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    Tetracyclic lactam derivatives and uses thereof
    7.
    发明申请
    Tetracyclic lactam derivatives and uses thereof 审中-公开
    四环内酰胺衍生物及其用途

    公开(公告)号：US20050261288A1

    公开(公告)日：2005-11-24

    申请号：US11067324

    申请日：2005-02-25

    申请人： Prakash Jagtap ,  William Williams ,  Csaba Szabo

    发明人： Prakash Jagtap ,  William Williams ,  Csaba Szabo

    IPC分类号： A61K31/473 ,  A61K31/4745 ,  A61K31/5377 ,  A61P29/00 ,  A61P35/00 ,  C07D221/18 ,  C07D403/12 ,  C07D471/02 ,  C07D471/04

    CPC分类号： C07D221/18 ,  C07D403/12 ,  C07D471/04

    摘要： The present invention relates to Tetracyclic Lactam Derivatives, compositions comprising an effective amount of a Tetracyclic Lactam Derivative and methods for treating or preventing an inflammatory disease, a reperfusion injury, an ischemic condition, renal failure, diabetes, a diabetic complication, a vascular disease, reoxygenation injury resulting from organ transplantation, Parkinson's disease, or cancer, comprising administering to an animal in need thereof an effective amount of a Tetracyclic Lactam Derivative.

    摘要翻译： 本发明涉及四环内酰胺衍生物，包含有效量的四环内酰胺衍生物的组合物和治疗或预防炎性疾病，再灌注损伤，缺血状况，肾衰竭，糖尿病，糖尿病并发症，血管疾病， 由器官移植，帕金森病或癌症引起的再氧化损伤，包括向有需要的动物施用有效量的四环内酰胺衍生物。

    Pyridyl-substituted porphyrin compounds and methods of use thereof
    9.
    发明申请
    Pyridyl-substituted porphyrin compounds and methods of use thereof 审中-公开

    公开(公告)号：US20080009473A1

    公开(公告)日：2008-01-10

    申请号：US11880068

    申请日：2007-07-19

    申请人： William Williams ,  Garry Southan ,  Csaba Szabo

    发明人： William Williams ,  Garry Southan ,  Csaba Szabo

    IPC分类号： A61K31/555 ,  A61P39/06

    CPC分类号： C07D487/22 ,  C07F11/005 ,  C07F13/005 ,  C07F15/025

    摘要： The present invention relates to Pyridyl-Substituted Porphyrin Compounds, compositions comprising an effective amount of a Pyridyl-Substituted Porphyrin Compound and methods for treating or preventing injury due to exposure to a reactive species, erectile dysfunction due to surgery, lung disease, hyperoxia, neurodegenerative disease, liver disease, myocardial damage during cardioplegia, an inflammatory condition, a reperfusion injury, an ischemic condition, a cardiovascular disease, diabetes, a diabetic complication, cancer, a side effect of cancer chemotherapy, or a radiation-induced injury, or to prolong the half-life of an oxidation-prone compound, comprising administering to a subject in need thereof an effective amount of a Pyridyl-Substituted Porphyrin Compound.

    Pyridyl-substituted porphyrin compounds and methods of use thereof
    10.
    发明申请
    Pyridyl-substituted porphyrin compounds and methods of use thereof 失效
    吡啶基取代的卟啉化合物及其使用方法

    公开(公告)号：US20060003982A1

    公开(公告)日：2006-01-05

    申请号：US11090447

    申请日：2005-03-25

    申请人： William Williams ,  Garry Southan ,  Csaba Szabo

    发明人： William Williams ,  Garry Southan ,  Csaba Szabo

    IPC分类号： A61K31/555 ,  C07F15/02

    CPC分类号： C07D487/22 ,  C07F11/005 ,  C07F13/005 ,  C07F15/025

    摘要： The present invention relates to Pyridyl-Substituted Porphyrin Compounds, compositions comprising an effective amount of a Pyridyl-Substituted Porphyrin Compound and methods for treating or preventing injury due to exposure to a reactive species, erectile dysfunction due to surgery, lung disease, hyperoxia, neurodegenerative disease, liver disease, myocardial damage during cardioplegia, an inflammatory condition, a reperfusion injury, an ischemic condition, a cardiovascular disease, diabetes, a diabetic complication, cancer, a side effect of cancer chemotherapy, or a radiation-induced injury, or to prolong the half-life of an oxidation-prone compound, comprising administering to a subject in need thereof an effective amount of a Pyridyl-Substituted Porphyrin Compound.

    摘要翻译： 本发明涉及吡啶基取代的卟啉化合物，包含有效量的吡啶基取代的卟啉化合物的组合物和用于治疗或预防由于暴露于反应性物质引起的损伤，由于手术引起的勃起功能障碍，肺部疾病，高氧，神经变性 疾病，肝脏疾病，心脏停搏期间的心肌损伤，炎症状况，再灌注损伤，缺血状况，心血管疾病，糖尿病，糖尿病并发症，癌症，癌症化疗的副作用或辐射诱发的损伤，或 延长易氧化化合物的半衰期，包括向有需要的受试者施用有效量的吡啶基取代的卟啉化合物。