公开(公告)号：US20220364030A1

公开(公告)日：2022-11-17

申请号：US17876283

申请日：2022-07-28

Applicant: President and Fellows of Harvard College

Inventor： Christopher David Hinojosa ,  Josiah Sliz ,  Daniel Levner ,  Guy Thompson ,  Hubert Geisler ,  Jose Fernandez-Alcon ,  Donald E. Ingber

IPC: C12M3/06 ,  B01L3/00 ,  B82Y15/00 ,  C12M1/34 ,  G01N33/50 ,  C12M3/00 ,  C12M1/26

Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

公开(公告)号：US11434458B2

公开(公告)日：2022-09-06

申请号：US15403942

申请日：2017-01-11

Applicant: President and Fellows of Harvard College

Inventor： Christopher David Hinojosa ,  Josiah Sliz ,  Daniel Levner ,  Guy Thompson ,  Hubert Geisler ,  Jose Fernandez-Alcon ,  Donald E. Ingber

IPC: C12M3/06 ,  B01L3/00 ,  B82Y15/00 ,  C12M1/34 ,  G01N33/50 ,  C12M3/00 ,  C12M1/26

Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

公开(公告)号：US11034926B2

公开(公告)日：2021-06-15

申请号：US15403949

申请日：2017-01-11

Applicant: President and Fellows of Harvard College

Inventor： Christopher David Hinojosa ,  Josiah Sliz ,  Daniel Levner ,  Guy Thompson ,  Hubert Geisler ,  Jose Fernandez-Alcon ,  Donald E. Ingber

IPC: C12M3/06 ,  B01L3/00 ,  B82Y15/00 ,  C12M1/34 ,  G01N33/50 ,  C12M3/00 ,  C12M1/26

Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

公开(公告)号：US20170121659A1

公开(公告)日：2017-05-04

申请号：US15403944

申请日：2017-01-11

Applicant: President and Fellows of Harvard College

Inventor： Christopher David Hinojosa ,  Josiah Sliz ,  Daniel Levner ,  Guy Thompson ,  Hubert Geisler ,  Jose Fernandez-Alcon ,  Donald E. Ingber

IPC: C12M3/06 ,  C12M1/34 ,  C12M3/00 ,  B01L3/00

CPC classification number: C12M23/16 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2300/044 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/084 ,  B82Y15/00 ,  C12M21/08 ,  C12M33/12 ,  C12M41/00 ,  C12M41/40 ,  C12M41/46 ,  G01N33/5005

Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

公开(公告)号：US10407655B2

公开(公告)日：2019-09-10

申请号：US15403944

申请日：2017-01-11

Applicant: President and Fellows of Harvard College

Inventor： Christopher David Hinojosa ,  Josiah Sliz ,  Daniel Levner ,  Guy Thompson ,  Hubert Geisler ,  Jose Fernandez-Alcon ,  Donald E. Ingber

IPC: B01L3/00 ,  C12M1/34 ,  C12M1/26 ,  C12M3/00 ,  C12M3/06 ,  B82Y15/00 ,  G01N33/50

Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

公开(公告)号：US20170121663A1

公开(公告)日：2017-05-04

申请号：US15403949

申请日：2017-01-11

Applicant: President and Fellows of Harvard College

Inventor： Christopher David Hinojosa ,  Josiah Sliz ,  Daniel Levner ,  Guy Thompson ,  Hubert Geisler ,  Jose Fernandez-Alcon ,  Donald E. Ingber

IPC: C12M1/34 ,  C12M1/26 ,  B01L3/00 ,  C12M3/06

CPC classification number: C12M23/16 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2300/044 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/084 ,  B82Y15/00 ,  C12M21/08 ,  C12M33/12 ,  C12M41/00 ,  C12M41/40 ,  C12M41/46 ,  G01N33/5005

Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

公开(公告)号：US20170121658A1

公开(公告)日：2017-05-04

申请号：US15403942

申请日：2017-01-11

Applicant: President and Fellows of Harvard College

Inventor： Christopher David Hinojosa ,  Josiah Sliz ,  Daniel Levner ,  Guy Thompson ,  Hubert Geisler ,  Jose Fernandez-Alcon ,  Donald E. Ingber

IPC: C12M3/06 ,  C12M1/34 ,  C12M3/00 ,  B01L3/00

CPC classification number: C12M23/16 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2300/044 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/084 ,  B82Y15/00 ,  C12M21/08 ,  C12M33/12 ,  C12M41/00 ,  C12M41/40 ,  C12M41/46 ,  G01N33/5005

Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.