-
公开(公告)号:US20050032797A1
公开(公告)日:2005-02-10
申请号:US10940898
申请日:2004-09-14
申请人: Pier Cirillo , Abdelhakim Hammach , Victor Kamhi , Neil Moss , Paul Riska , Christopher Pargellis
发明人: Pier Cirillo , Abdelhakim Hammach , Victor Kamhi , Neil Moss , Paul Riska , Christopher Pargellis
IPC分类号: C07D239/34 , C07D239/46 , C07D239/52 , C07D401/12 , C07D405/12 , C07D521/00 , A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/506 , C07D413/04 , C07D43/04
CPC分类号: C07D249/08 , C07D231/12 , C07D233/56 , C07D239/34 , C07D239/47 , C07D239/52 , C07D401/12 , C07D405/12
摘要: Disclosed are compounds of formula(I): wherein R1, R2, W and X of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译: 公开了式(I)的化合物:其中式(I)的R 1,R 2,W和X在本文中定义。 该化合物抑制涉及炎症过程的细胞因子的产生,因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
-
2.
公开(公告)号:US08765399B2
公开(公告)日:2014-07-01
申请号:US13068682
申请日:2011-05-17
申请人: Paul Riska
发明人: Paul Riska
摘要: Disclosed are culture media, protocols and kits for diagnosis of toxigenic Clostridium difficile, where the culture medium comprises Cooked Meat Medium with glucose; yeast extract; taurocholate; cycloserine; and cefoxitin.
摘要翻译: 公开了用于诊断致病艰难梭菌的培养基,方案和试剂盒,其中培养基包括具有葡萄糖的熟肉培养基; 酵母抽提物; 牛磺胆酸盐 环丝氨酸 和头孢西丁。
-
3.
公开(公告)号:US20110287474A1
公开(公告)日:2011-11-24
申请号:US13068682
申请日:2011-05-17
申请人: Paul Riska
发明人: Paul Riska
摘要: Disclosed are culture media, protocols and kits for diagnosis of toxigenic Clostridium difficile, where the culture medium comprises Cooked Meat Medium with glucose; yeast extract; taurocholate; cycloserine; and cefoxitin.
摘要翻译: 公开了用于诊断致病艰难梭菌的培养基,方案和试剂盒,其中培养基包括具有葡萄糖的熟肉培养基; 酵母抽提物; 牛磺胆酸盐 环丝氨酸 和头孢西丁。
-
公开(公告)号:US5656424A
公开(公告)日:1997-08-12
申请号:US388916
申请日:1995-02-15
申请人: Stewart Jurgensen , Michael C. Little , Paul T. Hamilton , Paul Riska , John Chan , Barry R. Bloom
发明人: Stewart Jurgensen , Michael C. Little , Paul T. Hamilton , Paul Riska , John Chan , Barry R. Bloom
CPC分类号: C12Q1/66 , C12Q1/6897
摘要: Methods for using reporter mycobacteriophage (RM) and p-nitro-.alpha.-acetylamino-.beta.-hydroxy-propiophenone (NAP) to identify TB complex mycobacteria and distinguish these species from MOTT. RM-infected MOTT show little or no reduction in signal when treated with NAP. In contrast, TB complex mycobacteria infected with RM are distinguishable from RM-infected MOTT by a reduction in signal with NAP treatment.
摘要翻译: 使用报道分枝杆菌噬菌体(RM)和对硝基-α-乙酰氨基-β-羟基 - 苯丙酮(NAP)的方法来鉴定TB复合分枝杆菌并将这些物种与MOTT区分开来。 在用NAP治疗的情况下,RM感染的MOTT显示很少或没有减少信号。 相比之下,感染RM的TB复合分枝杆菌通过NAP治疗的信号减少与RM感染的MOTT区分开。
-
-
-