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公开(公告)号：US20110190259A1
公开(公告)日：2011-08-04
申请号：US13048636
申请日：2011-03-15
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号： A61K31/506 , C07D401/14 , C12N9/99 , C07D239/24 , C07D413/14 , A61K31/5377 , C07D403/02 , A61P25/00 , A61P37/06
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要翻译： 本发明提供新颖的嘧啶和吡啶衍生物及其药物组合物，以及使用这些化合物的方法。 例如，本发明的嘧啶和吡啶衍生物可用于治疗，改善或预防响应于间变性淋巴瘤激酶（ALK）活性，粘着斑激酶（FAK），ζ-链相关蛋白激酶70 （ZAP-70），胰岛素样生长因子（IGF-1R）或其组合。
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公开(公告)号：US20110257154A1
公开(公告)日：2011-10-20
申请号：US13172357
申请日：2011-06-29
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号： A61K31/397 , A61K31/506 , C07D239/48 , A61K31/505 , C07D413/14 , A61K31/5377 , C07D413/12 , C07D403/12 , A61K31/496 , C07D487/04 , A61K31/519 , A61K31/52 , A61P31/00 , A61P35/00 , C12N5/09 , C07D401/14
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
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公开(公告)号：US20150105390A1
公开(公告)日：2015-04-16
申请号：US14574063
申请日：2014-12-17
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje, III , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje, III , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号： A61K31/506 , A61K45/06 , A61K31/5377 , C07D239/48 , C07D401/14 , C07D401/12
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要翻译： 本发明提供新颖的嘧啶和吡啶衍生物及其药物组合物，以及使用这些化合物的方法。 例如，本发明的嘧啶和吡啶衍生物可用于治疗，改善或预防响应于间变性淋巴瘤激酶（ALK）活性，粘着斑激酶（FAK），ζ-链相关蛋白激酶70 （ZAP-70），胰岛素样生长因子（IGF-1R）或其组合。
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公开(公告)号：US08957081B2
公开(公告)日：2015-02-17
申请号：US13610422
申请日：2012-09-11
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje, III , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje, III , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号： A61K31/519 , A61K31/52 , A61K31/517 , C07D239/02 , C07D239/42 , C07D403/12 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要翻译： 本发明提供新颖的嘧啶和吡啶衍生物及其药物组合物，以及使用这些化合物的方法。 例如，本发明的嘧啶和吡啶衍生物可用于治疗，改善或预防响应于间变性淋巴瘤激酶（ALK）活性，粘着斑激酶（FAK），ζ-链相关蛋白激酶70 （ZAP-70），胰岛素样生长因子（IGF-1R）或其组合。
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公开(公告)号：US08399450B2
公开(公告)日：2013-03-19
申请号：US13172357
申请日：2011-06-29
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号： A61K31/4164 , A61K31/535 , A61K31/497 , A61K31/505 , C07D413/12 , C07D403/12 , C07D239/02
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
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公开(公告)号：US08372858B2
公开(公告)日：2013-02-12
申请号：US13048636
申请日：2011-03-15
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号： A61K31/505 , A61K31/535 , A61K31/03 , C07D239/42 , C07D403/12 , C07D239/02
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
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公开(公告)号：US20080176881A1
公开(公告)日：2008-07-24
申请号：US11943436
申请日：2007-11-20
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号： A61K31/505 , C07D239/48 , C12N9/99 , C07D213/38 , A61P35/00
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要翻译： 本发明提供新颖的嘧啶和吡啶衍生物及其药物组合物，以及使用这些化合物的方法。 例如，本发明的嘧啶和吡啶衍生物可用于治疗，改善或预防响应于间变性淋巴瘤激酶（ALK）活性，粘着斑激酶（FAK），ζ-链相关蛋白激酶70 （ZAP-70），胰岛素样生长因子（IGF-1R）或其组合。
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公开(公告)号：US20130005748A1
公开(公告)日：2013-01-03
申请号：US13610422
申请日：2012-09-11
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号： A61K31/519 , A61P31/00 , A61P35/00 , A61P37/06 , A61K31/52 , A61K31/517
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
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公开(公告)号：US08592432B2
公开(公告)日：2013-11-26
申请号：US12936199
申请日：2009-04-03
申请人： Bei Chen , Tao Jiang , Thomas H. Marsilje , Pierre-Yves Michellys , Truc Ngoc Nguyen , Wei Pei , Baogen Wu , Zhaobo Gao , Yonghui Ge , Chen Huang , Yuncheng Li , Xuefeng Zhu
发明人： Bei Chen , Tao Jiang , Thomas H. Marsilje , Pierre-Yves Michellys , Truc Ngoc Nguyen , Wei Pei , Baogen Wu , Zhaobo Gao , Yonghui Ge , Chen Huang , Yuncheng Li , Xuefeng Zhu
IPC分类号： A61K31/506 , A61K31/5377 , C07D239/42 , C07D239/30 , C07D295/108 , C07D487/04 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D487/04
摘要： The invention provides novel pyrimidine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, c-ros oncogene (ROS), insulin-like growth factor (IGF-1R), and/or insulin receptor (InsR) or a combination thereof.
摘要翻译： 本发明提供新颖的嘧啶衍生物及其药物组合物，以及使用这些化合物的方法。 例如，本发明的嘧啶衍生物可用于治疗，改善或预防对间变性淋巴瘤激酶（ALK）活性，c-ros致癌基因（ROS），胰岛素样生长因子（IGF-1R ）和/或胰岛素受体（InsR）或其组合。
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公开(公告)号：US20110135668A1
公开(公告)日：2011-06-09
申请号：US12936199
申请日：2009-04-03
申请人： Bei Chen , Tao Jiang , Thomas H. Marsilje , Pierre-Yves Michellys , Truc Ngoc Nguyen , Pei Wei , Baogen Wu , Zhaobo Gao , Yonghui Ge , Chen Huang , Yuncheng Li
发明人： Bei Chen , Tao Jiang , Thomas H. Marsilje , Pierre-Yves Michellys , Truc Ngoc Nguyen , Pei Wei , Baogen Wu , Zhaobo Gao , Yonghui Ge , Chen Huang , Yuncheng Li
IPC分类号： A61K39/00 , C07D401/12 , C07D487/04 , C07D413/14 , C07D401/14 , A61K31/506 , A61K31/519 , A61K31/5377 , A61P35/00
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D487/04
摘要： The invention provides novel pyrimidine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, c-ros oncogene (ROS), insulin-like growth factor (IGF-1R), and/or insulin receptor (InsR) or a combination thereof.
摘要翻译： 本发明提供新颖的嘧啶衍生物及其药物组合物，以及使用这些化合物的方法。 例如，本发明的嘧啶衍生物可用于治疗，改善或预防对间变性淋巴瘤激酶（ALK）活性，c-ros致癌基因（ROS），胰岛素样生长因子（IGF-1R ）和/或胰岛素受体（InsR）或其组合。
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