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公开(公告)号：US5942413A
公开(公告)日：1999-08-24
申请号：US460998
申请日：1995-06-05
IPC分类号： A61K39/00 , A61K38/00 , A61K39/395 , A61P33/10 , C07K1/22 , C07K14/00 , C07K14/435 , C07K16/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12N15/11 , A61K39/002 , C12N15/30
CPC分类号： C07K14/4354 , A61K38/00 , Y10S530/822
摘要： Disclosed is a substantially purified antigen derived from a first species of parasitic nematodes, which antigen is capable of providing protection to a host from parasitism infestation by a second nematode species, which may be the same as or different from the first nematode species, following vaccination of the host with the antigen, characterized in that the antigen is proteinaceous, has a pI between 3.8 and 4.4, can be bound by lentil lectin and Helix promatia and has a molecular weight of approximately 45 kD as determined by SDS-PAGE.
摘要翻译： 公开了源自第一种寄生线虫的基本上纯化的抗原，该抗原能够在接种后能够向宿主提供对第一种线虫种类可能相同或不同的第二种线虫的寄生虫侵染的保护 的抗原，其特征在于抗原是蛋白质的，具有3.8至4.4之间的pI，可以被扁豆凝集素和螺旋状突起结合，并且通过SDS-PAGE测定具有约45kD的分子量。
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公开(公告)号：US5871738A
公开(公告)日：1999-02-16
申请号：US930685
申请日：1992-10-06
IPC分类号： A61K39/00 , A61K39/395 , A61P33/00 , A61P33/10 , C07K14/00 , C07K14/435 , C07K16/00 , C07K16/18 , C07K19/00 , C12N15/09 , C12N15/12 , C12P21/02 , C07K1/00
CPC分类号： C07K16/18 , C07K14/4354 , A61K39/00 , C12N2799/026
摘要： Disclosed is a substantially purified antigen derived from a first parasitic nematode species which, when administered to a host animal, is capable of protecting the host animal from infestation by a second parasitic nematode species, wherein the first and second parasitic nematode species may be the same or different, and the antigen has an apparent molecular weight of 40 kD as determined by SDS-PAGE under reducing conditions.
摘要翻译： PCT No.PCT / AU92 / 00041 Sec。 371日期：1992年10月6日 102（e）日期1992年10月6日PCT提交1992年2月6日PCT公布。 公开号WO92 / 13890 日期1992年8月20日公开是源自第一寄生线虫物种的基本纯化的抗原，当其施用于宿主动物时，能够通过第二寄生线虫种保护宿主动物免于侵染，其中第一和第二寄生线虫 物种可以相同或不同，并且抗原在还原条件下通过SDS-PAGE测定具有40kD的表观分子量。
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公开(公告)号：US5734035A
公开(公告)日：1998-03-31
申请号：US461005
申请日：1995-06-05
IPC分类号： A61K39/00 , A61K39/395 , A61P33/00 , A61P33/10 , C07K14/00 , C07K14/435 , C07K16/00 , C07K16/18 , C07K19/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12N15/11 , C12N15/00
CPC分类号： C07K16/18 , C07K14/4354 , A61K39/00 , C12N2799/026
摘要： Disclosed is a substantially purified antigen derived from a first parasitic nematode species which, when administered to a host animal, is capable of protecting the host animal from infestation by a second parasitic mematode species, wherein the first and second parasitic nematode species may be the same or different, and the antigen has an apparent molecular weight of 40 kD as determined by SDS-PAGE under reducing conditions.
摘要翻译： 公开了一种基本上纯化的抗原，其来源于第一寄生线虫物种，其在施用于宿主动物时能够通过第二寄生虫记忆物种保护宿主动物免于侵扰，其中第一和第二寄生线虫物种可以相同 或不同，并且抗原在还原条件下通过SDS-PAGE测定具有40kD的表观分子量。
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公开(公告)号：US06344189B1
公开(公告)日：2002-02-05
申请号：US09190451
申请日：1998-11-13
IPC分类号： A61K3174
CPC分类号： A61K38/06 , A61K38/57 , Y10S514/944
摘要： The healing of chronic wounds, such as leg ulcers, is accelerated via topical administration of a serine protease inhibitor, such as PAI-2. Wound healing also is promoted using combinations of protease inhibitors, such as PAI-2 with other serine protease inhibitors and/or with protease inhibitors such inhibitors of metalloproteinases, acid proteases, and thiol proteases, respectively.
摘要翻译： 通过局部施用丝氨酸蛋白酶抑制剂如PAI-2，加速慢性伤口（例如腿部溃疡）的愈合。 使用蛋白酶抑制剂如PAI-2与其他丝氨酸蛋白酶抑制剂和/或蛋白酶抑制剂分别与金属蛋白酶，酸性蛋白酶和硫醇蛋白酶的抑制剂组合来促进伤口愈合。
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公开(公告)号：US06288025B1
公开(公告)日：2001-09-11
申请号：US09368164
申请日：1999-08-05
IPC分类号： A61K3800
CPC分类号： A61K38/57
摘要： Psoriasis may be treated by topical administration of a urokinase inhibitor, such as PAI-2, or a combination of protease inhibitors, such as PAI-2 with other serine protease inhibitors and/or with protease inhibitors such as inhibitors of metalloproteinases, acid proteases, and thiol proteases.
摘要翻译： 牛皮癣可以通过局部施用尿素激酶抑制剂如PAI-2或蛋白酶抑制剂如PAI-2与其它丝氨酸蛋白酶抑制剂和/或与蛋白酶抑制剂如金属蛋白酶抑制剂，酸性蛋白酶， 和硫醇蛋白酶。
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