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    Purine Derivatives as adenosine A1 receptor agonists and methods of use thereof
    3.
    发明授权
    Purine Derivatives as adenosine A1 receptor agonists and methods of use thereof 有权
    嘌呤衍生物作为腺苷A1受体激动剂及其使用方法

    公开(公告)号：US07423144B2

    公开(公告)日：2008-09-09

    申请号：US11137632

    申请日：2005-05-25

    申请人： Prakash Jagtap ,  Csaba Szabo ,  Andrew L. Salzman

    发明人： Prakash Jagtap ,  Csaba Szabo ,  Andrew L. Salzman

    IPC分类号： A61K31/7056 ,  A61K31/7076 ,  A61K31/708 ,  C07H16/167 ,  C07H16/173

    CPC分类号： C07H19/167 ,  C07D473/34 ,  C07H19/12

    摘要： The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.

    摘要翻译： 本发明涉及嘌呤衍生物; 包含有效量的嘌呤衍生物的组合物; 以及降低动物代谢率的方法，保护动物的心脏免受心脏停搏期间的心肌损伤; 或用于治疗或预防心血管疾病，神经障碍，缺血状况，再灌注损伤，肥胖症，消耗性疾病或糖尿病，包括向有需要的动物施用有效量的嘌呤衍生物。

    Purine derivatives as adenosine A1 receptor agonists and methods of use thereof
    4.
    发明授权
    Purine derivatives as adenosine A1 receptor agonists and methods of use thereof 有权
    嘌呤衍生物作为腺苷A1受体激动剂及其使用方法

    公开(公告)号：US08183224B2

    公开(公告)日：2012-05-22

    申请号：US12221539

    申请日：2008-08-04

    申请人： Prakash Jagtap ,  Csaba Szabo ,  Andrew L. Salzman

    发明人： Prakash Jagtap ,  Csaba Szabo ,  Andrew L. Salzman

    IPC分类号： A61K31/7076 ,  C07H19/167

    CPC分类号： C07H19/167 ,  C07D473/34 ,  C07H19/12

    摘要： The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.

    摘要翻译： 本发明涉及嘌呤衍生物; 包含有效量的嘌呤衍生物的组合物; 以及降低动物代谢率的方法，保护动物的心脏免受心脏停搏期间的心肌损伤; 或用于治疗或预防心血管疾病，神经障碍，缺血状况，再灌注损伤，肥胖症，消耗性疾病或糖尿病，包括向有需要的动物施用有效量的嘌呤衍生物。

    Purine derivatives and methods of use thereof
    5.
    发明授权
    Purine derivatives and methods of use thereof 失效
    嘌呤衍生物及其使用方法

    公开(公告)号：US08133880B2

    公开(公告)日：2012-03-13

    申请号：US12945411

    申请日：2010-11-12

    申请人： Prakash Jagtap ,  Andrew L. Salzman ,  Csaba Szabo

    发明人： Prakash Jagtap ,  Andrew L. Salzman ,  Csaba Szabo

    IPC分类号： A61K31/70 ,  C07H19/167

    CPC分类号： C07H19/167 ,  C07H19/16

    摘要： The invention relates to Purine Derivatives having the formula; The invention also relates to pharmaceutical compositions comprising an effective amount of the Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurological disorder, a skin disorder, a radiation-induced injury, a wound, or an inflammatory disease comprising administering an effective amount of the Purine Derivative to a subject in need thereof.

    摘要翻译： 本发明涉及具有下式的嘌呤衍生物： 本发明还涉及包含有效量的嘌呤衍生物的药物组合物; 以及用于治疗或预防缺血状况，再灌注损伤，细胞增殖性疾病，心血管疾病，神经障碍，皮肤病症，辐射诱发的损伤，伤口或炎性疾病的方法，包括施用有效量的 嘌呤衍生物对有需要的受试者。

    Purine Derivatives and methods of use thereof
    6.
    发明授权
    Purine Derivatives and methods of use thereof 有权
    嘌呤衍生物及其使用方法

    公开(公告)号：US07863253B2

    公开(公告)日：2011-01-04

    申请号：US11230089

    申请日：2005-09-19

    申请人： Prakash Jagtap ,  Andrew L. Salzman ,  Csaba Szabo

    发明人： Prakash Jagtap ,  Andrew L. Salzman ,  Csaba Szabo

    IPC分类号： A61K31/70 ,  C07H19/167

    CPC分类号： C07H19/167 ,  C07H19/16

    摘要： The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurological disorder, a skin disorder, a radiation-induced injury, a wound, or an inflammatory disease comprising administering an effective amount of a Purine Derivative to a subject in need thereof. The Purine Derivatives include compounds of the following formula: or a pharmaceutically acceptable salt thereof, wherein A is —C(O)NHR3; B and C are —OH; D is

    摘要翻译： 本发明涉及嘌呤衍生物; 包含有效量的嘌呤衍生物的组合物; 以及用于治疗或预防缺血状况，再灌注损伤，细胞增殖性疾病，心血管疾病，神经障碍，皮肤病症，辐射诱发的损伤，伤口或炎性疾病的方法，包括施用有效量的 嘌呤衍生物对有需要的受试者。 嘌呤衍生物包括下式的化合物或其药学上可接受的盐，其中A是-C（O）NHR 3; B和C是-OH; D是

    Purine derivatives as adenosine A1 receptor agonists and methods of use thereof
    8.
    发明申请
    Purine derivatives as adenosine A1 receptor agonists and methods of use thereof 有权
    嘌呤衍生物作为腺苷A1受体激动剂及其使用方法

    公开(公告)号：US20090062314A1

    公开(公告)日：2009-03-05

    申请号：US12221539

    申请日：2008-08-04

    申请人： Prakash Jagtap ,  Csaba Szabo ,  Andrew L. Salzman

    发明人： Prakash Jagtap ,  Csaba Szabo ,  Andrew L. Salzman

    IPC分类号： A61K31/52 ,  A61P31/00

    CPC分类号： C07H19/167 ,  C07D473/34 ,  C07H19/12

    摘要： The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.

    摘要翻译： 本发明涉及嘌呤衍生物; 包含有效量的嘌呤衍生物的组合物; 以及降低动物代谢率的方法，保护动物的心脏免受心脏停搏期间的心肌损伤; 或用于治疗或预防心血管疾病，神经障碍，缺血状况，再灌注损伤，肥胖症，消耗性疾病或糖尿病，包括向有需要的动物施用有效量的嘌呤衍生物。