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    Systems and methods for electrochemical point-of-care detection of hemoglobin
    1.
    发明授权
    Systems and methods for electrochemical point-of-care detection of hemoglobin 有权

    公开(公告)号：US11693016B2

    公开(公告)日：2023-07-04

    申请号：US16698872

    申请日：2019-11-27

    申请人： POLYMER TECHNOLOGY SYSTEMS, INC.

    发明人： Donnie Smith ,  Brittney L. Werner ,  Gary L. Hughes ,  Jie Chen

    IPC分类号： G01N33/72 ,  G01N27/327 ,  C12N9/50

    CPC分类号： G01N33/721 ,  C12N9/50 ,  G01N27/3272 ,  G01N33/723

    摘要： A method for determining analytes includes lysing the red blood cells of a whole blood sample, oxidizing the free hemoglobin in the lysed sample, and cleaving FVH from the hemoglobin A1C to form an electrochemical test solution. In one aspect, a first portion of the electrochemical test solution is reacted with fructosyl peptide oxidase and a reduced ruthenium mediator to form a first reaction product. A first electrical property of the first reaction product is measured, the measurement being indicative of hemoglobin A1C in the blood sample. In another aspect, a second portion of the electrochemical test solution is reacted with ferrocyanide to form a second reaction product. A second electrical property of the second reaction product is measured, the measurement being indicative of total hemoglobin in the blood sample. Hemoglobin A1C, total hemoglobin, and % HbA1C are determined based on the first and second electrical properties.

    SYSTEMS AND METHODS FOR POINT-OF-CARE HDL AND LDL PARTICLE ASSAY
    2.
    发明申请
    SYSTEMS AND METHODS FOR POINT-OF-CARE HDL AND LDL PARTICLE ASSAY 审中-公开

    公开(公告)号：US20170176472A1

    公开(公告)日：2017-06-22

    申请号：US15382367

    申请日：2016-12-16

    申请人： Polymer Technology Systems, Inc.

    发明人： Aniruddha Patwardhan ,  Gary L. Hughes

    IPC分类号： G01N33/92

    CPC分类号： G01N33/92 ,  G01N33/558 ,  G01N2333/775 ,  G01N2800/32 ,  G01N2800/50

    摘要： A system for testing for LDL-Particles (LDL-P) and HDL-Particles (HDL-P) includes a first lateral flow test strip and a second lateral flow test strip; and a dosing area, the dosing area interconnected with the first and second lateral flow test strips. The system further includes a collector for collecting a sample; and a first mixer for receiving the sample from the collector, the mixer including buffers for mixing with the sample, the first mixer for dosing the sample pad, wherein the first lateral flow test strip provides for the detection of HDL-P and the second lateral flow test strip provides for the detection of LDL-P.

    SYSTEMS AND METHODS FOR ELECTROCHEMICAL KETONE DETECTION AND MEASUREMENT
    3.
    发明申请
    SYSTEMS AND METHODS FOR ELECTROCHEMICAL KETONE DETECTION AND MEASUREMENT 审中-公开
    电化学检测和测量的系统和方法

    公开(公告)号：US20160327562A1

    公开(公告)日：2016-11-10

    申请号：US15134156

    申请日：2016-04-20

    申请人： Polymer Technology Systems, Inc.

    发明人： Gary L. Hughes ,  Aniruddha Patwardhan

    IPC分类号： G01N33/64 ,  G01N27/327 ,  G01N33/66 ,  G01N27/416

    摘要： A system for the electrochemical detection of ketone levels includes a test strip including an electrode and a counter electrode, the electrode and counter electrode located in a sample reception area. The system further includes a coating on one of the electrode and counter electrode, the coating including a mediator for ketones. Optionally, the mediator is ferricyanide.

    摘要翻译： 用于酮水平的电化学检测的系统包括测试条，其包括电极和对电极，电极和对电极位于样品接收区域中。 该系统还包括在电极和对电极中的一个上的涂层，该涂层包括用于酮的介体。 任选地，介体是铁氰化物。

    SYSTEMS AND METHODS FOR ELECTROCHEMICAL HEMATOCRIT DETERMINATION BY ALTERNATE CURRENT IMPEDANCE PHASE ANGLE DETERMINATIONS
    4.
    发明申请
    SYSTEMS AND METHODS FOR ELECTROCHEMICAL HEMATOCRIT DETERMINATION BY ALTERNATE CURRENT IMPEDANCE PHASE ANGLE DETERMINATIONS 审中-公开
    通过替代电流阻抗相位角确定进行电化学测定的系统和方法

    公开(公告)号：US20160146750A1

    公开(公告)日：2016-05-26

    申请号：US14952360

    申请日：2015-11-25

    申请人： Polymer Technology Systems, Inc.

    发明人： Gary L. Hughes ,  Ryan D. Jesswein

    IPC分类号： G01N27/327

    CPC分类号： G01N27/3274 ,  G01N27/3273 ,  G01N33/49

    摘要： A system for determining a level of hematocrit includes a test strip configured to receive a sample; a meter configured to receive the test strip; and further including circuitry and a microprocessor, the circuitry and microprocessor configured to apply electrical energy to the test strip and the sample and determine an electrical property of the sample, either the impedance phase angle or the impedance magnitude of the test strip and the sample and, based on the electrical property, calculate the level of hematocrit in the sample.

    摘要翻译： 用于确定血细胞比容水平的系统包括被配置为接收样品的测试条; 配置为接收测试条的仪表; 并且还包括电路和微处理器，所述电路和微处理器被配置为向测试条和样品施加电能并确定样品的电特性，测试条和样品的阻抗相位角或阻抗幅度，以及 根据电气特性，计算出样本中血细胞比容的水平。

    SYSTEMS AND METHODS FOR ELECTROCHEMICAL POINT-OF-CARE DETECTION OF HEMOGLOBIN
    8.
    发明公开
    SYSTEMS AND METHODS FOR ELECTROCHEMICAL POINT-OF-CARE DETECTION OF HEMOGLOBIN 审中-公开

    公开(公告)号：US20230305026A1

    公开(公告)日：2023-09-28

    申请号：US18328942

    申请日：2023-06-05

    申请人： POLYMER TECHNOLOGY SYSTEMS, INC.

    发明人： Donnie Smith ,  Brittney L. Werner ,  Gary L. Hughes ,  Jie Chen

    IPC分类号： G01N33/72 ,  C12N9/50 ,  G01N27/327

    CPC分类号： G01N33/721 ,  C12N9/50 ,  G01N27/3272 ,  G01N33/723

    摘要： A method is disclosed comprising lysing the red blood cells of a whole blood sample, oxidizing the free hemoglobin in the lysed sample, and cleaving FVH from the hemoglobin A1C to form an electrochemical test solution. In one aspect, a first portion of the electrochemical test solution is reacted with fructosyl peptide oxidase and a reduced ruthenium mediator to form a first reaction product. A first electrical property of the first reaction product is measured, the measurement being indicative of hemoglobin A1C in the blood sample. In another aspect, a second portion of the electrochemical test solution is reacted with ferrocyanide to form a second reaction product. A second electrical property of the second reaction product is measured, the measurement being indicative of total hemoglobin in the blood sample. Hemoglobin A1C, total hemoglobin, and % HbA1C are determined based on the first and second electrical properties. Also provided are systems and components useful in performing the disclosed methods.