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1.发明授权Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins 有权针对胶质纤维酸性蛋白的骆驼重链抗体的可变结构域公开(公告)号：US08460888B2
公开(公告)日：2013-06-11
申请号：US13002910
申请日：2009-07-07
IPC分类号： G01N33/567 , C07K16/18 , C07K16/28 , A61K39/395
CPC分类号： A61K51/1018 , A61K2039/505 , A61K2039/54 , A61K2039/543 , A61K2039/545 , C07K16/18 , C07K16/3053 , C07K2317/22 , C07K2317/569 , C07K2317/92 , C12N5/0622
摘要： The present invention relates to the use of variable domains of camelid heavy-chain antibodies (VHH domains) directed against an intracellular target and having an isoelectric point of at least 8.5, for targeting said intracellular target or for the preparation of a peptide vector. Particularly, it concerns VHH domains directed against a glial fibrillary acidic protein and uses thereof for preparing therapeutic or diagnostic agents.
摘要翻译： 本发明涉及针对细胞内靶标并具有至少8.5的等电点的骆驼重链抗体（VHH结构域）的可变结构域的用途，用于靶向所述细胞内靶标或用于制备肽载体。 特别地，其涉及针对胶质纤维酸性蛋白质的VHH结构域及其用于制备治疗剂或诊断剂的用途。
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2.发明申请VARIABLE DOMAINS OF CAMELID HEAVY-CHAIN ANTIBODIES DIRECTED AGAINST GLIAL FIBRILLARY ACIDIC PROTEINS 有权针对玻璃纤维酸性蛋白质的针对重要链条抗体的可变域公开(公告)号：US20110250211A1
公开(公告)日：2011-10-13
申请号：US13002910
申请日：2009-07-07
IPC分类号： A61K39/395 , C07H21/00 , C12N15/63 , C12N1/00 , A61P25/00 , C12N5/071 , C12N9/96 , C12N7/00 , A61K31/7088 , A61P35/00 , C07K16/18 , G01N33/566
CPC分类号： A61K51/1018 , A61K2039/505 , A61K2039/54 , A61K2039/543 , A61K2039/545 , C07K16/18 , C07K16/3053 , C07K2317/22 , C07K2317/569 , C07K2317/92 , C12N5/0622
摘要： The present invention relates to the use of variable domains of camelid heavy-chain antibodies (VHH domains) directed against an intracellular target and having an isoelectric point of at least 8.5, for targeting said intracellular target or for the preparation of a peptide vector. Particularly, it concerns VHH domains directed against a glial fibrillary acidic protein and uses thereof for preparing therapeutic or diagnostic agents.
摘要翻译： 本发明涉及针对细胞内靶标并具有至少8.5的等电点的骆驼重链抗体（VHH结构域）的可变结构域的用途，用于靶向所述细胞内靶标或用于制备肽载体。 特别地，其涉及针对胶质纤维酸性蛋白质的VHH结构域及其用于制备治疗剂或诊断剂的用途。
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3.发明申请USE OF A CAMELID SINGLE-DOMAIN ANTIBODY FOR DETECTING AN OLIGOMERIC FORM OF AN AMYLOID BETA PEPTIDE AND ITS APPLICATIONS 审中-公开用于检测淀粉样蛋白肽的低聚体形式及其应用的CAMELID单抗体的使用公开(公告)号：US20100266576A1
公开(公告)日：2010-10-21
申请号：US12667172
申请日：2008-06-26
申请人： Francois Rougeon , Pierre Lafaye
发明人： Francois Rougeon , Pierre Lafaye
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/566 , C07K16/00
CPC分类号： C07K14/4711 , A61K2039/505 , C07K16/18 , C07K2317/22 , C07K2317/92 , G01N33/6896 , G01N2800/2821 , G01N2800/387
摘要： Use of camelid single-domain antibodies for detecting an oligomeric form of the amyloid β peptide 42 and their therapeutic and diagnostic applications.
摘要翻译： 使用骆驼单结构域抗体检测淀粉样蛋白和寡聚体的寡聚形式; 肽42及其治疗和诊断应用。
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4.发明授权VHH antibodies used as peptide vectors for delivering a substance of interest 有权用作递送感兴趣物质的肽载体的VHH抗体公开(公告)号：US09387260B2
公开(公告)日：2016-07-12
申请号：US12501094
申请日：2009-07-10
CPC分类号： C07K16/18 , A61K47/6803 , A61K47/6843 , A61K51/1018 , C07K2317/22 , C07K2317/569 , C07K2317/622 , C07K2317/92
摘要： Use of a variable fragment (VHH antibody) of a camelid single-chain antibody for the preparation of a peptide vector for delivering a substance of interest across the blood-brain barrier or into a cell.
摘要翻译： 使用骆驼单链抗体的可变片段（VHH抗体）用于制备用于在血脑屏障或细胞中递送目的物质的肽载体。
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