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1.发明申请Novel ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof 有权RAR受体的新型配体拮抗剂及其药物/化妆品应用公开(公告)号：US20050234131A1
公开(公告)日：2005-10-20
申请号：US11116344
申请日：2005-04-28
IPC分类号： A61K31/19 , A61K31/195 , A61P17/00 , C07C63/36 , C07C63/64 , C07C63/66 , C07C65/11 , C07C65/19 , C07C65/28 , C07C65/34 , C07C65/38 , C07C69/76 , C07C229/18 , C07C229/38 , C07C229/52 , C07C233/54 , C07C235/38 , C07C235/42 , C07C235/78 , C07C259/10 , C07C271/28 , C07C323/62 , C07C391/02 , C07D213/30 , C07D213/79 , C07D213/80 , C07D333/16
CPC分类号： C07D213/79 , C07B2200/07 , C07C63/36 , C07C63/64 , C07C63/66 , C07C65/11 , C07C65/19 , C07C65/28 , C07C65/34 , C07C65/38 , C07C69/76 , C07C229/18 , C07C229/38 , C07C229/52 , C07C233/54 , C07C235/38 , C07C235/42 , C07C235/78 , C07C259/10 , C07C271/28 , C07C323/62 , C07C391/02 , C07C2602/10 , C07D213/30 , C07D213/80 , C07D333/16
摘要： Novel ligand antagonists of the RAR receptors have the following structural formula (1): in which A is a CH2, CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical selected from among those of formulae (a) to (f): and Ar is a radical selected from among those of formulae (g) to (i):
摘要翻译： RAR受体的新配体拮抗剂具有以下结构式（1）：其中A是CH 2，CHOH，C-O或C-N-OH基或硫或硒原子; B为选自式（a）〜（f）的基团：Ar为选自式（g）〜（i）的基团：
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2.发明授权Ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof 有权RAR受体的配体拮抗剂及其药物/化妆品应用公开(公告)号：US07348449B2
公开(公告)日：2008-03-25
申请号：US11116344
申请日：2005-04-28
IPC分类号： C07C69/76 , C07C59/76 , C07C233/00 , A01N47/10 , A01N37/10
CPC分类号： C07D213/79 , C07B2200/07 , C07C63/36 , C07C63/64 , C07C63/66 , C07C65/11 , C07C65/19 , C07C65/28 , C07C65/34 , C07C65/38 , C07C69/76 , C07C229/18 , C07C229/38 , C07C229/52 , C07C233/54 , C07C235/38 , C07C235/42 , C07C235/78 , C07C259/10 , C07C271/28 , C07C323/62 , C07C391/02 , C07C2602/10 , C07D213/30 , C07D213/80 , C07D333/16
摘要： Novel ligand antagonists of the RAR receptors have the following structural formula (I): in which A is a CH2, CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical selected from among those of formulae (a) to (f): and Ar is a radical selected from among those of formulae (g) to (i):
摘要翻译： RAR受体的新配体拮抗剂具有以下结构式（I）：其中A是CH 2，CHOH，C-O或C-N-OH基或硫或硒原子; B为选自式（a）〜（f）的基团：Ar为选自式（g）〜（i）的基团：
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3.发明授权Modulators of the PPAR-type receptors and pharmaceutical/cosmetic applications thereof 失效PPAR型受体的调节剂及其药物/化妆品应用公开(公告)号：US07829588B2
公开(公告)日：2010-11-09
申请号：US11450392
申请日：2006-06-12
申请人： Philippe Diaz , Catherine Raffin
发明人： Philippe Diaz , Catherine Raffin
IPC分类号： A61K31/41 , C07D249/00
CPC分类号： C07D409/06 , C07D249/12 , C07D403/06
摘要： Novel compounds that are modulators of PPAR-type receptors having the structural formula (I): are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and in the field of cardiovascular diseases, immune diseases and/or diseases linked to the metabolism of lipids), or, alternatively, into cosmetic compositions.
摘要翻译： 作为具有结构式（I）的PPAR-型受体的调节剂的新型化合物被配制成适用于人或兽医学（在皮肤病学和心血管疾病，免疫疾病和/或疾病相关的疾病领域）的药物组合物 对于脂质的代谢），或者替代地，进入化妆品组合物。
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4.发明授权Ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof 有权RAR受体的配体拮抗剂及其药物/化妆品应用公开(公告)号：US07592478B2
公开(公告)日：2009-09-22
申请号：US11978623
申请日：2007-10-30
CPC分类号： C07D213/79 , C07B2200/07 , C07C63/36 , C07C63/64 , C07C63/66 , C07C65/11 , C07C65/19 , C07C65/28 , C07C65/34 , C07C65/38 , C07C69/76 , C07C229/18 , C07C229/38 , C07C229/52 , C07C233/54 , C07C235/38 , C07C235/42 , C07C235/78 , C07C259/10 , C07C271/28 , C07C323/62 , C07C391/02 , C07C2602/10 , C07D213/30 , C07D213/80 , C07D333/16
摘要： Novel ligand antagonists of the RAR receptors have the following structural formula (I): in which A is a CH2, CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical selected from among those of formulae (a) to (f): and Ar is a radical selected from among those of formulae (g) to (i):
摘要翻译： RAR受体的新型配体拮抗剂具有以下结构式（I）：其中A是CH 2，CHOH，C-O或C-N-OH基或硫或硒原子; B为选自式（a）〜（f）的基团：Ar为选自式（g）〜（i）的基团：
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5.发明申请Novel ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof 有权RAR受体的新型配体拮抗剂及其药物/化妆品应用公开(公告)号：US20080213347A1
公开(公告)日：2008-09-04
申请号：US11978623
申请日：2007-10-30
IPC分类号： A61K9/127 , C07C63/06 , A61K31/192 , A61P31/12 , A61P17/06 , A61P17/10 , C07D213/80 , A61K31/455
CPC分类号： C07D213/79 , C07B2200/07 , C07C63/36 , C07C63/64 , C07C63/66 , C07C65/11 , C07C65/19 , C07C65/28 , C07C65/34 , C07C65/38 , C07C69/76 , C07C229/18 , C07C229/38 , C07C229/52 , C07C233/54 , C07C235/38 , C07C235/42 , C07C235/78 , C07C259/10 , C07C271/28 , C07C323/62 , C07C391/02 , C07C2602/10 , C07D213/30 , C07D213/80 , C07D333/16
摘要： Novel ligand antagonists of the RAR receptors have the following structural formula (I): in which A is a CH2, CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical selected from among those of formulae (a) to (f): and Ar is a radical selected from among those of formulae (g) to (i):
摘要翻译： RAR受体的新配体拮抗剂具有以下结构式（I）：其中A是CH 2，CHOH，C-O或C-N-OH基或硫或硒原子; B为选自式（a）〜（f）的基团：Ar为选自式（g）〜（i）的基团：
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6.发明申请Novel modulators of the PPAR-type receptors and pharmaceutical/cosmetic applications thereof 失效PPAR型受体的新型调节剂及其药物/化妆品应用公开(公告)号：US20070054907A1
公开(公告)日：2007-03-08
申请号：US11450392
申请日：2006-06-12
申请人： Philippe Diaz , Catherine Raffin
发明人： Philippe Diaz , Catherine Raffin
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4196 , C07D403/02 , C07D413/02
CPC分类号： C07D409/06 , C07D249/12 , C07D403/06
摘要： Novel compounds that are modulators of PPAR-type receptors having the structural formula (I): are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and in the field of cardiovascular diseases, immune diseases and/or diseases linked to the metabolism of lipids), or, alternatively, into cosmetic compositions.
摘要翻译： 作为具有结构式（I）的PPAR-型受体的调节剂的新型化合物被配制成适用于人或兽医学（在皮肤病学和心血管疾病，免疫疾病和/或疾病相关的疾病领域）的药物组合物 对于脂质的代谢），或者替代地，进入化妆品组合物。
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公开(公告)号：US08440832B2
公开(公告)日：2013-05-14
申请号：US12668840
申请日：2008-07-14
IPC分类号： C07D405/10 , C07D307/79 , A61K31/343
CPC分类号： C07D307/79 , A61K31/343 , A61K31/403 , A61K31/4525 , C07D209/08 , C07D209/14 , C07D209/34 , C07D307/80 , C07D307/81 , C07D407/12
摘要： Heterocyclic compounds which modulate cannabinoid receptors are presented. Pharmaceutical compositions containing these compounds, methods of using these compounds as modulators of cannabinoid receptors and processes for synthesizing these compounds are also described herein.
摘要翻译： 提出了调节大麻素受体的杂环化合物。 含有这些化合物的药物组合物，使用这些化合物作为大麻素受体的调节剂的方法以及合成这些化合物的方法也在本文中描述。
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公开(公告)号：US20100197755A1
公开(公告)日：2010-08-05
申请号：US12668867
申请日：2008-07-14
IPC分类号： A61K31/404 , C07D209/40 , A61P25/02 , A61P25/30
CPC分类号： C07D209/40
摘要： Hydrazone compounds which modulate cannabinoid receptors are presented. Pharmaceutical compositions containing these compounds, methods of using these compounds as modulators of cannabinoid receptors and processes for synthesizing these compounds are also described herein.
摘要翻译： 提出了调节大麻素受体的腙化合物。 含有这些化合物的药物组合物，使用这些化合物作为大麻素受体的调节剂的方法以及合成这些化合物的方法也在本文中描述。
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9.发明申请Novel modulators of the PPAR-type receptors and cosmetic/pharmaceutical compositions comprised thereof 审中-公开PPAR型受体的新型调节剂及其组合的美容/药物组合物公开(公告)号：US20060035969A1
公开(公告)日：2006-02-16
申请号：US11202059
申请日：2005-08-12
IPC分类号： A61K31/24 , C07C311/45
CPC分类号： C07C323/62 , C07C2601/14
摘要： Novel compounds which modulate PPAR-type receptors have the following general formula (I): and are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology and in the fields of cardiovascular diseases, immune diseases and/or diseases linked to lipid metabolism), or are formulated into cosmetic compositions.
摘要翻译： 调节PPAR-型受体的新型化合物具有以下通式（I）：并配制成适用于人或兽医学药物（在皮肤病学和心血管疾病，免疫疾病和/或与 脂质代谢），或配制成化妆品组合物。
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10.发明授权Heteroethylene compounds and pharmaceutical and cosmetic compositions containing same 有权异丙烯基化合物和含有它们的药物和化妆品组合物公开(公告)号：US06444709B1
公开(公告)日：2002-09-03
申请号：US09424816
申请日：2000-02-07
IPC分类号： A61K31095
CPC分类号： C07C323/54 , C07C391/02 , Y10S514/824 , Y10S514/825 , Y10S514/859 , Y10S514/861 , Y10S514/863 , Y10S514/864 , Y10S514/866 , Y10S514/88 , Y10S514/885 , Y10S514/886 , Y10S514/887 , Y10S514/902 , Y10S514/909 , Y10S514/912
摘要： The invention relates to novel heteroethynylenic compounds having the general formula (I): as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.
摘要翻译： 本发明涉及具有通式（I）的新型异硫醚化合物：以及这些化合物在预期用于人类或兽医药物（特别是皮肤病学，风湿性，呼吸道，心血管和眼科投诉）的药物组合物中的用途， 或者在化妆品组合物中。
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