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    Medicinal and/or nutritional microcapsules for oral administration
    1.
    发明授权
    Medicinal and/or nutritional microcapsules for oral administration 失效
    用于口服给药的药用和/或营养微胶囊

    公开(公告)号：US6022562A

    公开(公告)日：2000-02-08

    申请号：US544208

    申请日：1995-10-17

    申请人： Pierre Autant ,  Jean-Philippe Selles ,  Gerard Soula

    发明人： Pierre Autant ,  Jean-Philippe Selles ,  Gerard Soula

    IPC分类号： A61K9/50 ,  A61K47/30 ,  A61K9/14

    CPC分类号： A61K9/5015 ,  A61K9/5026 ,  A61K9/5047

    摘要： The present invention relates to microcapsules for the oral administration of medicinal and/or nutritional active principles (AP), which are smaller than or equal to 1000 .mu.m in size. These microcapsules consist of particles which are coated with a coating material consisting of a mixture of a film-forming polymer derivative, a hydrophobic plasticizer, a functional agent and a nitrogen-containing polymer. These microcapsules are also characterized by their ability to remain in the small intestine for a long time (at least 5 hours) and to allow, during the residence, release and absorption of the AP. The invention also relates to a process for the production of the said microcapsules.

    摘要翻译： 本发明涉及用于口服施用小于或等于1000μm的药用和/或营养活性成分（AP）的微胶囊。 这些微胶囊由涂覆有由成膜聚合物衍生物，疏水增塑剂，官能剂和含氮聚合物的混合物组成的涂层材料的颗粒组成。 这些微胶囊的特征还在于它们能够长时间（至少5小时）保留在小肠中，并允许在AP的释放和吸收期间。 本发明还涉及生产所述微胶囊的方法。

    Compressed tablets comprising microcapsules with modified release
    2.
    发明申请
    Compressed tablets comprising microcapsules with modified release 有权
    包含经释放的微胶囊的压片

    公开(公告)号：US20050266078A1

    公开(公告)日：2005-12-01

    申请号：US10507886

    申请日：2003-03-14

    申请人： Rafael Jorda ,  Pierre Autant

    发明人： Rafael Jorda ,  Pierre Autant

    IPC分类号： A61K9/52 ,  A61K9/20 ,  A61K9/26 ,  A61K9/50 ,  A61K9/56 ,  A61K31/155 ,  A61K31/522 ,  A61K47/04 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/38 ,  A61K47/44 ,  A61K9/24

    CPC分类号： A61K9/2081 ,  A61K9/5073

    摘要： A multi(micro)particulate tablet is provided comprising microparticles which comprise a mechanically non-deformable core of active principle (AP). The tablet is formed from reservoir microcapsules with prolonged release of the AP, which are each made up of a non-deformable core comprising AP and covered with at least one film coating controlling release of the AP in vivo. The microcapsules have a particle size of between 50 and 1000 microns and are coated with at least one outer overcoating envelope comprising at least one deformable organic constituent having a melting point of between 40° C. and 120° C. The envelope allows the prolonged release of the AP in vivo without modification of the release profile when the microcapsules are compressed to form a tablet, even for microparticles not specifically formulated for compression.

    摘要翻译： 提供了包含微粒的多（微）颗粒片剂，其包含有机原理（AP）的机械不可变形核心。 片剂由具有延长AP释放的储存器微胶囊形成，其各自由包含AP的不可变形的芯构成并且覆盖有控制AP释放的至少一个膜涂层。 微胶囊具有50至1000微米的粒度，并且涂覆有至少一个外涂层外壳，其包含至少一种熔点在40℃和120℃之间的可变形有机成分。所述外壳允许延长释放 的AP，而在微胶囊被压缩形成片剂时即使对于未特别配制用于压缩的微粒也不改变释放曲线。

    Compressed tablets comprising microcapsules with modified release
    4.
    发明授权
    Compressed tablets comprising microcapsules with modified release 有权
    包含经释放的微胶囊的压片

    公开(公告)号：US08507003B2

    公开(公告)日：2013-08-13

    申请号：US10507886

    申请日：2003-03-14

    申请人： Rafaël Jorda ,  Pierre Autant

    发明人： Rafaël Jorda ,  Pierre Autant

    IPC分类号： A61K9/14 ,  A61K9/22 ,  A61K9/16

    CPC分类号： A61K9/2081 ,  A61K9/5073

    摘要： A multi(micro)particulate tablet is provided comprising microparticles which comprise a mechanically non-deformable core of active principle (AP). The tablet is formed from reservoir microcapsules with prolonged release of the AP, which are each made up of a non-deformable core comprising AP and covered with at least one film coating controlling release of the AP in vivo. The microcapsules have a particle size of between 50 and 1000 microns and are coated with at least one outer overcoating envelope comprising at least one deformable organic constituent having a melting point of between 40° C. and 120° C. The envelope allows the prolonged release of the AP in vivo without modification of the release profile when the microcapsules are compressed to form a tablet, even for microparticles not specifically formulated for compression.

    摘要翻译： 提供了包含微粒的多（微）颗粒片剂，其包含有机原理（AP）的机械不可变形核心。 片剂由具有延长AP释放的储存器微胶囊形成，其各自由包含AP的不可变形的芯构成并且覆盖有控制AP释放的至少一个膜涂层。 微胶囊具有50至1000微米的粒度，并且涂覆有至少一个外涂层外壳，其包含至少一种熔点在40℃和120℃之间的可变形有机成分。所述外壳允许延长释放 的AP，而在微胶囊被压缩形成片剂时即使对于未特别配制用于压缩的微粒也不改变释放曲线。

    Compositions for coating feedstuff additives for ruminants and feedstuff additives thus coated
    6.
    发明授权
    Compositions for coating feedstuff additives for ruminants and feedstuff additives thus coated 失效
    用于涂覆反刍动物和饲料添加剂的饲料添加剂的组合物

    公开(公告)号：US4877621A

    公开(公告)日：1989-10-31

    申请号：US92139

    申请日：1987-09-02

    申请人： Pierre Ardaillon ,  Pierre Autant ,  Paul Bourrain ,  Andre Cartillier

    发明人： Pierre Ardaillon ,  Pierre Autant ,  Paul Bourrain ,  Andre Cartillier

    IPC分类号： A23K1/16 ,  A23K1/00 ,  A23K1/18 ,  A61K9/42 ,  A61K9/50

    CPC分类号： A61K9/5026 ,  A23K40/35 ,  A23K50/10 ,  A61K9/5015

    摘要： A composition for coating a biologically active substance, which is stable in a medium with a pH greater than or equal to 5 and which enables the active substance to be released in a medium with a pH less than or equal to 3.5, consisting of a basic amino copolymer (preferably vinyl-pyridine/styrene copolymer) and a hydrophobic substance with a melting point greater than 60.degree. C. (preferably stearic acid), the hydrophobic substance content being between 50 and 90% of the total mass of the coating, and granules comprising a nucleous containing the biologically active substance, coated with this composition.

    摘要翻译： 一种用于涂覆生物活性物质的组合物，其在pH大于或等于5的介质中是稳定的，并且其能够使活性物质在pH小于或等于3.5的介质中释放，所述介质由碱性 氨基共聚物（优选乙烯基 - 吡啶/苯乙烯共聚物）和熔点大于60℃的疏水物质（优选硬脂酸），疏水物质含量在涂层总质量的50-90％之间，和 包含含有该组合物的生物活性物质的核的颗粒。