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    PHYTOCHEMICAL COMPOSITIONS INCLUDING SESAMIN FOR ANTI-INFLAMMATORY, ANTI-CYTOKINE STORM, AND OTHER USES
    3.
    发明申请
    PHYTOCHEMICAL COMPOSITIONS INCLUDING SESAMIN FOR ANTI-INFLAMMATORY, ANTI-CYTOKINE STORM, AND OTHER USES 审中-公开
    包括用于抗炎，抗细菌因子和其他用途的SESAMIN的生物化学组合物

    公开(公告)号：US20120178712A1

    公开(公告)日：2012-07-12

    申请号：US13496189

    申请日：2009-09-14

    申请人： Prachya Kongtawelert

    发明人： Prachya Kongtawelert

    IPC分类号： A61K31/343 ,  A61P19/08 ,  A61K31/7008 ,  A61P3/06 ,  A61P31/16 ,  A61P29/00

    CPC分类号： A61K31/36 ,  A23L33/105 ,  A23V2002/00 ,  A61K45/06 ,  A23V2250/21 ,  A23V2200/324 ,  A23V2200/316

    摘要： A composition (e.g., phytochemical composition) including sesamin, the composition exhibiting anti-inflammatory, anti-cytokine storm, connective tissue preservation, anti-viral, and/or other properties in biological tissue. The phytochemical composition therapeutically affects a pro-inflammatory cytokine condition, for instance facilitating or effectuating decrease in a quantity of a pro-inflammatory cytokine, for example, interleukin-1 and tumor necrosis-alpha. The phytochemical composition facilitates or effectuates an increase in quantity of an anti-inflammatory cytokines. The phytochemical composition can additionally facilitate a connective tissue extracellular matrix (ECM) preservation effect. The phytochemical composition can also inhibit an action of a viral neuraminidase, for example, the influenza A virus neuraminidase. Uses of sesamin for the manufacture of phytochemical compositions having predetermined concentrations of sesamin include one or more of facilitating a decrease in quantity of pro-inflammatory cytokines, an increase in anti-inflammatory cytokines, a connective tissue anti-degenerative effect, and/or an inhibition of viral neuraminidase within the living organism. Manufacturing processes for the phytochemical compositions are also described.

    摘要翻译： 包括芝麻素的组合物（例如，植物化学组合物），组合物在生物组织中表现出抗炎，抗细胞因子风暴，结缔组织保存，抗病毒和/或其他性质。 植物化学组成物治疗性地影响促炎细胞因子条件，例如促进或实现促炎细胞因子（例如白细胞介素-1和肿瘤坏死-α）的量的减少。 植物化学成分促进或实现抗炎细胞因子的量的增加。 植物化学成分可另外促进结缔组织细胞外基质（ECM）的保存效果。 植物化学成分也可以抑制病毒性神经氨酸酶，例如甲型流感病毒神经氨酸酶的作用。 芝麻素用于制造具有预定浓度的芝麻素的植物化学组合物的用途包括促进促炎细胞因子量减少，抗炎细胞因子增加，结缔组织抗退行性作用和/或 抑制活体内的病毒神经氨酸酶。 还描述了植物化学组合物的制备方法。

    PHYTOCHEMICAL COMPOSITIONS INCLUDING XANTHONES FOR ANTI-INFLAMMATORY, ANTI-CYTOKINE STORM, AND OTHER USES
    4.
    发明申请
    PHYTOCHEMICAL COMPOSITIONS INCLUDING XANTHONES FOR ANTI-INFLAMMATORY, ANTI-CYTOKINE STORM, AND OTHER USES 审中-公开
    生物化学组合物，包括用于抗炎，抗细菌因子和其他用途的XANTHONES

    公开(公告)号：US20120172329A1

    公开(公告)日：2012-07-05

    申请号：US13496191

    申请日：2009-09-14

    申请人： Prachya Kongtawelert

    发明人： Prachya Kongtawelert

    IPC分类号： A61K31/352 ,  A61K31/7008 ,  A61P31/16 ,  A61P29/00 ,  A61P31/12 ,  A61K31/616 ,  A61K31/737

    CPC分类号： A61K31/352 ,  A23L33/105 ,  A61K2300/00

    摘要： A composition (e.g., a phytochemical composition) including a predetermined concentration of xanthones, and in certain embodiments predetermined concentrations of both xanthones and sesamin. The composition facilitates at least one of decreasing pro-inflammatory cytokines, increasing anti-inflammatory cytokines, enhancing a connective tissue anti- degeneration effect, and inhibiting viral neuraminidase (e.g. neuraminidase of an influenza A virus). The composition can further decrease at least one of gene expression and release of pro-inflammatory cytokines. The phytochemical composition can increase at least one of gene expression and release of anti-inflammatory cytokines. The phytochemical composition provides at least one of an anti-inflammatory, an anti-viral (e.g., anti-influenza), and a connective tissue anti-degradation effect in a living organism. A use of xanthones for manufacturing phytochemical compositions that include predetermined concentrations of xanthones is also provided. A use of xanthones in combination with sesamin for manufacturing phytochemical compositions that include predetermined concentrations of both xanthones and sesamin is additionally provided.

    摘要翻译： 包括预定浓度的呫吨酮的组合物（例如，植物化学组合物），在某些实施方案中，预定浓度的呫吨酮和芝麻素。 组合物促进减少促炎细胞因子，增加抗炎细胞因子，增强结缔组织抗变性作用和抑制病毒神经氨酸酶（例如甲型流感病毒的神经氨酸酶）中的至少一种。 组合物可以进一步降低基因表达和促炎细胞因子释放中的至少一种。 植物化学成分可以增加抗炎细胞因子的基因表达和释放中的至少一种。 植物化学组合物在活体中提供抗炎，抗病毒（例如抗流行性感冒）和结缔组织抗降解作用中的至少一种。 还提供了使用呫吨酮制备包含预定浓度的呫吨酮的植物化学组合物。 另外提供了将呫吨酮与芝麻素组合用于制备包括预定浓度的呫吨酮和芝麻素的植物化学成分的用途。