公开(公告)号：US20120115907A1

公开(公告)日：2012-05-10

申请号：US13265537

申请日：2010-04-22

申请人： Pravain Thombare ,  Jigar Desai ,  Mukul R. Jain

发明人： Pravain Thombare ,  Jigar Desai ,  Mukul R. Jain

IPC分类号： A61K31/4468 ,  C07D401/06 ,  A61K31/4545 ,  C07D405/06 ,  A61K31/453 ,  A61P9/12 ,  A61P9/04 ,  A61P13/12 ,  A61P9/00 ,  A61P9/10 ,  A61P7/00 ,  A61P25/00 ,  A61P27/06 ,  A61P27/02 ,  A61P15/10 ,  A61P5/40 ,  A61P11/00 ,  A61P17/00 ,  A61P25/22 ,  A61P25/28 ,  C07D211/58

CPC分类号： C07D211/60 ,  C07D405/12

摘要： The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

摘要翻译： 本发明涉及通式（1）的新型肾素抑制剂，涉及其合成的新中间体，其药学上可接受的盐和含有它们的药物组合物。 本发明还涉及制备通式（1）的化合物，其互变异构形式，其药学上可接受的盐，含有它们的药物组合物和参与其合成的新中间体的方法。

公开(公告)号：US20100280024A1

公开(公告)日：2010-11-04

申请号：US12682720

申请日：2008-10-13

申请人： Jigar Desai ,  Pravin S. Thombare ,  Mukul R. Jain ,  Pankaj Ramanbhai Patel

发明人： Jigar Desai ,  Pravin S. Thombare ,  Mukul R. Jain ,  Pankaj Ramanbhai Patel

IPC分类号： A61K31/536 ,  C07D215/14 ,  A61K31/47 ,  C07D217/00 ,  C07D265/36 ,  C07D211/32 ,  A61K31/445 ,  C07D403/02 ,  A61K31/506 ,  C07D241/04 ,  A61K31/495 ,  C07D207/00 ,  A61K31/40 ,  C07D295/00 ,  A61K31/5375 ,  A61K31/4709 ,  C07D401/00 ,  A61K31/4545 ,  A61P9/12

CPC分类号： C07D215/08 ,  C07D207/14 ,  C07D207/16 ,  C07D209/08 ,  C07D211/16 ,  C07D211/22 ,  C07D213/64 ,  C07D215/12 ,  C07D215/14 ,  C07D215/18 ,  C07D215/20 ,  C07D215/26 ,  C07D217/06 ,  C07D265/36 ,  C07D295/185 ,  C07D401/06 ,  C07D403/04

摘要： The present invention relates to renin inhibitors of formula (I), their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (I), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

摘要翻译： 本发明涉及式（I）的肾素抑制剂，其药学上可接受的盐和含有它们的药物组合物。 本发明还涉及制备通式（I）的化合物，其互变异构形式，其药学上可接受的盐，含有它们的药物组合物和涉及其合成的新中间体的方法。

公开(公告)号：US20230220384A1

公开(公告)日：2023-07-13

申请号：US17766677

申请日：2020-10-06

申请人： Prashant MONIAN ,  Chikdu Shakti SHIVAILA ,  Subramanian MARAPPAN ,  Chandra VARGEESE ,  Pachamuthu KANDASAMY ,  Genliang LU ,  Hui YU ,  David Charles Donnell BUTLER ,  Luciano Henrique APPONI ,  Mamoru SHIMIZU ,  Stephany Michelle STANDLEY ,  David John BOULAY ,  Andrew Guzior HOSS ,  Jigar DESAI ,  Jack David GODFREY ,  Hailin YANG ,  Naoki IWAMOTO ,  WAVE LIFE SCIENCES LTD.

发明人： Prashant Monian ,  Chikdu Shakti Shivalila ,  Subramanian Marappan ,  Chandra Vargeese ,  Pachamuthu Kandasamy ,  Genliang Lu ,  Hui Yu ,  David Charles Donnell Butler ,  Luciano Henrique Apponi ,  Mamoru Shimizu ,  Stephany Michelle Standley ,  David John Boulay ,  Andrew Guzior Hoss ,  Jigar Desai ,  Jack David Godfrey ,  Hailin Yang ,  Naoki Iwamoto

IPC分类号： C12N15/113

CPC分类号： C12N15/113 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2310/314 ,  C12N2310/322 ,  C12N2310/321 ,  C12N2310/315

摘要： Among other things, the present disclosure provides oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions are useful for adenosine modification. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine modification.

公开(公告)号：US20120226588A1

公开(公告)日：2012-09-06

申请号：US13341158

申请日：2011-12-30

申请人： Chris Wuhrer ,  Jerome Myers ,  Sarah Owen ,  Caryn L. Dixon ,  Sameer S. Bharwani ,  J. Scott Sanchez ,  Pranav Kariwala ,  Jigar Desai ,  Yinchuan Tan

发明人： Chris Wuhrer ,  Jerome Myers ,  Sarah Owen ,  Caryn L. Dixon ,  Sameer S. Bharwani ,  J. Scott Sanchez ,  Pranav Kariwala ,  Jigar Desai ,  Yinchuan Tan

IPC分类号： G06Q30/06

CPC分类号： G06Q30/06 ,  G06Q20/12 ,  G07F17/40

摘要： Systems and methods for electronic commerce using a dynamic checkout and/or group gifting are provided. The dynamic checkout process can be integrated with a social platform electronic commerce experience allowing a user to select a single gift, multiple gifts, and/or to create a basket of goods to send to one or multiple recipients. The dynamic checkout allows the user to select the desired recipient(s) before, after, or intermixed with selecting the offers and/or creating the basket of goods. These offers or products can be purchased by the user with a single payment which will be appropriately apportioned to the merchants based on the products purchased. Once the payment has been successfully processed, an electronic delivery or a physical delivery of the goods or products will occur.

摘要翻译： 提供了使用动态结帐和/或组送礼的电子商务的系统和方法。 动态结帐过程可以与社交平台电子商务体验相集成，允许用户选择单个礼物，多个礼物，和/或创建一篮子商品以发送给一个或多个收件人。 动态结帐允许用户在选择提供和/或创建商品篮之前，之后或混合时选择所需的收件人。 这些优惠或产品可以由用户购买一笔付款，这些付款将根据购买的产品适当地分配给商家。 一旦付款已经成功处理，将发生货物或产品的电子交货或实际交货。