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109 条记录 (耗时 0.031 秒)

    Purine derivatives as adenosine A1 receptor agonists and methods of use thereof
    6.
    发明授权
    Purine derivatives as adenosine A1 receptor agonists and methods of use thereof 有权
    嘌呤衍生物作为腺苷A1受体激动剂及其使用方法

    公开(公告)号：US08183224B2

    公开(公告)日：2012-05-22

    申请号：US12221539

    申请日：2008-08-04

    申请人： Prakash Jagtap ,  Csaba Szabo ,  Andrew L. Salzman

    发明人： Prakash Jagtap ,  Csaba Szabo ,  Andrew L. Salzman

    IPC分类号： A61K31/7076 ,  C07H19/167

    CPC分类号： C07H19/167 ,  C07D473/34 ,  C07H19/12

    摘要： The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.

    摘要翻译： 本发明涉及嘌呤衍生物; 包含有效量的嘌呤衍生物的组合物; 以及降低动物代谢率的方法，保护动物的心脏免受心脏停搏期间的心肌损伤; 或用于治疗或预防心血管疾病，神经障碍，缺血状况，再灌注损伤，肥胖症，消耗性疾病或糖尿病，包括向有需要的动物施用有效量的嘌呤衍生物。

    Purine Derivatives as adenosine A1 receptor agonists and methods of use thereof
    7.
    发明授权
    Purine Derivatives as adenosine A1 receptor agonists and methods of use thereof 有权
    嘌呤衍生物作为腺苷A1受体激动剂及其使用方法

    公开(公告)号：US07423144B2

    公开(公告)日：2008-09-09

    申请号：US11137632

    申请日：2005-05-25

    申请人： Prakash Jagtap ,  Csaba Szabo ,  Andrew L. Salzman

    发明人： Prakash Jagtap ,  Csaba Szabo ,  Andrew L. Salzman

    IPC分类号： A61K31/7056 ,  A61K31/7076 ,  A61K31/708 ,  C07H16/167 ,  C07H16/173

    CPC分类号： C07H19/167 ,  C07D473/34 ,  C07H19/12

    摘要： The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.

    摘要翻译： 本发明涉及嘌呤衍生物; 包含有效量的嘌呤衍生物的组合物; 以及降低动物代谢率的方法，保护动物的心脏免受心脏停搏期间的心肌损伤; 或用于治疗或预防心血管疾病，神经障碍，缺血状况，再灌注损伤，肥胖症，消耗性疾病或糖尿病，包括向有需要的动物施用有效量的嘌呤衍生物。

    Purine derivatives and methods of use thereof
    8.
    发明授权
    Purine derivatives and methods of use thereof 失效
    嘌呤衍生物及其使用方法

    公开(公告)号：US08133880B2

    公开(公告)日：2012-03-13

    申请号：US12945411

    申请日：2010-11-12

    申请人： Prakash Jagtap ,  Andrew L. Salzman ,  Csaba Szabo

    发明人： Prakash Jagtap ,  Andrew L. Salzman ,  Csaba Szabo

    IPC分类号： A61K31/70 ,  C07H19/167

    CPC分类号： C07H19/167 ,  C07H19/16

    摘要： The invention relates to Purine Derivatives having the formula; The invention also relates to pharmaceutical compositions comprising an effective amount of the Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurological disorder, a skin disorder, a radiation-induced injury, a wound, or an inflammatory disease comprising administering an effective amount of the Purine Derivative to a subject in need thereof.

    摘要翻译： 本发明涉及具有下式的嘌呤衍生物： 本发明还涉及包含有效量的嘌呤衍生物的药物组合物; 以及用于治疗或预防缺血状况，再灌注损伤，细胞增殖性疾病，心血管疾病，神经障碍，皮肤病症，辐射诱发的损伤，伤口或炎性疾病的方法，包括施用有效量的 嘌呤衍生物对有需要的受试者。

    Purine Derivatives and methods of use thereof
    9.
    发明授权
    Purine Derivatives and methods of use thereof 有权
    嘌呤衍生物及其使用方法

    公开(公告)号：US07863253B2

    公开(公告)日：2011-01-04

    申请号：US11230089

    申请日：2005-09-19

    申请人： Prakash Jagtap ,  Andrew L. Salzman ,  Csaba Szabo

    发明人： Prakash Jagtap ,  Andrew L. Salzman ,  Csaba Szabo

    IPC分类号： A61K31/70 ,  C07H19/167

    CPC分类号： C07H19/167 ,  C07H19/16

    摘要： The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurological disorder, a skin disorder, a radiation-induced injury, a wound, or an inflammatory disease comprising administering an effective amount of a Purine Derivative to a subject in need thereof. The Purine Derivatives include compounds of the following formula: or a pharmaceutically acceptable salt thereof, wherein A is —C(O)NHR3; B and C are —OH; D is

    摘要翻译： 本发明涉及嘌呤衍生物; 包含有效量的嘌呤衍生物的组合物; 以及用于治疗或预防缺血状况，再灌注损伤，细胞增殖性疾病，心血管疾病，神经障碍，皮肤病症，辐射诱发的损伤，伤口或炎性疾病的方法，包括施用有效量的 嘌呤衍生物对有需要的受试者。 嘌呤衍生物包括下式的化合物或其药学上可接受的盐，其中A是-C（O）NHR 3; B和C是-OH; D是