公开(公告)号：US08835187B2

公开(公告)日：2014-09-16

申请号：US13960751

申请日：2013-08-06

Applicant: President and Fellows of Harvard College

Inventor： J. Christopher Love ,  Hidde L. Ploegh ,  Jehnna Ronan

IPC: G01N33/53 ,  B82Y30/00 ,  G01N33/543 ,  G01N33/68 ,  G01N33/50 ,  G01N33/577 ,  G01N21/64 ,  B01L3/00 ,  G01N33/531

CPC classification number: B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00675 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00734 ,  B01J2219/0074 ,  B01L3/50853 ,  B01L2200/025 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2300/12 ,  B82Y30/00 ,  G01N21/6452 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/531 ,  G01N33/543 ,  G01N33/54366 ,  G01N33/577 ,  G01N33/6854 ,  Y10S436/809

Abstract: Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.

公开(公告)号：US20220032257A1

公开(公告)日：2022-02-03

申请号：US17479515

申请日：2021-09-20

Applicant: President and Fellows of Harvard College

Inventor： J. Christopher Love ,  Hidde L. Ploegh ,  Jehnna Ronan

IPC: B01J19/00 ,  B01L3/00 ,  B82Y30/00 ,  G01N21/64 ,  G01N33/50 ,  G01N33/531 ,  G01N33/543 ,  G01N33/577 ,  G01N33/68

Abstract: Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.

公开(公告)号：US10137426B2

公开(公告)日：2018-11-27

申请号：US15267977

申请日：2016-09-16

Applicant: President and Fellows of Harvard College

Inventor： J. Christopher Love ,  Hidde L. Ploegh ,  Jehnna Ronan

IPC: G01N33/53 ,  B01J19/00 ,  G01N33/543 ,  B01L3/00 ,  G01N21/64 ,  B82Y30/00 ,  G01N33/50 ,  G01N33/68 ,  G01N33/577 ,  G01N33/531

Abstract: Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.

公开(公告)号：US20130338030A1

公开(公告)日：2013-12-19

申请号：US13960757

申请日：2013-08-06

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： J. Christopher Love ,  Hidde L. Ploegh ,  Jehnna Ronan

IPC: G01N33/577

CPC classification number: B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00675 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00734 ,  B01J2219/0074 ,  B01L3/50853 ,  B01L2200/025 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2300/12 ,  B82Y30/00 ,  G01N21/6452 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/531 ,  G01N33/543 ,  G01N33/54366 ,  G01N33/577 ,  G01N33/6854 ,  Y10S436/809

Abstract: Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.

Abstract translation: 提供了筛选测定和进行这种测定的方法。 在某些实施例中，可以设计测定和方法以确定两种或更多种类是否可以彼此结合。 在一些实例中，测定和方法可用于确定已知抗原是否与未知单克隆抗体结合。

公开(公告)号：US20160045885A1

公开(公告)日：2016-02-18

申请号：US14928607

申请日：2015-10-30

Applicant: President and Fellows of Harvard College

Inventor： J. Christopher Love ,  Hidde L. Ploegh ,  Jehnna Ronan

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00675 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00734 ,  B01J2219/0074 ,  B01L3/50853 ,  B01L2200/025 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2300/12 ,  B82Y30/00 ,  G01N21/6452 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/531 ,  G01N33/543 ,  G01N33/54366 ,  G01N33/577 ,  G01N33/6854 ,  Y10S436/809

Abstract: Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.

公开(公告)号：US20190046944A1

公开(公告)日：2019-02-14

申请号：US16170323

申请日：2018-10-25

Applicant: President and Fellows of Harvard College

Inventor： J. Christopher Love ,  Hidde L. Ploegh ,  Jehnna Ronan

IPC: B01J19/00 ,  B82Y30/00 ,  G01N33/50 ,  G01N33/543 ,  G01N33/68 ,  G01N33/531 ,  G01N33/577 ,  G01N21/64 ,  B01L3/00

Abstract: Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.

公开(公告)号：US20170001166A1

公开(公告)日：2017-01-05

申请号：US15267977

申请日：2016-09-16

Applicant: President and Fellows of Harvard College

Inventor： J. Christopher Love ,  Hidde L. Ploegh ,  Jehnna Ronan

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00675 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00734 ,  B01J2219/0074 ,  B01L3/50853 ,  B01L2200/025 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2300/12 ,  B82Y30/00 ,  G01N21/6452 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/531 ,  G01N33/543 ,  G01N33/54366 ,  G01N33/577 ,  G01N33/6854 ,  Y10S436/809

Abstract: Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.

Abstract translation: 提供了筛选测定和进行这种测定的方法。 在某些实施例中，可以设计测定和方法以确定两种或更多种类是否可以彼此结合。 在一些实例中，测定和方法可用于确定已知抗原是否与未知单克隆抗体结合。

公开(公告)号：US08772049B2

公开(公告)日：2014-07-08

申请号：US13960757

申请日：2013-08-06

Applicant: President and Fellows of Harvard College

Inventor： J. Christopher Love ,  Hidde L. Ploegh ,  Jehnna Ronan

IPC: G01N33/53

CPC classification number: B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00675 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00734 ,  B01J2219/0074 ,  B01L3/50853 ,  B01L2200/025 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2300/12 ,  B82Y30/00 ,  G01N21/6452 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/531 ,  G01N33/543 ,  G01N33/54366 ,  G01N33/577 ,  G01N33/6854 ,  Y10S436/809

Abstract: Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.

Abstract translation: 提供了筛选测定和进行这种测定的方法。 在某些实施例中，可以设计测定和方法以确定两种或更多种类是否可以彼此结合。 在一些实例中，测定和方法可用于确定已知抗原是否与未知单克隆抗体结合。

公开(公告)号：US20130338047A1

公开(公告)日：2013-12-19

申请号：US13960754

申请日：2013-08-06

Applicant: President and Fellows of Harvard College

Inventor： J. Christopher Love ,  Hidde L. Ploegh ,  Jehnna Ronan

IPC: G01N33/577

CPC classification number: B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00675 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00734 ,  B01J2219/0074 ,  B01L3/50853 ,  B01L2200/025 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2300/12 ,  B82Y30/00 ,  G01N21/6452 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/531 ,  G01N33/543 ,  G01N33/54366 ,  G01N33/577 ,  G01N33/6854 ,  Y10S436/809

Abstract: Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.

公开(公告)号：US11154833B2

公开(公告)日：2021-10-26

申请号：US16170323

申请日：2018-10-25

Applicant: President and Fellows of Harvard College

Inventor： J. Christopher Love ,  Hidde L. Ploegh ,  Jehnna Ronan

IPC: G01N33/543 ,  B01J19/00 ,  B01L3/00 ,  G01N21/64 ,  B82Y30/00 ,  G01N33/50 ,  G01N33/68 ,  G01N33/577 ,  G01N33/531

Abstract: Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.