化妆品应用公开(公告)号：US07829588B2
公开(公告)日：2010-11-09
申请号：US11450392
申请日：2006-06-12
申请人： Philippe Diaz , Catherine Raffin
发明人： Philippe Diaz , Catherine Raffin
IPC分类号： A61K31/41 , C07D249/00
CPC分类号： C07D409/06 , C07D249/12 , C07D403/06
摘要： Novel compounds that are modulators of PPAR-type receptors having the structural formula (I): are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and in the field of cardiovascular diseases, immune diseases and/or diseases linked to the metabolism of lipids), or, alternatively, into cosmetic compositions.
摘要翻译： 作为具有结构式（I）的PPAR-型受体的调节剂的新型化合物被配制成适用于人或兽医学（在皮肤病学和心血管疾病，免疫疾病和/或疾病相关的疾病领域）的药物组合物 对于脂质的代谢），或者替代地，进入化妆品组合物。
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6.发明授权Ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof 有权RAR受体的配体拮抗剂及其药物/化妆品应用公开(公告)号：US07592478B2
公开(公告)日：2009-09-22
申请号：US11978623
申请日：2007-10-30
CPC分类号： C07D213/79 , C07B2200/07 , C07C63/36 , C07C63/64 , C07C63/66 , C07C65/11 , C07C65/19 , C07C65/28 , C07C65/34 , C07C65/38 , C07C69/76 , C07C229/18 , C07C229/38 , C07C229/52 , C07C233/54 , C07C235/38 , C07C235/42 , C07C235/78 , C07C259/10 , C07C271/28 , C07C323/62 , C07C391/02 , C07C2602/10 , C07D213/30 , C07D213/80 , C07D333/16
摘要： Novel ligand antagonists of the RAR receptors have the following structural formula (I): in which A is a CH2, CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical selected from among those of formulae (a) to (f): and Ar is a radical selected from among those of formulae (g) to (i):
摘要翻译： RAR受体的新型配体拮抗剂具有以下结构式（I）：其中A是CH 2，CHOH，C-O或C-N-OH基或硫或硒原子; B为选自式（a）〜（f）的基团：Ar为选自式（g）〜（i）的基团：
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